Review
Chemistry, Multidisciplinary
Nikita V. Chukanov, Roman V. Shchepin, Sameer M. Joshi, Mohammad S. H. Kabir, Oleg G. Salnikov, Alexandra Svyatova, Igor V. Koptyug, Juri G. Gelovani, Eduard Y. Chekmenev
Summary: NMR hyperpolarization techniques greatly increase nuclear spin polarization, leading to significant sensitivity gains for applications in high-resolution NMR spectroscopy and real-time metabolic imaging. Various hyperpolarization techniques exist, with a focus on targeting C-13 and N-15 sites in biocompatible agents. Long T-1 values of these sites allow hyperpolarized states to be retained for extended periods, with SABRE being a versatile low-cost technique for hyperpolarization of N-15 nuclei.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Gregory J. Rees, Dominic Spencer Jolly, Ziyang Ning, T. James Marrow, Galina E. Pavlovskaya, Peter G. Bruce
Summary: This study utilized Na-23 MRI to directly observe the microstructural growth of sodium in an all-solid-state cell, revealing a porous dendritic morphology which was confirmed through various methods. The significantly larger T-2 contrast for dendritic growth compared to bulk metal electrode is attributed to increased sodium ion mobility within the dendrite. Na-23 T-2 contrast MRI of metallic sodium provides a clear and routine method for observing and isolating microstructural growth, complementing current techniques for analyzing dendritic growth in all-solid-state cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Multidisciplinary Sciences
K. S. Cujia, K. Herb, J. Zopes, J. M. Abendroth, C. L. Degen
Summary: The study extends nuclear magnetic resonance imaging to large nuclear spin clusters by combining weak quantum measurements, phase encoding, and simulated annealing. This method allows for the simultaneous detection of three-dimensional positions from multiple nuclei, with spatial selectivity and successful imaging of clusters containing multiple nuclear spins at room temperature.
NATURE COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Alixander S. Khan, Rebecca L. Harvey, Jonathan R. Birchall, Robert K. Irwin, Panayiotis Nikolaou, Geoffry Schrank, Kiarash Emami, Andrew Dummer, Michael J. Barlow, Boyd M. Goodson, Eduard Y. Chekmenev
Summary: Hyperpolarization techniques can significantly increase nuclear magnetic resonance signals and have great potential in biomedical applications, especially in lung imaging. Hyperpolarized Xe-129 offers more functional information and faster imaging speed compared to CT and conventional MRI.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Multidisciplinary Sciences
Ajin Joy, M. Albert Thomas
Summary: Covariance transformation and Inner Product can significantly increase the resolution of 2D COSY spectrum without affecting the spectral width, leading to a reliable measure of unsaturation index for malignant breast cancer.
SCIENTIFIC REPORTS
(2023)
Review
Chemistry, Multidisciplinary
Dorothea Wisser, Martin Hartmann
Summary: NMR spectroscopy of xenon is a powerful method for probing pore sizes and structures in functional and catalytic materials, providing insights into hierarchical structures. This technique has both possibilities and limitations, as highlighted in recent works.
ADVANCED MATERIALS INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Lingshan Gong, Yingxiang Ye, Ying Liu, Yunbin Li, Zongbi Bao, Shengchang Xiang, Zhangjing Zhang, Banglin Chen
Summary: In this study, a novel ultramicroporous hydrogen-bonded organic framework (HOF-40) constructed from a cyano-based organic building unit was reported. The results showed that HOF-40 exhibited superior separation performance for xenon/krypton mixtures, and the pore confinement effect and abundant accessible binding sites played a synergistic role in this challenging gas separation.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Brijith Thomas, Daniel Jardon-Alvarez, Raanan Carmieli, Johan van Tol, Michal Leskes
Summary: In DNP-NMR experiments, the polarization of unpaired electrons is transferred to nuclei, increasing the sensitivity of NMR signal. While this method is efficient in crystalline inorganic oxides, it is less effective in oxide glasses. The difference in efficiency can be attributed to shorter relaxation times and dielectric properties in glasses. These findings provide guidance in identifying suitable materials for the DNP approach.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Organic
Trinadh Kaicharla, Bhavani Shankar Chinta, Thomas R. Hoye
Summary: This article provides examples that demonstrate the value of using properly designed and easily performed doping experiments to gain insights about the nature of analytes in a H-1 NMR sample. By conducting doping experiments on a complex mixture and a simple mixture, multiple compounds were successfully identified, highlighting the advantage of doping experiments over comparing spectra from separate samples containing the same analyte.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Nanoscience & Nanotechnology
Philip Saul, Leif Schroder, Andreas B. B. Schmidt, Jan-Bernd Hovener
Summary: Nanomaterials are crucial in the development and application of hyperpolarized materials for MRI. They can function as both directly imaged hyperpolarized materials, carriers for hyperpolarized gases, and catalysts for generating hyperpolarized substrates. This article provides an overview of recent developments in these three application possibilities, highlighting carbon-based materials for direct imaging. The importance of nanomaterials in MRI is discussed, including their biocompatibility and imaging experiments.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Editorial Material
Chemistry, Multidisciplinary
Geoffrey Bodenhausen
Summary: Richard Ernst's scientific legacy in magnetic resonance research is highlighted, spanning various areas such as chemical exchange, Overhauser effects, cross-correlated relaxation, quantum computing, and phase encoding in magnetic resonance imaging.
