期刊
CHEMPHYSCHEM
卷 14, 期 13, 页码 3059-3070出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cphc.201300339
关键词
energy landscapes; fast multidimensional nmr spectroscopy; protein folding; real-time nmr spectroscopy; RNA switches
资金
- French ANR [ANR-08-BLAN-0210-EXSTASY, ANR-11-IS07-RNAfolding]
- European Commission [261863]
- Agence Nationale de la Recherche (ANR) [ANR-08-BLAN-0210] Funding Source: Agence Nationale de la Recherche (ANR)
The characterization of both the structure and the conformational dynamics of biological macromolecules, namely proteins and nucleic acids, is required for understanding the molecular mechanisms underlying physiological function and disease. Molecular dynamics involves the transient departure from the ground-state structures to populate short-lived excited state conformations that can play important functional roles. Real-time multi-dimensional NMR spectroscopy represents a unique tool for investigating dynamic molecular processes occurring on time scales of seconds or longer, providing atomic-resolution information about short-lived states. In this minireview, we discuss recent progress made in the field of fast real-time multidimensional NMR. The potential of these new methods is illustrated for several biomolecular systems that have recently been studied by fast real-time multidimensional NMR.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据