期刊
CHEMOTHERAPY
卷 54, 期 3, 页码 176-180出版社
KARGER
DOI: 10.1159/000140361
关键词
albumin-interferon-alpha; albumin-interferon-beta; bioterrorism; RNA virus
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [N01AI085348] Funding Source: NIH RePORTER
- NIAID NIH HHS [N01-AI-85348] Funding Source: Medline
Background: The type 1 interferons (INF-alpha and INF-beta) are potent antiviral agents. Albumin-INF-alpha and albumin-INF-beta are novel recombinant proteins consisting of IFN-alpha or IFN-beta genetically fused to human albumin. Methods: The in vitro antiviral activity of albumin-IFN-alpha was evaluated against representative bioterrorism viral agents and the severe acute respiratory syndrome virus. Antiviral activity was assessed using inhibition of cytopathic effect and neutral red staining. Results: EC50 values for albumin-IFN-alpha ranged from < 0.1 ng/ml for Punta Toro virus to 65 ng/ml for Venezuelan equine encephalitis virus in the neutral red assay. Albumin-IFN-beta showed 75- and 360-fold greater in vitro activity than albumin-IFN-alpha against Ebola virus and severe acute respiratory syndrome, respectively. Conclusion: Further evaluation of these long-acting albumin-IFN fusion proteins as prophylactic or therapeutic agents against these viral agents of bioterrorism in relevant primate models is warranted. Copyright (C) 2008 S. Karger AG, Basel.
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