Review
Biochemistry & Molecular Biology
Uma Sharma, Naranamangalam R. Jagannathan
Summary: This article reviews the application of NMR, MRS, and MRI methods in understanding breast cancer biology, as well as in the diagnosis and therapeutic monitoring of breast cancer.
Article
Engineering, Environmental
Qiang Liu, Youjin Gong, Boyu Liu, Shunshun Xiong, Hui-Min Wen, Xiaolin Wang
Summary: In this study, an ultra-microporous alkyl Cu-based MOF-11 was developed for highly selective adsorption of xenon. The unique pore system of MOF-11 not only enables strong binding affinity with xenon, but also allows for dense packing of xenon molecules. MOF-11 demonstrates record-high xenon storage density, uptake, and selectivity, making it a promising candidate for xenon separation and capture.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biophysics
Andres T. Cavazos, Edward Ross Pennington, Sahil Dadoo, Kymberly M. Gowdy, Stephen R. Wassall, Saame Raza Shaikh
Summary: Long-chain polyunsaturated fatty acids are prone to oxidation and play a role in controlling inflammatory response. The mechanism of action by which oxidized PUFAs exert their functional effects remains unclear.
BIOPHYSICAL JOURNAL
(2023)
Article
Physics, Applied
E. D. Herbschleb, I. Ohki, K. Morita, Y. Yoshii, H. Kato, T. Makino, S. Yamasaki, N. Mizuochi
Summary: Exquisite sensitivities are a prominent advantage of quantum sensors. In this paper, a fitting-based algorithm with frequency-independent sensitivity is proposed to coherently measure low-frequency fields. The algorithm demonstrates a sensitivity of 9.4 nT Hz(-0.5) for frequencies below 0.6 kHz, showing its potential in various scenarios.
PHYSICAL REVIEW APPLIED
(2022)
Article
Engineering, Biomedical
Moritz K. Brockhaus, Stephan Hildebrand, Mario Diedrich, Marvin Lowes, Heiko De Ben, Thomas Schmitz-Rode, Ulrich Steinseifer, Sebastian Jansen
Summary: A downsized version of the ReinHeart total artificial heart was developed and tested for hemocompatibility. The hemolysis level increased by approximately 22% compared to the original size version, but it can still be considered acceptable.
Article
Engineering, Biomedical
Stephan Hildebrand, Sascha Gross-Hardt, Thomas Schmitz-Rode, Ulrich Steinseifer, Sebastian Victor Jansen
Summary: An in-vitro study investigated the feasibility of using a single pumping chamber of the SynCardia total artificial heart as a replacement for a single ventricle palliated by Fontan circulation. The study showed that the single-chambered TAH performed sufficiently in the setting of the Fontan circulation, even achieving higher cardiac outputs in scenarios of pulmonary hypertension. This suggests that the replacement of a failing univentricular heart by a single chamber of the SynCardia TAH may provide a successful alternative for Fontan patients.
JOURNAL OF ARTIFICIAL ORGANS
(2022)
Article
Engineering, Biomedical
Stephan Hildebrand, Mario Diedrich, Moritz Brockhaus, Thomas Finocchiaro, Elena Cuenca, Heiko De Ben, Ulrich Steinseifer, Thomas Schmitz-Rode, Sebastian Victor Jansen
Summary: The study aimed to identify the preload and afterload sensitivity of the ReinHeart TAH 2.0, showing good controllability of left-right flow balance with some adaptability.
Article
Engineering, Biomedical
Felix Hesselmann, Daniel Arnemann, Patrick Bongartz, Matthias Wessling, Christian Cornelissen, Thomas Schmitz-Rode, Ulrich Steinseifer, Sebastian Victor Jansen, Jutta Arens
Summary: Membranes based on TPMS structures have shown superior gas transfer compared to contemporary HFM designs in artificial lungs, attributed to disrupting the laminar boundary layer near the membrane surface. Hemolysis test results indicate that although there is a slight increase in hemolysis for TPMS membranes, the difference compared to HFMs is small. The ratio between additional oxygen transfer and additional hemolysis favors the TPMS-based membrane shapes, suggesting a safe way to improve gas transfer in artificial lungs.
Article
Chemistry, Physical
Patrick M. TomHon, Suyong Han, Soren Lehmkuhl, Stephan Appelt, Eduard Y. Chekmenev, Milad Abolhasani, Thomas Theis
Summary: The Spin Transfer Automated Reactor (STAR) introduced in the study can continuously produce stable parahydrogen induced polarization (PHIP) using the signal amplification by reversible exchange (SABRE) variant. Operated with both benchtop and high field NMR magnets, the STAR efficiently delivers parahydrogen into solutions for hyperpolarization of various substrates. The unique features of the STAR are leveraged for important applications, such as continuous hyperpolarization of metabolites and continuous RASER signals for exploring new physics.
