Article
Multidisciplinary Sciences
Jan M. Suski, Nalin Ratnayeke, Marcin Braun, Tian Zhang, Vladislav Strmiska, Wojciech Michowski, Geylani Can, Antoine Simoneau, Konrad Snioch, Mikolaj Cup, Caitlin M. Sullivan, Xiaoji Wu, Joanna Nowacka, Timothy B. Branigan, Lindsey R. Pack, James A. DeCaprio, Yan Geng, Lee Zou, Steven P. Gygi, Johannes C. Walter, Tobias Meyer, Piotr Sicinski
Summary: CDC7 is dispensable for cell division, while CDK1 is active during G1/S transition and performs functionally redundant roles with CDC7.
Article
Polymer Science
Whirang Cho, John R. Shields, Laura Dubrulle, Katrina Wakeman, Ashish Bhattarai, Mauro Zammarano, Douglas M. Fox
Summary: In this study, two chitosan-based flame retardant coatings were prepared through ionic crosslinking and their thermal properties and flammability were investigated. The coatings showed significant improvement in fire resistance and good compatibility with other top coats.
POLYMER DEGRADATION AND STABILITY
(2022)
Review
Biochemistry & Molecular Biology
Menno ter Huurne, Hendrik G. Stunnenberg
Summary: During early embryonic development, the rapid increase in cell number and the expression of genes that control developmental decisions are tightly regulated and interconnected processes. Transcription factors and signaling pathways play a crucial role in maintaining pluripotency and cell cycle progression, while canonical cell cycle regulators impact molecular networks controlling pluripotency and lineage specification.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Microbiology
Boris Bogdanow, Quang Vinh Phan, Luder Wiebusch
Summary: Cytomegaloviruses induce significant changes in cell cycle regulation to enable replication of their DNA genomes. They establish a unique cell cycle arrest at the G(1)/S transition, while activating S phase-specific gene expression and nucleotide metabolism. Despite similarities in cell cycle regulation between human and murine CMVs, there are considerable differences in viral cell cycle effectors and mechanisms of action.
Article
Multidisciplinary Sciences
Brian DeVeale, Leqian Liu, Ryan Boileau, Jennifer Swindlehurst-Chan, Bryan Marsh, Jacob W. Freimer, Adam Abate, Robert Blelloch
Summary: This study reveals the cell cycle structure of pluripotent embryonic stem cells and the relationship between G1/S restriction point, gene expression, and cellular differentiation. By genetically manipulating G1/S restriction point regulators miR-302 and P27, the researchers found that they can accelerate or delay the onset of phasic gene expression in mouse embryos. Additionally, loss of miR-302-mediated p21 or p27 suppression expedites embryonic stem cell differentiation, while a mutated Cyclin E blocks it. These findings provide new insights into our understanding of cellular differentiation.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Pooya Naseri-Nosar, Maciej T. Nogalski, Thomas Shenk
Summary: Following human cytomegalovirus (HCMV) infection, the aryl hydrocarbon receptor (AhR) is activated and alters the levels of numerous RNAs, including those related to cell cycle progression. AhR knockdown alleviates the G1/S cell cycle block in HCMV-infected fibroblasts, providing mechanistic insight into the virus-host cell interaction.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Yiming Lei, Xuan Xu, Huiling Liu, Lingjun Chen, Haoxiong Zhou, Jie Jiang, Yidong Yang, Bin Wu
Summary: The protein ARBB1 plays a critical role in HBV-related hepatocellular carcinoma by modulating autophagy and the CDKN1B-CDK2-CCNE1-E2F1 axis, suggesting it may be a potential therapeutic target for HCC.
Article
Environmental Sciences
Xinyuan Wei, Daniel J. Hayes, Ivan Fernandez
Summary: Fires can significantly impact the flux of dissolved organic carbon (DOC) from soils, leading to an immediate decrease in riverine DOC concentration draining the watershed by 26 +/- 15%, with an average recovery time of approximately 9 months. The larger the proportion of the watershed that burned, the greater the concentration decrease and the longer the post-fire recovery period.
