Article
Marine & Freshwater Biology
Matthew T. Barbour, Justin R. Schueller, Todd J. Severson, Jeremy K. Wise, Matthew J. Meulemans, James A. Luoma, Diane L. Waller
Summary: Researches focused on the synergistic effects of toxicant mixtures in controlling aquatic invasive species have shown that using synergistic combinations can decrease the overall volume and concentration of individual toxicants required for treatments, thereby reducing costs.
AQUATIC TOXICOLOGY
(2021)
Article
Chemistry, Physical
Tingting Guo, Xiaojuan Wang, Yang Shu, Jianhua Wang
Summary: This study evaluated the behavior of 1-alkyl-3-methylimidazolium dicyanamide ionic liquids with different alkyl side-chain lengths, showing that longer alkyl side-chains increased toxicity. The findings provide insight into the potential hazards of ILs and their interactions with proteins and cells.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Multidisciplinary
Yui Kato, Takuya Uto, Daisuke Tanaka, Kojiro Ishibashi, Akiko Kobayashi, Masaharu Hazawa, Richard W. Wong, Kazuaki Ninomiya, Kenji Takahashi, Eishu Hirata, Kosuke Kuroda
Summary: Cell cryopreservation is essential for long-term storage, but some cell lines cannot be efficiently cryopreserved. Research shows that a synthetic zwitterion solution can achieve good cryopreservation, but not with high efficiency for certain cells. Further study on the cryoprotective effects and mechanisms of zwitterions is needed for optimization and better results.
COMMUNICATIONS CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yui Kato, Yuya Matsuda, Takuya Uto, Daisuke Tanaka, Kojiro Ishibashi, Takeru Ishizaki, Akio Ohta, Akiko Kobayashi, Masaharu Hazawa, Richard W. Wong, Kazuaki Ninomiya, Kenji Takahashi, Eishu Hirata, Kosuke Kuroda
Summary: During long-term cell storage, the addition of cryoprotectants to inhibit ice crystal formation is necessary. However, the high osmotic pressure and dehydration caused by non-cell-permeable cryoprotectants often damage cells. In this study, researchers developed a poly(zwitterion) isotonic cryoprotectant that forms a firm matrix around cells, preventing the influx of ice crystal nuclei without the need for high osmotic pressure and dehydration.
COMMUNICATIONS CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Malgorzata Musia, Edward Zorebski, Katarzyna Malarz, Michal Kuczak, Anna Mrozek-Wilczkiewicz, Johan Jacquemin, Marzena Dzida
Summary: The study revealed that imidazolium-based ILs combined with dialkyl phosphate anions or with the ethyl sulfate anion are the least cytotoxic. Some ILs can potentially be used as hydraulic fluids or efficient solvents, while others have potential as heat transfer media and base fluids.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Review
Biochemistry & Molecular Biology
Ana R. P. Goncalves, Xavier Paredes, A. F. Cristino, F. J. V. Santos, Carla S. G. P. Queiros
Summary: Ionic liquids were initially touted as environmentally friendly replacements for traditional solvents, but research on their interactions with organisms is lacking. Lipophilicity and the type of cation play key roles in toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Madhur Babu Singh, Pallavi Jain, Preeti Chaudhary, Indra Bahadur, Kashmiri Lal, Vinod Kumar, Prashant Singh, Himani, Anirudh Pratap Singh Raman
Summary: Ionic liquids (ILs) have a wide range of features, uses, and environmentally friendly nature, making them potential substitutes for organic solvents in addressing pollution. ILs possess unique thermal, physical, chemical, and biological properties, which can be modified by altering their cationic and anionic parts. Their applications in protein stabilization, organic transformation, nanomaterials, etc., indicate their significant impact on research and development.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Marika Turek, Robert Biczak, Barbara Pawlowska, Ewa Rozycka-Sokolowska, Krzysztof Owsianik, Bernard Marciniak, Piotr Balczewski
Summary: The use of optically active forms of commercial chiral herbicides may be more effective and environmentally safer. This study synthesized a series of chiral quaternary ammonium salts and investigated their selective toxicity towards aquatic bacteria and terrestrial plants. The results showed that these salts exhibited enantioselective toxicity towards all tested organisms.
Article
Green & Sustainable Science & Technology
Sergio S. de Jesus, Rubens Maciel Filho
Summary: Ionic liquids are molten salts with excellent chemical and thermal stability, which have the potential to replace traditional organic solvents. However, their synthesis, toxicity, and biodegradability pose challenges to their environmentally friendly use. Analyzing the processes of synthesis, recovery and recycling, toxicity, and biodegradability reveals the need for further improvements in ionic liquid design to meet the principles of green chemistry.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2022)
Article
Engineering, Environmental
Viresh Thamke, Prashant Singh, Shweta Pal, Mansi Chaudhary, Kamlesh Kumari, Indra Bahadur, Rajender S. Varma
Summary: Ionic liquids (ILs) are widely used solvents in various fields, but their potential environmental contamination and toxicological impact have become increasingly important. This review article summarizes the recent toxicological effects of newly synthesized ILs on different organisms, including microbes, vertebrates, and plants, and discusses the development of computational modeling for toxicity testing.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Environmental Sciences
Martin McLaughlin, Manuela A. Gilea, Martyn J. Earle, Kenneth R. Seddon, Brendan F. Gilmore, Stephen A. Kelly
Summary: The study found that ILs with longer alkyl chains exhibited greater biocidal activity at relevant concentrations, comparable to commonly used biocides. The primary cytotoxic mechanism was determined to be necrosis, with apoptosis observed at lower concentrations. The modification of anion significantly affected cytotoxicity, indicating that cytotoxicity may be a tuneable property when using ILs as biocides.
Review
Environmental Sciences
Chul-Woong Cho, Thi Phuong Thuy Pham, Yufeng Zhao, Stefan Stolte, Yeoung-Sang Yun
Summary: Interest in ionic liquids (ILs) has been growing due to their promising properties, but their actual environmental impact needs careful consideration. ILs may not directly cause atmospheric pollution, but can have adverse effects if leaked into the environment. The toxicity effects of ILs depend on their structure and toxicity testing levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Li-Tang Qin, Min Liu, Xin Zhang, Ling-Yun Mo, Hong-Hu Zeng, Yan-Peng Liang
Summary: The study investigated the toxicological interactions of HAA mixtures in green algae and predicted DBP mixture toxicities based on different models. Results showed that mixture effects were synergistic in 47.1% and antagonistic in 25%, while additive effects were only observed in 27.9% of experiments. Predictive models failed to accurately predict mixture toxicity.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2021)
Article
Chemistry, Physical
Malgorzata Pajak, Katarzyna Hubkowska, Andrzej Czerwinski
Summary: The mixtures of selected protic and aprotic ionic liquids with their parent superacids were used as electrolytes for hydrogen electrosorption in thin Pd films. The properties of these mixtures were characterized using electrochemical and physicochemical methods, demonstrating their potential use as electrolytes in hydride/protonic systems.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Engineering, Environmental
Yan Wang, Kaiyuan Xue, Xingyun Zhang, Xu Zhang, Bingjun Yang, Shusheng Xu, Junwei Lang
Summary: This research successfully realizes the in-situ monitoring of energy storage behavior of independent ions using polymeric ionic liquids. It is found that large-sized polymeric imidazole cations cannot enter the active carbon pores, while free anions can. The study also reveals that ion adsorption/desorption is governed by the electrostatic attraction and repulsion of charged particles.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Environmental Sciences
Jin Zhang, Tao Wang, Longke Ban, Zhiqiang Bian, Fakang Pan
Summary: The study investigated the toxic effects and mechanisms of heavy metals on Chlorella, revealing that antagonistic effects vary with time and components, and chlorophyll-a reduction rates differ under the influence of different heavy metals. The toxicity mechanism of copper on algal cells involves damaging cell membranes and chloroplast structures.