Article
Biochemistry & Molecular Biology
Lasse J. Strudthoff, Hannah Lueken, Sebastian V. Jansen, Jan Petran, Peter C. Schlanstein, Lotte Schraven, Benjamin J. Schuermann, Niklas B. Steuer, Georg Wagner, Thomas Schmitz-Rode, Ulrich Steinseifer, Jutta Arens, Ruedger Kopp
Summary: Extracorporeal membrane oxygenation (ECMO) is a rescue therapy established for chronic respiratory failure patients waiting for lung transplantation (LTx), but its immobilization may lead to fatigue and deteriorated prognosis. Researchers conducted a feasibility study on a novel system designed to allow awake patients to engage in physical activity prior to surgery. The experiments showed promising results, prompting further preclinical studies for potential clinical application.
Article
Energy & Fuels
Anton Duchowny, Oliver Mohnke, Holger Thern, Pablo Matias Dupuy, Hege Christin Wideroe, Audun Faanes, Anfinn Paulsen, Markus Kueppers, Bernhard Bluemich, Alina Adams
Summary: This study demonstrates that benchtop NMR combined with chemometrics can reliably and quickly quantify complex hydrocarbon-gas mixtures.
Article
Engineering, Biomedical
Borut Kirn, Mario Diedrich, Thomas Schmitz-Rode, Ulrich Steinseifer, Sebastian V. V. Jansen
Summary: In this study, detection techniques for the preload and afterload in total artificial hearts (TAH) are developed and their reliability is evaluated across a range of cardiovascular system states. The results show that the preload estimation is reliable, especially for the left circulation, but further improvements are needed for afterload detection.
Article
Engineering, Biomedical
Jutta Arens, Lotte Schraven, Andreas Kaesler, Christian Flege, Thomas Schmitz-Rode, Rolf Rossaint, Ulrich Steinseifer, Ruedger Kopp
Summary: A new oxygenator was designed in this study, suitable for various test conditions such as blood tests, numerical simulation, and membrane studies, and can be modified in membrane area size and manufactured in laboratory. The results showed no significant difference between the tested oxygenators and the new oxygenator demonstrated good hemocompatibility. Therefore, this newly developed device is considered a valuable tool for basic experimental and numerical research on the optimization of oxygenators.
Article
Biochemical Research Methods
Dennis Woertge, Matthew Parziale, Jan Claussen, Behzad Mohebbi, Siegfried Stapf, Bernhard Bluemich, Matthew Augustine
Summary: The matrix pencil method (MPM) is tested for quantitatively processing multiexponential low-field nuclear magnetic resonance T1 relaxometry data. The data is obtained from T1 saturation recovery curves measured in a highly inhomogeneous magnetic field. Different concentrations of a Gd3+ contrast agent doped in 0.9% brine solutions are used as test liquids. MPM shows superior performance in separating and quantifying relaxation components, as well as exploring the sensitivity to relative contribution of each component and resolving systems with multiple components.
JOURNAL OF MAGNETIC RESONANCE
(2023)
Article
Chemistry, Analytical
Maria Cheremkhina, Sarah Klein, Aaron Babendreyer, Andreas Ludwig, Thomas Schmitz-Rode, Stefan Jockenhoevel, Christian G. Cornelissen, Anja Lena Thiebes
Summary: Endothelial cell aerosolization is a feasible technique for the endothelialization of gas exchange membranes in biohybrid lung applications, with no significant changes in cell behavior observed. The cell survival rate was above 90% and spraying did not affect the formation of a confluent cell layer or the ability to withstand shear stresses.
Article
Engineering, Biomedical
Frederik Dreyer, Qing Yang, Belal Alnajjar, Daniel Kruger, Bernhard Blumich, Jens Anders
Summary: This article presents a portable NMR relaxometry system optimized for the point-of-care analysis of body liquids, demonstrating excellent concentration sensitivity and making it an ideal candidate for future biomarker detection.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2023)
Article
Chemistry, Multidisciplinary
Fu-Sung Kim-Benjamin Tang, Mark Bukowski, Thomas Schmitz-Rode, Robert Farkas
Summary: The developed automated search methods can provide a first orientation for medical device manufacturers before clinical evaluation. Automated initial scoping searches can lower resource and labor costs. Automating the first literature review is necessary to prevent the disappearance of small and medium-sized enterprises and their medical devices.
APPLIED SCIENCES-BASEL
(2023)
Article
Energy & Fuels
Anton Duchowny, Karin Engelander, Bernhard Bluemich, Alina Adams
Summary: Understanding aging phenomena of alternative fuels is crucial due to the introduction of different aging-related phenomena. A novel test rig was designed to simulate real conditions and achieve knowledge gain for fuel aging and additive technology development. The results showed that pure FAME performed well in the realistic setup due to its high polarity preventing deposit accumulation. Insightful information with minimal effort and sample volume was obtained through benchtop 1H Nuclear Magnetic Resonance (NMR) spectroscopy. Conventional fuel and FAME blends were found to lead to system failures and large quantities of deposits.
JOURNAL OF THE ENERGY INSTITUTE
(2023)
