From a Multipotent Stilbene to Soluble Epoxide Hydrolase Inhibitors with Antiproliferative Properties

Nematode-Bacterium Symbioses—Cooperation and Conflict Revealed in the “Omics” Age

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A Natural Product Inspired Tetrahydropyran Collection Yields Mitosis Modulators that Synergistically Target CSE1L and Tubulin

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Impact of Soluble Epoxide Hydrolase and Epoxyeicosanoids on Human Health

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The therapeutic journey of benzimidazoles: A review

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Chemical genetic discovery of targets and anti-targets for cancer polypharmacology

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Small molecule perimeter defense in entomopathogenic bacteria

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Dual-Target Virtual Screening by Pharmacophore Elucidation and Molecular Shape Filtering

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Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies

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Biology-Oriented Synthesis

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Aromatic Rings in Chemical and Biological Recognition: Energetics and Structures

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Sorafenib attenuates p21 in kidney cancer cells and augments cell death in combination with DNA-damaging chemotherapy

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Complementary Screening Techniques Yielded Fragments that Inhibit the Phosphatase Activity of Soluble Epoxide Hydrolase

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Epoxyeicosatrienoic acids: a double-edged sword in cardiovascular diseases and cancer

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Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice

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Discovery of Inhibitors of Soluble Epoxide Hydrolase: A Target with Multiple Potential Therapeutic Indications

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The epoxyeicosatrienoic acid-stimulated phosphorylation of EGF-R involves the activation of metalloproteinases and the release of HB-EGF in cancer cells

(2010) Li-ming Cheng et al.   ACTA PHARMACOLOGICA SINICA

Inhibition of the Soluble Epoxide Hydrolase Promotes Albuminuria in Mice with Progressive Renal Disease

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Photorhabdusand a Host of Hosts

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Entomopathogenic bacteria as a source of secondary metabolites

(2009) Helge B Bode   CURRENT OPINION IN CHEMICAL BIOLOGY

The topology of drug–target interaction networks: implicit dependence on drug properties and target families

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Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo

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Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases

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Bacterial Biosynthesis of a Multipotent Stilbene

(2008) Susan A. Joyce et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Opposite Regulation of Cholesterol Levels by the Phosphatase and Hydrolase Domains of Soluble Epoxide Hydrolase

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A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology