Article
Environmental Sciences
Sridhar Chinthakindi, Kurunthachalam Kannan
Summary: This study investigated the presence of AAs and tobacco chemical markers in pet urine and feces samples. The findings suggested that pets are exposed to AAs, but have low concentrations of nicotine and cotinine. Cats and dogs are more likely to be exposed to AA precursors.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Food Science & Technology
Borja Munoz-Solano, Elena Gonzalez-Penas
Summary: Mycotoxins are a major concern for food safety, as their exposure in animals can lead to health problems, economic losses, and contamination of animal-derived foods. This study used a revalidated methodology to analyze mycotoxins in animal plasma samples, finding that the prevalence of STER was high but levels were low in the analyzed feed. Animal biomonitoring can be a useful tool in assessing mycotoxin exposure, but more research is needed on appropriate biomarkers and analytical methods.
Article
Biochemistry & Molecular Biology
Mihaela Butiulca, Lenard Farczadi, Camil Eugen Vari, Silvia Imre, Mihai Pui, Alexandra Lazar
Summary: This study aimed to develop a sensitive, selective, and accurate LCMS/MS method for biomonitoring ropivacaine and its main metabolite in plasma after regional anesthesia. The validation of the method showed its suitability for monitoring purposes, and potential for application in similar settings. The study included one patient undergoing plane block anesthesia for cardiac device implantation, demonstrating the method's practicality in real-world scenarios.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Chemistry, Analytical
Xuefei Zhong, Shruti Nayak, Lili Guo, Shivkumar Raidas, Yunlong Zhao, Rachel Weiss, Matthew Andisik, Chinnasamy Elango, Giane Sumner, Susan C. Irvin, Michael A. Partridge, Hong Yan, Sook E. Yen, Haibo Qiu, Yuan Mao, Albert Torri, Ning Li
Summary: REGEN-COV, a cocktail of two human monoclonal antibodies, has shown promising results in reducing SARS-CoV-2 viral load in COVID-19 patients. A liquid chromatography-mass spectrometry method was developed for the determination of REGEN-COV concentrations in serum samples from patients participating in clinical trials. The concentrations measured by this method were comparable to those measured by a validated immunoassay.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Jose Fernando Huertas-Perez, Pascal Mottier, Quentin Basle, Shi Ying Tan, Monika Kopec-Durska, Patrycja Zawada, Antoinette Burton, Ashley Griffin, Maria Guadalupe Sanchez-Calderon
Summary: This study evaluated an analytical procedure for routine monitoring of chlorate and perchlorate in a broad range of food matrices, using liquid chromatography tandem mass spectrometry. The method demonstrated high accuracy and is suitable for monitoring in various food matrices.
MICROCHEMICAL JOURNAL
(2022)
Article
Biochemical Research Methods
Sridhar Chinthakindi, Kurunthachalam Kannan
Summary: A bioanalytical method utilizing liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed to determine trace levels of 39 primary aromatic amines and nicotine/cotinine in human urine. The method demonstrated excellent linear dynamic range and precision, and was successfully applied in the analysis of urine samples from the general population and known smokers.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Biochemical Research Methods
Reiko Iwano, Machiko Toki, Junko Hanakawa, Yumi Asakura, Masanori Adachi, Yukichi Tanaka, Koji Muroya
Summary: Thyroid dysfunction is common in Down syndrome patients. The study developed a new method to quantify thyroid hormone levels in these patients and found differences in TT3 and rT3 concentrations among different age groups. Further investigation is needed to explain these findings.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Toxicology
Nikola Pluym, Nadine Roegner, Oliver Peschel, Edgar Leibold, Gerhard Scherer, Max Scherer
Summary: In this study, a human biomonitoring method was developed to detect TMDD. Through metabolism study and urine analysis, 1-OH-TMDD was identified as a biomarker of exposure, and it was found that TMDD is rapidly metabolized and mainly excreted via urine. This method can be applied for biomonitoring of the general population.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
E. Piva, A. Giorgetti, P. Ioime, L. Morini, F. Freni, F. Lo Faro, F. Pirani, M. Montisci, P. Fais, J. P. Pascali
Summary: There are geographical differences in the presence and prevalence of PFAS in the hair of the Italian population, with hair analysis being a useful tool for assessing PFAS exposure on a regional scale. However, no significant differences in the amount of PFAS were observed based on gender or age groups.