POLISH JOURNAL OF ENVIRONMENTAL STUDIES
(2021)
Article
Environmental Sciences
Yu Wang, Shu-Shen Liu, Peng Huang, Ze-Jun Wang, Ya-Qian Xu
Summary: This study systematically evaluated the locomotion behavioral toxicities of carbamate pesticides (CMs) and organophosphorus pesticides (OPs) on Caenorhabditis elegans, and found that they produce significant inhibitory effects on the locomotion behavior of the nematodes, with OPs showing higher toxicity than CMs. Toxicological interactions in the binary CM and OP mixtures were found to be different from each other, highlighting the importance of examining multiple concentration ratios rather than relying on just one.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Ting-Ting Ding, Shi-Lin Du, Zi-Yan Huang, Ze-Jun Wang, Jin Zhang, Ya-Hui Zhang, Shu-Shen Liu, Lian-Sheng He
Summary: This study conducted ammonia toxicity tests and established water quality criteria in the Shaying River Basin, finding severe ecological risks of ammonia to aquatic species, with the risk ranking as wet season > flat season > dry season.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Ze-Jun Wang, Qiao-Feng Zheng, Shu-Shen Liu, Peng Huang, Ting-Ting Ding, Ya-Qian Xu
Summary: This study focuses on predicting mixture toxicity based on single substances or low component mixtures using concentration addition (CA) and independent action (IA) models. Two top-to-down methods, inverse CA (ICA) and inverse IA (IIA) models, were proposed to eliminate the effects of specific components from mixtures. The results showed that cosolvent IPA with hormesis may cause unpredictable effects, while DMSO effectively eliminates the effects of toxic components from mixtures. These methods provide a new framework for mixture toxicity evaluation and risk assessment.
Article
Environmental Sciences
Peng Huang, Shu-Shen Liu, Ze-Jun Wang, Ting-Ting Ding, Ya-Qian Xu
Summary: The widespread use of pesticides raises concerns about their impact on the environment and human health. This study developed a new method using QSAR and SSD models to assess the environmental risks of 35 pesticides. By combining these models, reliable predicted no effect concentrations (PNEC) were derived, even when there was limited toxicity data available for certain chemicals.
Article
Environmental Sciences
Yueheng Zhang, Qing Gao, Shu-shen Liu, Liang Tang, Xin-Gui Li, Haoyu Sun
Summary: Quinolones, dechloranes, and chlorinated paraffins are new types of halogenated organic pollutants that come from flame retardants, lubricants, and pesticides. This study investigates the toxic effects of these pollutants on cyanobacteria, particularly Microcystis aeruginosa, and finds that quinolones and dechloranes have hormetic effects on their proliferation, while chlorinated paraffins do not. The joint toxicity tests show that mixtures of quinolones & chlorinated paraffins and dechloranes & chlorinated paraffins also exhibit hormetic effects on Microcystis aeruginosa. However, mixtures of quinolones & dechloranes do not have a hormetic effect. It is also found that mixtures of quinolones & dechloranes have synergistic toxic actions, while the joint toxic actions of both quinolones & chlorinated paraffins, and dechloranes & chlorinated paraffins shift from addition to antagonism with increasing concentration. The study provides important data and mechanisms for understanding the hormetic phenomenon of these pollutants on Microcystis aeruginosa and highlights the role of hormesis in the risk assessment of environmental pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Multidisciplinary
Sheng Lu, Peng Huang, Shu-Shen Liu, Ze-Jun Wang
Summary: This study investigated the effect of introducing eugenol on the combined toxicities of flavor mixtures. The results showed that the addition of eugenol attenuated the synergistic toxicological interactions of flavor mixtures, transforming them into additive action and even antagonistic interactions.
Article
Environmental Sciences
Peng Huang, Yu Wang, Shu-Shen Liu, Ze-Jun Wang, Ya-Qian Xu
Summary: This study explores the interaction of pesticide mixtures on Caenorhabditis elegans behavioral toxicity endpoint by creating a synergistic-antagonistic heatmap. The results show significant concentration-response relationship and strong synergism among the toxic chemicals. The emergence of synergism raises concerns about these hazardous chemicals.
