Discovery of MK-8742: An HCV NS5A Inhibitor with Broad Genotype Activity

Targeting the NS5A protein of HCV: An emerging option

(2014) D.G. Cordek et al.   DRUGS OF THE FUTURE

NS5A inhibitors in the treatment of hepatitis C

(2013) Jean-Michel Pawlotsky   JOURNAL OF HEPATOLOGY

Understanding the hepatitis C virus life cycle paves the way for highly effective therapies

(2013) Troels K H Scheel et al.   NATURE MEDICINE

Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life

(2013) J. Guedj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HCV NS5A Inhibitors in Development

(2012) Anna Suk-Fong Lok   Clinics in Liver Disease

A phase 1, randomized, placebo-controlled, 3-day, dose-ranging study of GS-5885, an NS5A inhibitor, in patients with genotype 1 hepatitis C

(2012) Eric J. Lawitz et al.   JOURNAL OF HEPATOLOGY

Small molecule inhibitors of the hepatitis C virus-encoded NS5A protein

(2012) Oscar Belda et al.   VIRUS RESEARCH

Discovery of Potent Hepatitis C Virus NS5A Inhibitors with Dimeric Structures

(2011) Julie A. Lemm et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multiple ascending dose study of BMS-790052, a nonstructural protein 5A replication complex inhibitor, in patients infected with hepatitis C virus genotype 1

(2011) Richard E. Nettles et al.   HEPATOLOGY

Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes

(2011) Jeffrey L. Romine et al.   ACS Medicinal Chemistry Letters

Evolving epidemiology of hepatitis C virus

(2010) D. Lavanchy   CLINICAL MICROBIOLOGY AND INFECTION

Recombinant HCV Variants With NS5A From Genotypes 1–7 Have Different Sensitivities to an NS5A Inhibitor but Not Interferon-α

(2010) Troels K.H. Scheel et al.   GASTROENTEROLOGY

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

(2010) Min Gao et al.   NATURE

MK-7009, a Potent and Selective Inhibitor of Hepatitis C Virus NS3/4A Protease

(2009) N. J. Liverton et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and SAR of piperazinyl-N-phenylbenzamides as inhibitors of hepatitis C virus RNA replication in cell culture

(2009) Immacolata Conte et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of Hepatitis C Virus NS5A Inhibitors

(2009) J. A. Lemm et al.   JOURNAL OF VIROLOGY

Robust Antiviral Efficacy upon Administration of a Nucleoside Analog to Hepatitis C Virus-Infected Chimpanzees

(2008) S. S. Carroll et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A transient cell-based phenotype assay for hepatitis C NS3/4A protease: Application to potency determinations of a novel macrocyclic inhibitor against diverse protease sequences isolated from plasma infected with HCV

(2008) Steven W. Ludmerer et al.   JOURNAL OF VIROLOGICAL METHODS