Article
Cell Biology
Magdalena Surman, Sylwia Kedracka-Krok, Magdalena Wilczak, Piotr Rybczynski, Urszula Jankowska, Malgorzata Przybylo
Summary: Proteins carried by tumor-derived vesicles play an important role in cancer progression and have potential as diagnostic markers. This study compared protein content between vesicles released by normal and cancerous thyroid cells, and investigated the effects of these vesicles on other cells. The results showed that cancer-derived vesicles contained more proteins, some of which were unique and may be useful for thyroid cancer diagnosis and treatment. Additionally, these vesicles were found to promote cell proliferation and migration.
Article
Biochemical Research Methods
Rongmei Huang, Yi Hong, Yike Wu, Weifeng Li, Wenlan Liu
Summary: We developed a new LC-MS/MS method for simultaneous determination of serum testosterone and free testosterone levels. The method is simple to perform and can be applied in clinical practice, providing important information for diagnosis, treatment, and monitoring of androgen-related diseases.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Tengfei Yuan
Summary: In this study, a sample-multiplexing LC-MS/MS method was developed and validated for the quantification of serum estrogens. The method demonstrated high accuracy and precision, and allowed simultaneous analysis of E1, E2, and E3.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Garth Campbell, Andrea Mannetje, Samuel Keer, Geoff Eagleshama, Xianyu Wang, Chun-Yin Lin, Peter Hobson, Leisa-Maree Toms, Jeroen Douwes, Kevin V. Thomas, Jochen F. Mueller, Sarit Kaserzon
Summary: This study analyzed urine samples from the Australia and New Zealand region and obtained data on the concentrations of glyphosate and its degradation product aminomethylphosphonic acid (AMPA). The results showed that glyphosate was detected in 8% of the urine samples from the Australian general population and in 96% of urine samples from New Zealand farmers. This indicates a widespread presence of glyphosate in the population, with higher detections among farmers.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Pharmacology & Pharmacy
Kevin McKinski, Dean McNulty, Francesca Zappacosta, Mary Birchler, Matt Szapacs, Christopher Evans
Summary: ICOS, expressed on the surface of activated T-cells, is being investigated as a potential therapeutic target. Recent studies found aberrant increases in sICOS in disease-state patients using commercial ELISA kits, but the results were not consistent with in-house immunoassays. The researchers developed a novel LC-MS/MS method to confirm the results and demonstrated that sICOS is a low abundance soluble protein.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Article
Engineering, Environmental
Heidelore Fiedler, Mohammad Sadia, Thomas Krauss, Abeer Baabish, Leo W. Y. Yeung
Summary: According to the global monitoring plan, PFHxS was detected in 17% of the national samples and none in Brazil, while PFOA and PFOS had detection frequencies of 100% and 92%, respectively. Wealthier countries had higher PFOA concentrations. Some countries have achieved a 50% decrease in concentrations within ten years.
FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING
(2022)
Article
Environmental Sciences
Laura E. Jones, Akhgar Ghassabian, David A. Lawrence, Rajeshwari Sundaram, Edwina Yeung, Kurunthachalam Kannan, Erin M. Bell
Summary: The study found that infant exposure to PFOA and PFOS is associated with disruptions in immunoglobulin levels, with PFOA negatively correlated with IgE and positively correlated with IgG2, IgM, and IgA. However, there was no relation between PFOS and immunoglobulin levels.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Vineet Kumar Pal, Kurunthachalam Kannan
Summary: This study is the first to report VOCM concentrations in urine of pet dogs and cats, highlighting the need to identify sources and health implications of VOCs exposure in these animals.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Mengqi Yan, Hongkai Zhu, Yumeng Shi, Ke Xu, Shucong Chen, Qiang Zou, Hongwen Sun, Kurunthachalam Kannan
Summary: This study found the simultaneous presence of multiple flame retardants in indoor dust collected from Tianjin, China, with organophosphate flame retardants being the most dominant. The study also identified multiple sources of flame retardants in the indoor microenvironment and suggested the need for continued monitoring and efforts to reduce exposure through dust ingestion.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Hongxiu Liu, Yuyan Wang, Kurunthachalam Kannan, Mengling Liu, Hongkai Zhu, Yu Chen, Linda G. Kahn, Melanie H. Jacobson, Bo Gu, Shilpi Mehta-Lee, Sara G. Brubaker, Akhgar Ghassabian, Leonardo Trasande
Summary: This study aimed to identify the food groups and demographic factors that predict phthalate exposure in an urban contemporary pregnancy cohort in the US. The results showed that urinary metabolite levels of phthalates in pregnant women in NYC varied by age, marital status, seasonality, race/ ethnicity, and diet.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Yumeng Shi, Shucong Chen, Mengqi Yan, Zhipeng Cheng, Leicheng Zhao, Yarui Liu, Bo Zhang, Hongkai Zhu, Tao Zhang, Kurunthachalam Kannan
Summary: Nitrogenous flame retardants (NFRs) have raised global concern due to their nephrotoxic effect, but the mechanism of exposure-induced kidney injury remains unknown. This study measured eight NFRs, four oxidative stress biomarkers (OSBs), and one kidney injury biomarker (NGAL) in urine samples collected from residents in e-waste disassembly and reference areas. Higher concentrations of NFRs and biomarkers were found in the urine of e-waste site residents, indicating that chronic exposure to NFRs can induce oxidative stress and kidney damage. Structure equation modeling revealed that oxidative stress mediated a significant portion of the effect of NFRs on NGAL in e-waste related people. Overall, this study suggests the long-term chronic exposure to NFRs can lead to oxidative stress and renal injury in humans, but the pathogenesis may be scenario-specific.
Article
Environmental Sciences
Alison G. Paquette, Samantha Lapehn, Sophie Freije, James MacDonald, Theo Bammler, Drew B. Day, Christine T. Loftus, Kurunthachalam Kannan, W. Alex Mason, Nicole R. Bush, Kaja Z. LeWinn, Daniel A. Enquobahrie, Carmen Marsit, Sheela Sathyanarayana
Summary: This study provides the first human transcriptomic assessment of PAHs in the placenta and identifies associations between prenatal PAH exposure and placental gene expression, shedding light on the mechanisms by which PAHs may disrupt placental function.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Biochemical Research Methods
Zhong-Min Li, Mathusa Lakuleswaran, Kurunthachalam Kannan
Summary: In this study, a method using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed for the determination of various disinfectants, including BACs, ATMACs, DDACs, and QACs, in human serum and urine. The method involved the use of isotopically labelled internal standards and solid-phase extraction. Different LC columns were utilized for the separation of different compounds. The method showed good sensitivity and accuracy, and it was able to detect the presence of QACs and their metabolites in human serum and urine.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Article
Environmental Sciences
Zorimar Rivera-Nunez, Carolyn W. Kinkade, Leena Khoury, Jessica Brunner, Hannah Murphy, Christina Wang, Kurunthachalam Kannan, Richard K. Miller, Thomas G. O'Connor, Emily S. Barrett
Summary: The study found that maternal serum levels of poly- and perfluoroalkyl substances (PFAS) are associated with sex steroid hormone levels during pregnancy. Specifically, PFHxS is associated with increased testosterone levels in male fetuses, while PFNA and PFDA are associated with increased free testosterone levels in male fetuses. For female fetuses, PFHxS is associated with increased levels of estradiol and estriol. No associations were found for PFOS and PFOA.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Abigail Gaylord, Emily S. Barrett, Sheela Sathyanarayana, Shanna H. Swan, Ruby H. N. Nguyen, Nicole R. Bush, Kecia Carroll, Drew B. Day, Kurunthachalam Kannank, Leonardo Trasande
Summary: This study investigated the influence of prenatal exposure to the endocrine disrupting chemical bisphenol A on childhood atopic disease. The results showed that there were inverse associations between first trimester bisphenol A concentration and food allergy, while second trimester bisphenol A concentration was positively associated with food allergy. Additionally, prenatal exposure to bisphenol S was found to increase the risk of asthma among males.
