The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile-Part 2

Novel Spiroketal Pyrrolidine GSK2336805 Potently Inhibits Key Hepatitis C Virus Genotype 1b Mutants: From Lead to Clinical Compound

(2014) Wieslaw M. Kazmierski et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hepatitis C Virus NS5A Replication Complex Inhibitors. Part 6: Discovery of a Novel and Highly Potent Biarylimidazole Chemotype with Inhibitory Activity Toward Genotypes 1a and 1b Replicons

(2014) Makonen Belema et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Development of Hepatitis C Virus NS5A Replication Complex Inhibitors

(2014) Makonen Belema et al.   JOURNAL OF MEDICINAL CHEMISTRY

HCV NS5A Replication Complex Inhibitors. Part 4.1 Optimization for Genotype 1a Replicon Inhibitory Activity

(2013) Denis R. St. Laurent et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterizations of HCV NS5A replication complex inhibitors

(2013) Donald R. O'Boyle II et al.   VIROLOGY

Direct-Acting Antiviral Agents for Hepatitis C Virus Infection

(2012) Jennifer J. Kiser et al.   Annual Review of Pharmacology and Toxicology

Synthesis and evaluation of novel potent HCV NS5A inhibitors

(2012) Hongwang Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics

(2012) Wonsuk Chang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors

(2012) Junxing Shi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of Potent Hepatitis C Virus NS5A Inhibitors with Dimeric Structures

(2011) Julie A. Lemm et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Development of a new permeability assay using low‐efflux MDCKII cells

(2011) Li Di et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space

(2011) Alexander Alex et al.   MedChemComm

Intramolecular Hydrogen Bonding in Medicinal Chemistry

(2010) Bernd Kuhn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Medium-Bridged Twisted Lactams via Cation−π Control of the Regiochemistry of the Intramolecular Schmidt Reaction

(2010) Michal Szostak et al.   JOURNAL OF ORGANIC CHEMISTRY

Oligooxopiperazines as Nonpeptidic α-Helix Mimetics

(2010) Petra Tošovská et al.   ORGANIC LETTERS

Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus

(2009) R. A. Love et al.   JOURNAL OF VIROLOGY

The global burden of hepatitis C

(2009) Daniel Lavanchy   LIVER INTERNATIONAL

Pre-clinical pharmacokinetics of UK-453,061, a novel non-nucleoside reverse transcriptase inhibitor (NNRTI), and use ofin silicophysiologically based prediction tools to predict the oral pharmacokinetics of UK-453,061 in man

(2008) G. Allan et al.   XENOBIOTICA