Review
Chemistry, Multidisciplinary
Amandine L. Flourat, Jeanne Combes, Claire Bailly-Maitre-Grand, Kevin Magnien, Arnaud Haudrechy, Jean-Hugues Renault, Florent Allais
Summary: p-Hydroxycinnamic acids are phenolic compounds involved in lignin biosynthesis pathway, with attractive properties such as antioxidant, anti-UV, and anticancer activities, and are used as building blocks for various industries, but their production cost remains high.
Article
Food Science & Technology
Zi-Ying Wang, Ying Yin, Dong-Ni Li, Dan-Yue Zhao, Jun-Qing Huang
Summary: The review summarizes the protective effects of p-Hydroxycinnamic acids (HCAs) on the intestinal barrier. These effects are achieved through four mechanisms: preserving tight junction proteins, modulating pro-inflammatory cytokines, exerting antioxidant activity, and regulating the intestinal microbiota.
Article
Biotechnology & Applied Microbiology
Miao Cai, Jiayu Liu, Xiaofei Song, Hang Qi, Yuanzi Li, Zhenzhou Wu, Haijin Xu, Mingqiang Qiao
Summary: This study achieved the de novo biosynthesis of p-coumaric acid and caffeic acid from lignocellulose through a co-cultivation strategy. The improved inoculation ratio and carbon source content significantly increased the production yield of these aromatic compounds.
MICROBIAL CELL FACTORIES
(2022)
Article
Biochemistry & Molecular Biology
Mohd Shahnawaz Khan, Majed S. Alokail, Amal Majed H. Alenad, Nojood Altwaijry, Nouf Omar Alafaleq, Abdulaziz Mohammed Alamri, Mubarak Ali Zawba
Summary: Alpha-amylase plays an important role in the management of diabetes and its complications. This study explored the binding of caffeic acid and coumaric acid with alpha-amylase and their effects on the formation of advanced glycation end-products (AGEs). The results showed that both compounds could bind to alpha-amylase and inhibit the formation of AGEs. Caffeic acid exhibited stronger antiglycative activity compared to p-coumaric acid, which could be attributed to its additional -OH group and high antioxidant activity. The study also highlighted the role of hydrogen bonding in the complex formation. Molecular docking studies suggested that these compounds could be utilized in the design of antidiabetic drugs.
Article
Biochemistry & Molecular Biology
Izabela Weremczuk-Jezyna, Weronika Gonciarz, Izabela Grzegorczyk-Karolak
Summary: This study evaluates the antioxidant properties and anti-inflammatory potential of polyphenolic acid-rich fractions of Dracocephalum moldavica. The diethyl ether fraction showed the highest antioxidant and anti-inflammatory activity.
Article
Horticulture
Paraskevi Roufa, Alexandra Evangelou, Evangelos Beris, Styliani Karagianni, Archontoula Chatzilazarou, Efthalia Dourtoglou, Adnan Shehadeh
Summary: This study aimed to investigate the effects of three herbs on the properties of wine. The results indicate that adding herbs during the post-fermentation stage can significantly increase the antioxidant activity and phenolic compounds of the wine.
Article
Chemistry, Physical
Gabriela Petrisor, Ludmila Motelica, Denisa Ficai, Roxana Doina Trusca, Vasile-Adrian Surdu, Georgeta Voicu, Ovidiu Cristian Oprea, Anton Ficai, Ecaterina Andronescu
Summary: In this study, two types of mesoporous silica materials with different pore structures and volumes were synthesized and loaded with three types of polyphenols. The obtained materials were characterized from a morphological and structural point of view, and the differences between the two types of materials and the changes after loading with polyphenols were observed. In vitro studies demonstrated the potential biomedical applications of these materials.
Article
Agriculture, Dairy & Animal Science
Martyna A. Posluszny, Magdalena Chlopecka, Sorphon Suor-Cherer, Sekhou Cisse, Mohamed el Amine Benarbia, Marta Mendel
Summary: Lemon balm has been traditionally used in human medicine for gastrointestinal disorders, but its effect on gut contractility in animals has not been well-studied. This study found that lemon balm extract increased gut contractility in chickens, while reducing spontaneous activity in the proximal intestine.
