Selective Bisubstrate Inhibitors with Sub-nanomolar Affinity for Protein Kinase Pim-1

Time-gated luminescence assay using nonmetal probes for determination of protein kinase activity-based disease markers

(2012) Marje Kasari et al.   ANALYTICAL BIOCHEMISTRY

Pim kinases in cancer: Diagnostic, prognostic and treatment opportunities

(2012) Carmen Blanco-Aparicio et al.   BIOCHEMICAL PHARMACOLOGY

Conjugates of 5-isoquinolinesulfonylamides and oligo-d-arginine possess high affinity and selectivity towards Rho kinase (ROCK)

(2012) Darja Lavogina et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Time-gated luminescence microscopy with responsive nonmetal probes for mapping activity of protein kinases in living cells

(2012) Angela Vaasa et al.   CHEMICAL COMMUNICATIONS

Insights from Pim1 structure for anti-cancer drug design

(2012) Naoko Ogawa et al.   Expert Opinion on Drug Discovery

Potential Use of Selective and Nonselective Pim Kinase Inhibitors for Cancer Therapy

(2012) Denis Drygin et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel Pim-1 Kinase Inhibitor Targeting Residues That Bind the Substrate Peptide

(2012) Keiko Tsuganezawa et al.   JOURNAL OF MOLECULAR BIOLOGY

A subnanomolar fluorescent probe for protein kinase CK2 interaction studies

(2012) Erki Enkvist et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Protein-Induced Long Lifetime Luminescence of Nonmetal Probes

(2011) Erki Enkvist et al.   ACS Chemical Biology

Design and Characterization of a Potent and Selective Dual ATP- and Substrate-Competitive Subnanomolar Bidentate c-Jun N-Terminal Kinase (JNK) Inhibitor

(2011) John L. Stebbins et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small-molecule FRET probes for protein kinase activity monitoring in living cells

(2010) Angela Vaasa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HIV-1 Tat-peptide inhibits protein kinase C and protein kinase A through substrate competition

(2010) Elina Ekokoski et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Pim kinase inhibitors: a survey of the patent literature

(2010) Tina Morwick   EXPERT OPINION ON THERAPEUTIC PATENTS

Why target PIM1 for cancer diagnosis and treatment?

(2010) Nancy S Magnuson et al.   Future Oncology

PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers

(2010) L. Brault et al.   HAEMATOLOGICA

Cell-permeable Carboxyl-terminal p27Kip1Peptide Exhibits Anti-tumor Activity by Inhibiting Pim-1 Kinase

(2010) Daisuke Morishita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diversity of Bisubstrate Binding Modes of Adenosine Analogue–Oligoarginine Conjugates in Protein Kinase A and Implications for Protein Substrate Interactions

(2010) Alexander Pflug et al.   JOURNAL OF MOLECULAR BIOLOGY

Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells

(2009) L. S. Chen et al.   BLOOD

Bisubstrate Inhibitors of Protein Kinases: from Principle to Practical Applications

(2009) Darja Lavogina et al.   ChemMedChem

Discovery of 3H-Benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective, and Orally Bioavailable Inhibitors of the Human Protooncogene Proviral Insertion Site in Moloney Murine Leukemia Virus (PIM) Kinases

(2009) Zhi-Fu Tao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Analysis of ARC-Type Inhibitor (ARC-1034) Binding to Protein Kinase A Catalytic Subunit and Rational Design of Bisubstrate Analogue Inhibitors of Basophilic Protein Kinases

(2008) Darja Lavogina et al.   JOURNAL OF MEDICINAL CHEMISTRY