ENVIRONMENTAL RESEARCH LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Gabriel S. Matos, Juliana B. Madeira, Caroline Mota Fernandes, Deveney Dasilva, Claudio A. Masuda, Maurizio Del Poeta, Monica Montero-Lomeli
Summary: The SBF complex plays a crucial role in sphingolipid homeostasis regulation, influencing the transcription of key enzymes related to LCBs and ceramides synthesis during the cell cycle, with a peak at the G1/S phase. Deletion of SWI4 affects sphingolipid levels throughout the cell cycle progression and induces partial arrest at the G2/M phase.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Engineering, Environmental
Xianxian Lin, Xi Guo, Chendong Qiu, Hang Wang, Long Zheng, Zhen Zhang, Yuan Yuan, Weisheng Sun, Yiqiang Wu
Summary: The demand for advanced fire-retardant wearable materials has increased due to the rise in fire disasters. Traditional fabrics have drawbacks such as non-temperature regulation, non-recyclability, and contamination. Inspired by leaf transpiration, a flame-retardant thermal regulation material (LPWH) was developed to address these issues. LPWH demonstrates a longer ignition time, lower smoke release, and ultralow fire growth compared to commercial fire-retardant cotton fabric. It also exhibits reversible fire retardancy and great mechanical properties, making it a potential pollution-free, recyclable temperature-regulated fireproof suit.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Oncology
Yaoyao Gu, Xiaoxiao Hu, Xiaowei Liu, Cheng Cheng, Kai Chen, Yeming Wu, Zhixiang Wu
Summary: High expression of MCM6 is associated with advanced tumor stage, high risk, and poor prognosis in neuroblastoma. Inhibition of MCM6 significantly impairs neuroblastoma cell proliferation, migration, and invasion. MCM6 is considered a driver of G1/S cell cycle progression and a potential therapeutic target in neuroblastoma.
Article
Biochemistry & Molecular Biology
Diego Lastra, Maribel Escoll, Antonio Cuadrado
Summary: This study explores the involvement of transcription factor NRF2 in the cell division cycle and finds that NRF2 levels are highest during S phase entry and lowest during mitosis. NRF2 depletion leads to G1 and M arrest and affects key cell cycle regulators.
Article
Cell Biology
Jin-Yu Liu, Ya-Jing Chen, Huan-Hui Feng, Zhan-Li Chen, Yun-Long Wang, Jin-E Yang, Shi-Mei Zhuang
Summary: The study reveals that SNHG17 interacts with LRPPRC to enhance c-Myc expression, accelerate G1/S transition and cell proliferation, promoting tumor growth. High levels of SNHG17 or LRPPRC are associated with lower survival rates in HCC patients.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Jin-E Yang, Wang-Jing Zhong, Jin-Feng Li, Ying-Ying Lin, Feng-Ting Liu, Hao Tian, Ya-Jing Chen, Xiao-Yu Luo, Shi-Mei Zhuang
Summary: In this study, a novel micropeptide named SMIM30, encoded by the sORF on LINC00998, was discovered. SMIM30 was found to be localized on the membranes of the endoplasmic reticulum and mitochondria, and it played a role in promoting cell proliferation in hepatoma cells. By regulating the intracellular calcium level, SMIM30 enhanced SERCA activity and reduced cytosolic calcium level, leading to the promotion of G1/S phase transition and cell proliferation.
MOLECULAR ONCOLOGY
(2023)
Article
Biology
Robert A. Sommer, Jerry T. DeWitt, Raymond Tan, Douglas R. Kellogg
Summary: The entry into the cell cycle is initiated by the cyclin Cln3, which drives an increase in cell cycle entry by inactivating Whi5. The concentration changes of Whi5 do not play a major role in controlling the cell cycle entry process, instead, cell growth triggers the entry by increasing the concentration of Cln3. Accumulation of Cln3 is dependent upon homologs of mammalian SGK kinases, suggesting a crucial link between cell growth and the cell cycle.