Article
Neurosciences
Moeko Noguchi-Shinohara, Tsuyoshi Hamaguchi, Kenji Sakai, Junji Komatsu, Kazuo Iwasa, Mai Horimoto, Hiroyuki Nakamura, Masahito Yamada, Kenjiro Ono
Summary: This study aimed to assess the effects of Melissa officinalis extract on cognition in older adults without dementia. The results showed that the extract did not have a significant impact on cognitive function. However, in participants without hypertension, there was a slight increase in the clinical dementia rating score in the Melissa officinalis group compared to a slight decrease in the placebo group, and this difference was statistically significant. Therefore, Melissa officinalis extract may help prevent cognitive decline in older adults without hypertension.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Integrative & Complementary Medicine
Ji Xiao, Ping Liu, Yuze Hu, Tao Liu, Yuying Guo, Pinghua Sun, Junxia Zheng, Zhe Ren, Yifei Wang
Summary: This study aimed to explore the anti-herpesvirus activity and mechanism of Fr.8.3 extracted from Artemisia vulgaris L. The results showed that Fr.8.3 had anti-HSV-1 activity by acting directly on the virus itself. LC-MS analysis identified the main components as 1 and 2, which may interfere with virus adhesion to cell receptors, providing new insights for drug development.
Article
Plant Sciences
Maja Hitl, Snezana Brkic, Nebojsa Kladar
Summary: Rosmarinic acid (RA) is a phenolic compound with proven health benefits, but its effectiveness is limited when taken orally due to degradation in the digestive tract. This study investigated the stability of RA under intestinal microbiota fermentation. Pure compound and lemon balm extract were used as sources of RA, and commercially available probiotics were used as sources of microorganisms. RA's content decreased significantly in some probiotics, ranging from approximately 20% to total degradation when using the pure compound. The bacterial strain Lactobacillus helveticus was found to be responsible for extensive degradation. RA is more stable in pure samples than in complex extract matrix.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Medicine, Research & Experimental
Mohsen Keshavarz, Forough Shamsizadeh, Ahmad Tavakoli, Neda Baghban, Arezoo Khoradmehr, Ali Kameli, Poorya Rasekh, Adel Daneshi, Iraj Nabipour, Katayoun Vahdat, Maryam Farrokhnia, Amin Tamadon
Summary: The ethanolic extract of Holothuria parva demonstrates significant antiviral activities against HSV-1 by reducing virus titers and interfering with virus attachment to cell receptors. Octadecanoic acid 2-hydroxy-1-(hydroxymethyl) ethyl ester and 2',6'-acetoxylidide are major constituents in the extract. Computational docking analysis suggests that the extract compounds may inhibit virus attachment by covering both virus and host cell binding domains.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Microbiology
Ronnie J. M. Lubbers, Ronald P. de Vries
Summary: Protocatechuic acid is an important chemical building block with pharmaceutical properties that can also be used to produce polymers and plastics. By identifying protocatechuate hydroxylase, it was found that a fungal cell factory can accumulate protocatechuic acid from plant-derived aromatic compounds. This research contributes to creating alternative methods for producing valuable aromatic compounds and platform chemicals.
Article
Agriculture, Multidisciplinary
Xihui Wang, Cui Zhao, Xinyao Lu, Hong Zong, Bin Zhuge
Summary: A growth-coupled dual-layered dynamic regulation system was developed to boost the yield of caffeic acid. This system autonomously controls intracellular pyruvate supply and coordinates gene expression to redirect carbon metabolism for caffeic acid synthesis. The engineered strain achieved a caffeic acid titer of 559.7 mg/L in a 5 L bioreactor, demonstrating the efficiency and potential of this system in enhancing the production of aromatic compounds.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Andresa Aparecida Berretta, Luana Goncalves Zamarrenho, Juliana Arcadepani Correa, Jessica Aparecida De Lima, Giovanna Bonfante Borini, Sergio Ricardo Ambrosio, Hernane da Silva Barud, Jairo Kenupp Bastos, David De Jong
Summary: The technologies used to produce different forms of propolis can selectively affect their chemical composition and biological activities. Three different formulations of propolis extract were developed and investigated, and they showed variations in physical appearance, chemical profile, and biological activity. Further studies should focus on the purified solid propolis with high antioxidant and antimicrobial activity.
Article
Integrative & Complementary Medicine
Akram Astani, Juergen Reichling, Paul Schnitzler
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2011)
Article
Virology
S. Brost, J. J. Wenzel, T. M. Ganten, M. Filser, C. Flechtenmacher, S. Boehm, A. Astani, W. Jilg, M. Zeier, P. Schnitzler
JOURNAL OF CLINICAL VIROLOGY
(2010)
Article
Biochemistry & Molecular Biology
Sharmistha Sinha, Akram Astani, Tuhin Ghosh, Paul Schnitzler, Bimalendu Ray
Article
Chemistry, Medicinal
Akram Astani, Mojdeh Heidary Navid, Paul Schnitzler
PHYTOTHERAPY RESEARCH
(2014)
Review
Virology
Javad Charostad, Akram Astani, Hossein Goudarzi, Ebrahim Faghihloo
REVIEWS IN MEDICAL VIROLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Nouraddin Abdi Goushbolagh, Razzagh Abedi Firouzjah, Kourosh Ebrahimnejad Gorji, Mohammadjavad Khosravanipour, Saman Moradi, Amin Banaei, Akram Astani, Masoud Najafi, Mohammad Hosein Zare, Bagher Farhood
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2018)
Review
Virology
Rana Jahanban-Esfahlan, Khaled Seidi, Maryam Majidinia, Ansar Karimian, Bahman Yousefi, Seyed Mohammad Nabavi, Akram Astani, Ioana Berindan-Neagoe, Diana Gulei, Francesca Fallarino, Marco Gargaro, Giorgia Manni, Matteo Pirro, Suowen Xu, Mahmoud Sadeghi, Seyed Fazel Nabavi, Samira Shirooie
REVIEWS IN MEDICAL VIROLOGY
(2019)
Article
Parasitology
Zohre Firoozi, Alireza Sazmand, Alireza Zahedi, Akram Astani, Ali Fattahi-Bafghi, Narges Kiani-Salmi, Behnam Ebrahimi, Arefeh Dehghani-Tafti, Una Ryan, Fateme Akrami-Mohajeri
PARASITES & VECTORS
(2019)
Article
Cell Biology
Fariba Akhondzadeh, Akram Astani, Razieh Najjari, Morteza Samadi, Mohammad Ebrahim Rezvani, Fatemeh Zare, Ali Mohammad Ranjbar, Fatemeh Safari
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Obstetrics & Gynecology
Khadije Rezai Khanmohammad, Mohammad Bagher Khalili, Maryam Sadeh, Ali Reza Talebi, Akram Astani, Ali Shams, Fateme Zare
Summary: The study found that LPS can stimulate the immune system to produce proinflammatory cytokines, resulting in an immune response in the testis and ultimately leading to deficiency in sperm parameters and testis tissue damage. Additionally, the presence of LPS significantly impair sperm parameters, as shown by the finding of decreased motility.
CLINICAL AND EXPERIMENTAL REPRODUCTIVE MEDICINE-CERM
(2021)
Article
Chemistry, Medicinal
A. Astani, U. Albrecht, P. Schnitzler
Article
Microbiology
Akram Astani, Paul Schnitzler
IRANIAN JOURNAL OF MICROBIOLOGY
(2014)
Article
Chemistry, Medicinal
A. Astani, S. Zimmermann, E. Hassan, J. Reichling, K. H. Sensch, P. Schnitzler
Article
Chemistry, Medicinal
M. Sharaf, A. Amara, A. Aboul-Enein, S. Helmi, A. Ballot, A. Astani, P. Schnitzler