ENVIRONMENTAL RESEARCH
(2023)
Article
Engineering, Environmental
Wei Wang, Kurunthachalam Kannan
Summary: This study collected 72 single-use medical products of four categories from a hospital in New York State in 2015 and analyzed their migration of 10 phthalates in an ethanol/water mixture. The results showed that the leached phthalate concentration ranged from 0.04 to 54,600 μg, with DEHP being the major phthalate found in 99% of the samples. DEHP was also found in notable concentrations in products labeled as DEHP-free. The study calculated the direct exposure to phthalates from medical devices and first aid supplies, as well as dermal intake from creams/lotions.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Henglin Zhang, You Wang, Huimin Zhu, Shaoyou Lu, Yu Wang, Jingchuan Xue, Tao Zhang, Kurunthachalam Kannan, Hongwen Sun
Summary: This study investigated the exposure of infants in South China to neonicotinoid insecticides (NEOs). The results showed that infants had detectable levels of NEOs in urine and blood samples, breast milk, infant formula, and tap water. The concentrations of specific NEOs varied in different samples, with dinotefuran and imidacloprid being the most abundant in urine, blood, breast milk, infant formula, and tap water. Older infants had higher NEO exposure than younger infants. Blood samples had higher concentrations of NEOs compared to urine samples, indicating that NEOs readily enter the bloodstream. Breast-fed infants had higher exposure levels than formula-fed infants. The study also found that external sources contributed to the majority of NEO exposure in infants.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Zhong-Min Li, Kurunthachalam Kannan
Summary: This study investigated the occurrence of synthetic chemicals including DPG, DTG, and TPG in indoor dust samples from 332 locations in 11 countries. DPG was detected in all dust samples, with varying concentrations among the countries. DPG accounted for over 87% of the total concentrations of the three compounds in all countries.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Zhong-Min Li, Kurunthachalam Kannan
Summary: A method using high-performance liquid chromatography-tandem mass spectrometry was developed for the quantification of Diphenylguanidine, 1,3-di-o-tolylguanidine, and 1,2,3-triphenylguanidine in human urine. The method had detection and quantification limits ranging from 0.002 to 0.02 ng/mL and 0.005 to 0.05 ng/mL, respectively. The method was applied to real human urine samples, revealing a detection frequency of 73% and a median concentration of 0.05 ng/mL for Diphenylguanidine in children's urine samples, and a detection frequency of 20% in adults' urine samples.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Vishal Midya, Cecilia Sara Alcala, Elza Rechtman, Jill K. Gregory, Kurunthachalam Kannan, Irva Hertz-Picciotto, Susan L. Teitelbaum, Chris Gennings, Maria J. Rosa, Damaskini Valvi
Summary: A study investigates the interactions between environmental chemicals (ECs) and their association with autism spectrum disorder (ASD). By combining weighted quantile sum regression and machine learning methods, two potential interactions between specific ECs and ASD diagnosis are identified.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Mengqi Yan, Hongkai Zhu, Haining Luo, Tao Zhang, Hongwen Sun, Kurunthachalam Kannan
Summary: This study analyzed urine samples collected from 12 cities in mainland China to determine the concentrations of volatile organic compounds (VOCs) and oxidative stress biomarkers. The results showed that VOC exposure primarily came from cooking, solvents, and vehicle emissions. Regional variations in VOC concentrations were observed, with higher levels found in North and South China. The study also revealed a positive correlation between most VOCs and oxidative stress markers, suggesting potential health risks associated with VOC exposure.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