Article
Engineering, Chemical
Thanh-Tin Nguyen, Rusnang Syamsul Adha, Robert W. Field, In S. Kim
Summary: The study revealed that operating at higher flux led to thicker and more compact cake layer, increasing cake structural parameter and cake layer enhanced concentration polarization. In contrast, operating at lower flux resulted in less fouling with a lower cake structural parameter.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Abayomi Babatunde Alayande, Kunli Goh, Moon Son, Chang-Min Kim, Kyu-Jung Chae, Yesol Kang, Jaewon Jang, In S. Kim, Euntae Yang
Summary: Membrane technologies are becoming more versatile and powerful with upgraded electroconductive capabilities, thanks to the development of novel materials such as carbon nanotubes and graphene. These electrically responsive membranes based on nanomaterials show promising results in mitigating membrane fouling, enhancing membrane separation performance, self-cleaning ability, and controlling membrane wettability.
Article
Chemistry, Multidisciplinary
Asta Blazyte, Abayomi Babatunde Alayande, Thanh-Tin Nguyen, Rusnang Syamsul Adha, Jaewon Jang, Mar Mar Aung, In S. Kim
Summary: The study investigated the impact of TEP pre-conditioning on the hydrophobicity and initial bacterial attachment of the FO membrane support layer. The results showed that the conditioning solution pre-treated with a 0.4 μm pore size filter contributed to the highest bacterial adhesion rates in both steady state and cross-flow mode in a lab-scale FO system for both membrane types. Additionally, the PA-TFC membrane exhibited a higher impact of fouling in cross-flow lab-scale testing compared to the CTA-ES membrane, attributed to its higher porosity and surface roughness.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Engineering, Chemical
M. Obaid, Hend Omar Mohamed, Abayomi Babatunde Alayande, Yesol Kang, Noreddine Ghaffour, In S. Kim
Summary: ENM-based filtration technology is an advanced solution for water scarcity, using gravity or low pressure to treat wastewater for reuse. Utilizing a two-step metal-phenolic network (MPN) coating process, superhydrophilic and underwater superoleophobic ENMs were developed for efficient separation of oily wastewater and oil-in-water emulsions, showing high flux values and excellent oil rejection capabilities.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Engineering, Chemical
Rusnang Syamsul Adha, Thanh-Tin Nguyen, Chulmin Lee, In S. Kim
Summary: The study investigates configurations to reduce fouling in seawater reverse osmosis systems, which can improve permeate recovery and decrease unit water cost.
Article
Engineering, Chemical
Yesol Kang, Jaewon Jang, Yunho Lee, In S. Kim
Summary: In this study, a novel thin-film composite loose nanofiltration membrane was successfully fabricated with the addition of magnetite-decorated graphene oxide particles to improve salt permeation and dye rejection, while also providing excellent anti-fouling properties. This method shows great potential for the development of innovative saline wastewater treatment membranes.