ENVIRONMENTAL POLLUTION
(2022)
Article
Engineering, Environmental
Chao Fang, Xinmiao Luan, Feiyang Ao, Xingyu Wang, Shunke Ding, Zhenqi Du, Shushen Liu, Ruibao Jia, Wenhai Chu
Summary: In this study, it was discovered that the level of TOX in chlorinated waters had been significantly underestimated under common analytical conditions. The addition of quenching agent sodium thiosulfate resulted in a two-phase decomposition pattern of total organic chlorine and total organic bromine, indicating the important toxicological significance of the DBPs responsible for TOX decomposition. Nontarget analysis using high-resolution mass spectrometry revealed the molecular formulas for the decomposed TOX, and it was found that the level of unknown TOX in chlorinated waters was considerably higher than previously thought.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Ya-Qian Xu, Kai Li, Ze-Jun Wang, Peng Huang, Shu-Shen Liu
Summary: This study investigates the transfer of hormesis between chemical components and personal care product mixtures and identifies a key compound, betaine, affecting hormesis transfer. The study finds that only mixture rays containing at least one hormesis-inducing compound produce hormesis to the freshwater photobacterium Q67. The study also suggests that betaine triggers the quorum sensing pathway, contributing to hormetic effects. This research provides new insights into hormesis and its mixtures, and offers an efficient method to identify potential components that affect hormesis transfer in mixtures.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Ting-Ting Ding, Shu-Shen Liu, Ze-Jun Wang, Peng Huang, Zhong-Wei Gu, Meng -Ting Tao
Summary: The GSA-qHTS technique for screening toxic factors in complex mixtures suffers from unequal factor levels, leading to asymmetry in the importance of elementary effects. A new method called EFSFL was developed to achieve equal frequency sampling of factor levels, and important factors affecting mixture toxicities were screened using high-throughput microplate toxicity analysis and elementary effect analysis.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Peng Huang, Shu-Shen Liu, Ze-Jun Wang, Ting-Ting Ding, Meng-Ting Tao, Zhong-Wei Gu
Summary: With the widespread use of pesticides, the cocktail effect caused by the coexistence of multiple low-residue pesticides in the environment has become a concern. However, limited information on the modes of action (MOAs) of chemicals hinders the application of concentration addition (CA) models in evaluating and predicting the toxicity of mixtures with similar MOAs. This study characterized the similarity of pesticide MOAs using MEDV-13 descriptors and established methods to test the toxicity of mixtures on the lifespan and reproduction of Caenorhabditis elegans. The results showed consistent toxicity interactions of the mixtures on the nematode's lifespan and reproductive endpoints.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Xiao Sun, Ting-Ting Ding, Ze-Jun Wang, Peng Huang, Shu-Shen Liu
Summary: In this study, the application of the species sensitivity distribution (SSD) for ecological risk assessment of persistent organic pollutants (POPs), specifically polycyclic aromatic hydrocarbons (PAHs), is improved by exploring the use of acute SSD curves to derive chronic predicted no-effect concentrations (PNECs) and calculating PNECs using HC10 instead of HC5. The results show that the chronic PNEC for PAHs can be estimated by multiplying the acute PNEC by 0.1 and the assessment factor for HC10 is 10. The obtained chronic PNECs based on acute HC10 values for specific PAHs are reported.
Article
Chemistry, Analytical
Jian-ping Zeng, Jin Zhang, Na-na Zhou, Hui-yan Shen, Gui-yun Hong
Summary: Cosmetic additives and packaging plasticizers as emerging pollutants may pose potential risks and dangers to the environment and human body. The toxicity of these pollutants and their mixtures were studied using Vibrio qinghaiensis sp.-Q67 as the test organism, and it was found that these substances exhibited concentration-dependent toxicity and the mixtures showed primarily antagonistic interactions. The concentration ratio of the components played a decisive role in the type of interaction observed.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2023)
Article
Engineering, Environmental
Ting-Ting Ding, Shu-Shen Liu, Ze-Jun Wang, Peng Huang, Meng-Ting Tao, Zhong-Wei Gu
Summary: Global sensitivity analysis combined with quantitative high-throughput screening provides a novel technique for identifying the key components responsible for the toxicities of mixtures. However, the current designs suffer from uneven frequency sampling, repeated mixtures, and only considering odd factor levels. To address these issues, the study proposes a method called LHS-OAT, which uses latin hypercube sampling to achieve equal frequency sampling and non-repeated mixtures, and applies different one factor at a time methods for factors with odd and even levels. The method was successfully applied to design mixtures of antibiotics and pesticides, accurately identifying the important factors inducing the toxicities of the mixtures.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
