Discovery of 5-(2-(Phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one Derivatives as Potent Mnk2 Inhibitors: Synthesis, SAR Analysis and Biological Evaluation
出版年份 2014 全文链接
标题
Discovery of 5-(2-(Phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one Derivatives as Potent Mnk2 Inhibitors: Synthesis, SAR Analysis and Biological Evaluation
作者
关键词
-
出版物
ChemMedChem
Volume 9, Issue 5, Pages 962-972
出版商
Wiley
发表日期
2014-02-12
DOI
10.1002/cmdc.201300552
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Targeting Mnks for Cancer Therapy
- (2015) Jinqiang Hou et al. Oncotarget
- Inhibition of S6 kinase suppresses the apoptotic effect of eIF4E ablation by inducing TGF-β-dependent G1 cell cycle arrest
- (2013) Paige Yellen et al. CANCER LETTERS
- Rational Design of Resorcylic Acid Lactone Analogues as Covalent MNK1/2 Kinase Inhibitors by Tuning the Reactivity of an Enamide Michael Acceptor
- (2013) Jin Xu et al. ChemMedChem
- Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure–Activity Relationship, and Anticancer Activities
- (2013) Hao Shao et al. JOURNAL OF MEDICINAL CHEMISTRY
- Insights into the Importance of DFD-Motif and Insertion I1 in Stabilizing the DFD-Out Conformation of Mnk2 Kinase
- (2013) Jinqiang Hou et al. ACS Medicinal Chemistry Letters
- Pharmacological targeting of eIF4E in primary CLL lymphocytes
- (2013) V Martinez-Marignac et al. Blood Cancer Journal
- Comparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity
- (2012) Alison J. Hole et al. JOURNAL OF MEDICINAL CHEMISTRY
- Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases
- (2011) B. W. Konicek et al. CANCER RESEARCH
- The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival
- (2010) Matthew J. Wheater et al. CANCER BIOLOGY & THERAPY
- In Vivo Efficacy of Natural Product-Inspired Irreversible Kinase Inhibitors
- (2010) Sofia Barluenga et al. CHEMBIOCHEM
- Discovery and Characterization of 2-Anilino-4- (Thiazol-5-yl)Pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents
- (2010) Shudong Wang et al. CHEMISTRY & BIOLOGY
- Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development
- (2010) T. Ueda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression
- (2010) L. Furic et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synthesis of a Resorcylic Acid Lactone (RAL) Library Using Fluorous-Mixture Synthesis and Profile of its Selectivity Against a Panel of Kinases
- (2009) Rajamalleswaramma Jogireddy et al. CHEMISTRY-A EUROPEAN JOURNAL
- Inhibition of Polysome Assembly Enhances Imatinib Activity against Chronic Myelogenous Leukemia and Overcomes Imatinib Resistance
- (2008) M. Zhang et al. MOLECULAR AND CELLULAR BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More