Article
Engineering, Chemical
Chulmin Lee, In S. Kim
Summary: This study experimentally investigated the variation of osmotic membrane performance under different compression ratios and found that the performance of commercial osmotic membrane did not significantly decrease at 30-40% compression ratio, with potential savings in module packing density. The findings and methods will facilitate the structural optimization of ODMP membrane modules.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Engineering, Chemical
Hasan Fareed, Ghulam Hussain Qasim, Jaewon Jang, Woojin Lee, Seunghee Han, In S. Kim
Summary: In this study, the PV performance of PAN-based mixed matrix membranes was improved by adding kaolin, resulting in increased hydrophilicity and water sorption capacity. The addition of 2% kaolin enhanced membrane properties and led to outstanding permeation fluxes and salt rejection rates under different salt concentrations.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chang Woo Chae, Gee Euhn Choi, Young Hyun Jung, Jae Ryong Lim, Ji Hyeon Cho, Jee Hyeon Yoon, Ho Jae Han
Summary: The study investigates the relationship between hyperglycemia-induced retromer dysfunction and Alzheimer's disease (AD). The researchers found that high glucose down-regulated the vacuolar protein sorting-associated protein 26a (VPS26a) through a methylation pathway, leading to impaired intracellular trafficking and increased AD-like pathology. Restoring VPS26a levels improved cellular transport and decreased levels of amyloid beta (A beta) and phosphorylated tau (p-tau), suggesting that VPS26a plays a role in inhibiting DM-associated AD pathogenesis.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gee Euhn Choi, Chang Woo Chae, Mo Ran Park, Jee Hyeon Yoon, Young Hyun Jung, Hyun Jik Lee, Ho Jae Han
Summary: Exposure to prenatal stress has irreversible effects on neurogenesis and can lead to cognitive and neuropsychiatric abnormalities in adulthood. This study identified glucocorticoid as a key factor impairing neurogenesis and inducing abnormal behaviors. The researchers also discovered that astrocytes derived from neural stem cells exhibited neurotoxic properties after glucocorticoid treatment. Additionally, the study revealed that cortisol-treated astrocytic conditioned media inhibited glutamatergic synaptic formation and transmission in differentiating neurons. Restoring the expression of neuroligin 1 and neuronal FGFR1 through FGF2 treatment improved glutamatergic synaptogenesis and overall neurogenesis. The findings highlight the importance of understanding the impact of prenatal stress on brain development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Engineering, Environmental
Jaewon Jang, Yesol Kang, Kyunghoon Jang, Suhun Kim, Sang-Soo Chee, In S. Kim
Summary: In a situation of generating large amounts of industrial wastewater worldwide, developing efficient technology to remove various types of heavy metal ions from wastewater is crucial. This study demonstrates the use of a functionalized Ti3C2TX-EDA membrane as the active layer of a nanofiltration membrane, which shows excellent rejection against six types of heavy metal ions and exhibits high pure water permeance and continuous nanofiltration performance.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Chemical
Jaewon Jang, Yesol Kang, Kihyeun Kim, Suhun Kim, Myungwoo Son, Sang-Soo Chee, In S. Kim
Summary: In the face of limitations in previous renewable energy systems, salinity gradient power (SGP) can be a new alternative that is not affected by climate and time. This study proposes a cation exchange membrane (CEM) with engineering nanostructure and introduces a new material for the reverse electrodialysis (RED) system. The Nafion@MXene/Cellulose acetate (CA) composite CEM shows superior physical/electrochemical properties and higher power density in the RED system than other membranes.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Hobin Jee, Jaewon Jang, Yesol Kang, Tasnim Eisa, Kyu-Jung Chae, In S. Kim, Euntae Yang
Summary: In this study, the use of divalent cation crosslinking was attempted to improve the resistance against swelling in partially reduced GO membranes. It was found that the crosslinked membranes demonstrated improved dye rejection efficiency and mechanical stability.
Article
Engineering, Chemical
Thanh-Tin Nguyen, Kyunghoon Jang, Namguk Her, Chang Seong Kim, Soo Wan Kim, In S. Kim
Summary: Developing a hemodialysis membrane that effectively removes both small-sized toxins and middle molecules is vital. This study successfully fabricated novel hemodialysis membranes with different inner diameters, demonstrating superior removal efficiency for both small molecules and middle molecules. The spinning conditions had a significant impact on the membrane properties, affecting the clearance of uremic toxins and protein loss/leaking. Overall, the study proposes a promising membrane for hemodialysis application that achieves increased removal of middle molecules while minimizing protein loss and leakage.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Cell Biology
Min Jeong Kim, Gee Euhn Choi, Chang Woo Chae, Jae Ryong Lim, Young Hyun Jung, Jee Hyeon Yoon, Ji Yong Park, Ho Jae Han
Summary: Carrots can decrease the likelihood of rabbits developing nearsightedness.
CELL DEATH & DISEASE
(2023)
