Design and Generation of Highly Diverse Fluorinated Fragment Libraries and their Efficient Screening with Improved19F NMR Methodology

Carboxylic Acid (Bio)Isosteres in Drug Design

(2013) Carlo Ballatore et al.   ChemMedChem

Application of the rule of shielding in the design of novel fluorinated structural motifs and peptidomimetics

(2013) Claudio Dalvit et al.   JOURNAL OF FLUORINE CHEMISTRY

Synthesis of Fluorinated β-Aminophosphonates and γ-Lactams

(2013) Concepción Alonso et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of fluorinated maltose derivatives for monitoring protein interaction by19F NMR

(2012) Michaela Braitsch et al.   Beilstein Journal of Organic Chemistry

Trifluoromethanesulfonamides and Related Compounds

(2012) Bagrat A. Shainyan et al.   CHEMICAL REVIEWS

Intermolecular and Intramolecular Hydrogen Bonds Involving Fluorine Atoms: Implications for Recognition, Selectivity, and Chemical Properties

(2012) Claudio Dalvit et al.   ChemMedChem

Fluorine local environment: from screening to drug design

(2012) Anna Vulpetti et al.   DRUG DISCOVERY TODAY

Nuclear Magnetic Resonance of Hyperpolarized Fluorine for Characterization of Protein–Ligand Interactions

(2012) Youngbok Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Technical and practical aspects of 19F NMR-based screening: toward sensitive high-throughput screening with rapid deconvolution

(2012) Claudio Dalvit et al.   MAGNETIC RESONANCE IN CHEMISTRY

Fragment Based Drug Discovery: Practical Implementation Based on 19F NMR Spectroscopy

(2011) John B. Jordan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rapid acquisition of 1H and 19F NMR experiments for direct and competition ligand-based screening

(2011) Claudio Dalvit et al.   MAGNETIC RESONANCE IN CHEMISTRY

ChEMBL: a large-scale bioactivity database for drug discovery

(2011) A. Gaulton et al.   NUCLEIC ACIDS RESEARCH

Simultaneous 19F NMR Screening of Prolyl Oligopeptidase and Dipeptidyl Peptidase IV Inhibitors

(2010) Nessim Kichik et al.   CHEMBIOCHEM

Fluorine-Protein Interactions and 19F NMR Isotropic Chemical Shifts: An Empirical Correlation with Implications for Drug Design

(2010) Claudio Dalvit et al.   ChemMedChem

19F NMR chemical shift prediction with fluorine fingerprint descriptor

(2010) Anna Vulpetti et al.   JOURNAL OF FLUORINE CHEMISTRY

Fluorine in health care: Organofluorine containing blockbuster drugs

(2010) David O’Hagan   JOURNAL OF FLUORINE CHEMISTRY

Combined use of computational chemistry, NMR screening, and X-ray crystallography for identification and characterization of fluorophilic protein environments

(2010) Anna Vulpetti et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

NMR methods in fragment screening: theory and a comparison with other biophysical techniques

(2009) Claudio Dalvit   DRUG DISCOVERY TODAY

Preparation of Pentafluorosulfanyl (SF5) Pyrrole Carboxylic Acid Esters

(2009) William R. Dolbier et al.   JOURNAL OF ORGANIC CHEMISTRY

Design and NMR-Based Screening of LEF, a Library of Chemical Fragments with Different Local Environment of Fluorine

(2009) Anna Vulpetti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and synthesis of a series of meta aniline-based LFA-1 ICAM inhibitors

(2008) Kevin M. Guckian et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pentafluorosulfanyl as a Novel Building Block for Enzyme Inhibitors: Trypanothione Reductase Inhibition and Antiprotozoal Activities of Diarylamines

(2008) Bernhard Stump et al.   CHEMBIOCHEM

Theoretical analysis of the competition ligand-based NMR experiments and selected applications to fragment screening and binding constant measurements

(2008) Claudio Dalvit   CONCEPTS IN MAGNETIC RESONANCE PART A

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS