2-Aminothiazoles with Improved Pharmacotherapeutic Properties for Treatment of Prion Disease

A Unifying Role for Prions in Neurodegenerative Diseases

(2012) S. B. Prusiner   SCIENCE

Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders

(2011) Mathias Jucker et al.   ANNALS OF NEUROLOGY

Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity

(2011) Mark J. Thompson et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2-Aminothiazoles as Therapeutic Leads for Prion Diseases

(2011) Alejandra Gallardo-Godoy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Predicting Binding to P-Glycoprotein by Flexible Receptor Docking

(2011) Elena Dolghih et al.   PLoS Computational Biology

Getting a Grip on Prions: Oligomers, Amyloids, and Pathological Membrane Interactions

(2009) Byron Caughey et al.   Annual Review of Biochemistry

Discovery of 2-Aminothiazoles as Potent Antiprion Compounds

(2009) S. Ghaemmaghami et al.   JOURNAL OF VIROLOGY

Molecular Mechanisms of Prion Pathogenesis

(2008) Adriano Aguzzi et al.   Annual Review of Pathology-Mechanisms of Disease

Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions

(2008) James Shorter et al.   EMBO JOURNAL