Development of Second-Generation Small-Molecule RhoA Inhibitors with Enhanced Water Solubility, Tissue Potency, and Significant in vivo Efficacy

The Antithrombotic Effects of Statins

(2014) A. Phillip Owens et al.   Annual Review of Medicine

Regulation of RhoA Activity by Adhesion Molecules and Mechanotransduction

(2014) R.J. Marjoram et al.   CURRENT MOLECULAR MEDICINE

Correlation of the Rac1/RhoA Pathway With Ezrin Expression in Osteosarcoma

(2014) Caterina Chiappetta et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Emerging targets for novel therapy of asthma

(2013) William T Gerthoffer et al.   CURRENT OPINION IN PHARMACOLOGY

Advances in the studies of roles of Rho/Rho-kinase in diseases and the development of its inhibitors

(2013) Ronggui Guan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility

(2013) Bassem D. Khalil et al.   EXPERIMENTAL CELL RESEARCH

Regulation on RhoA in Vascular Smooth Muscle Cells Under Inflammatory Stimulation Proposes a Novel Mechanism Mediating the Multiple-Beneficial Action of Acetylsalicylic Acid

(2013) Dong-Bo Li et al.   INFLAMMATION

Long-term administration of rosuvastatin prevents contractile and electrical remodelling of diabetic rat heart

(2013) Nihal Ozturk et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Rho Kinases in Cardiovascular Physiology and Pathophysiology

(2013) Jianjian Shi et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors

(2013) Xuan Zhou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased level of p63RhoGEF and RhoA/Rho kinase activity in hypertensive patients

(2013) Lorenzo A. Calò et al.   JOURNAL OF HYPERTENSION

Synthesis and Biological Evaluation of Urea Derivatives as Highly Potent and Selective Rho Kinase Inhibitors

(2013) Yan Yin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cerebral Vasospasm and Delayed Cerebral Ischemia in Intraventricular Hemorrhage

(2013) J. U. Regula et al.   Neurocritical Care

Controversies and evolving new mechanisms in subarachnoid hemorrhage

(2013) Sheng Chen et al.   PROGRESS IN NEUROBIOLOGY

ROCK1 feedback regulation of the upstream small GTPase RhoA

(2012) Alan T. Tang et al.   CELLULAR SIGNALLING

The Effect of First-in-Class Small Molecule RhoA Inhibitor, HL07, on the Phenylephrine-induced Artery Contraction

(2012) Yan Zhang et al.   CURRENT PHARMACEUTICAL DESIGN

Tonic arterial contraction mediated by L-type Ca2+ channels requires sustained Ca2+ influx, G protein-associated Ca2+ release, and RhoA/ROCK activation

(2012) Miguel Fernández-Tenorio et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nuanced junctional RhoA activity

(2012) Swapnil S. Kher et al.   NATURE CELL BIOLOGY

Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry

(2011) Minoru Ishikawa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Synthesis of Small Molecule RhoA Inhibitors: A New Promising Therapy for Cardiovascular Diseases?

(2011) Jing Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease

(2011) Qian Zhou et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Statins: A Potential Therapeutic Addition to Treatment for Aneurysmal Subarachnoid Hemorrhage?

(2010) Mohammed Sabri et al.   World Neurosurgery

Signaling Through Rho GTPase Pathway as Viable Drug Target

(2009) Qun Lu et al.   CURRENT MEDICINAL CHEMISTRY

Interleukin-4 upregulates RhoA protein via an activation of STAT6 in cultured human bronchial smooth muscle cells

(2009) Yoshihiko Chiba et al.   PHARMACOLOGICAL RESEARCH

Crystal structure of theClostridium limosumC3 exoenzyme

(2008) Martin Vogelsgesang et al.   FEBS LETTERS

Local Inhibition of Rho Signaling by Cell-Permeable Recombinant Protein BA-210 Prevents Secondary Damage and Promotes Functional Recovery following Acute Spinal Cord Injury

(2008) Stephanie Lord-Fontaine et al.   JOURNAL OF NEUROTRAUMA