Discovery of Depsides and Depsidones from Lichen as Potent Inhibitors of Microsomal Prostaglandin E2 Synthase-1 Using Pharmacophore Models

Identification and development of mPGES-1 inhibitors: where we are at?

(2011) Hui-Hua Chang et al.   Future Medicinal Chemistry

Discovery and Biological Evaluation of a Novel Class of Dual Microsomal Prostaglandin E2Synthase-1/5-lipoxygenase Inhibitors Based on 2-[(4,6-Diphenethoxypyrimidin-2-yl)thio]hexanoic Acid

(2011) Martina Hieke et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacophore Modeling and Virtual Screening for Novel Acidic Inhibitors of Microsomal Prostaglandin E2Synthase-1 (mPGES-1)

(2011) Birgit Waltenberger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo

(2010) Julia Bauer et al.   BIOCHEMICAL PHARMACOLOGY

Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models

(2010) Shuntaro Hara et al.   BIOCHIMIE

Inhibition of microsomal prostaglandin E2 synthase-1 as a molecular basis for the anti-inflammatory actions of boswellic acids from frankincense

(2010) U Siemoneit et al.   BRITISH JOURNAL OF PHARMACOLOGY

Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1

(2010) Sven-Christian Pawelzik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Computer-Aided Discovery, Validation, and Mechanistic Characterization of Novel Neolignan Activators of Peroxisome Proliferator-Activated Receptor  

(2010) N. Fakhrudin et al.   MOLECULAR PHARMACOLOGY

Pharmacological properties of lichenCladonia clathrata

(2010) José Alexandre da Costa Silva et al.   PHARMACEUTICAL BIOLOGY

Green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin E 2 synthase-1

(2009) Andreas Koeberle et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol

(2009) Andreas Koeberle et al.   BIOCHEMICAL PHARMACOLOGY

Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E2 synthase-1

(2009) A Koeberle et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nonsteroidal Anti-Inflammatory Drugs: A Critical Review on Current Concepts Applied to Reduce Gastrointestinal Toxicity

(2009) Mona Abdel-Tawab et al.   CURRENT MEDICINAL CHEMISTRY

Inhibitors of the Microsomal Prostaglandin E2 Synthase-1 as Alternative to Non Steroidal Anti-Inflammatory Drugs (NSAIDs) – A Critical Review

(2009) A. Koeberle et al.   CURRENT MEDICINAL CHEMISTRY

Biologically active components of a Papua New Guinea analgesic and anti-inflammatory lichen preparation

(2009) Tim S. Bugni et al.   FITOTERAPIA

Nonacidic Inhibitors of Human Microsomal Prostaglandin Synthase 1 (mPGES 1) Identified by a Multistep Virtual Screening Protocol

(2009) Florian Rörsch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cytotoxic Constituents of the LichenDiploicia canescens

(2009) Marion Millot et al.   JOURNAL OF NATURAL PRODUCTS

Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1

(2009) A. Koeberle et al.   MOLECULAR CANCER THERAPEUTICS

In vitro and in vivo immunomodulating effects of traditionally prepared extract and purified compounds from Cetraria islandica

(2008) J. Freysdottir et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1

(2008) A. Koeberle et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Structural basis for induced formation of the inflammatory mediator prostaglandin E2

(2008) C. Jegerschold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA