Review
Oncology
Jing Xu, Bo Cao, Chunyu Li, Guohui Li
Summary: Breast cancer is a global health concern. Endocrine therapy is crucial in treating estrogen-positive breast cancer, but it often leads to osteoporosis-related adverse events. These events increase the risk of fractures and reduce the patients' quality of life. This review explores the possibility of endocrine therapy-induced osteoporosis in estrogen-positive breast cancer treatment and discusses the mechanisms involved and the potential of drug therapies and combinations.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Elizabeth Joyce, Grant Carr, Sidi Wang, Chad M. Brummett, Kelley M. Kidwell, N. Lynn Henry
Summary: This study found that the presence of nociplastic pain prior to surgery was associated with premature discontinuation of endocrine therapy. Fibromyalgia Score screening may be a useful tool for evaluating the risk of therapy discontinuation. Treatments targeting nociplastic pain may be more effective for treating therapy-emergent pain.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Review
Oncology
Inga Bekes, Jens Huober
Summary: Seventy percent of breast cancer subtypes are hormone receptor-positive, and adjuvant endocrine therapy is crucial for these patients. Extending adjuvant endocrine therapy beyond 5 years has been shown to reduce the risk of late recurrence, but the optimal duration is still debated. Newer data suggest only marginal benefits beyond 7 to 10 years, and longer duration may result in more side effects. Therefore, it is important to select patients who qualify for extended therapy based on genomic tests and risk assessment.
Article
Oncology
Takuji Iwase, Shigehira Saji, Kotaro Iijima, Kenji Higaki, Shoichiro Ohtani, Yasuyuki Sato, Yasuo Hozumi, Yoshie Hasegawa, Yasuhiro Yanagita, Hiroyuki Takei, Maki Tanaka, Hideji Masuoka, Masahiko Tanabe, Chiyomi Egawa, Yoshifumi Komoike, Toshitaka Nakamura, Hiroshi Ohtsu, Hirofumi Mukai
Summary: This study investigated the effects of extending the treatment with an aromatase inhibitor for 10 years on disease-free survival in postmenopausal hormone receptor-positive breast cancer patients. The results showed that extending the treatment with an aromatase inhibitor for an additional 5 years improved disease-free survival.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Niklas Gremke, Sebastian Griewing, Arturas Kadys, Karel Kostev, Uwe Wagner, Matthias Kalder
Summary: Endocrine therapy is the primary systemic treatment for hormone receptor positive breast cancer, but it can lead to side effects such as bone loss. This study aimed to investigate the prescription of antiresorptive drugs in breast cancer patients undergoing endocrine therapy in Germany and found that patients on aromatase inhibitors were more likely to receive antiresorptive drugs, particularly denosumab.
Article
Cell Biology
Nahla M. Badr, David Spooner, Jane Steven, Andrea Stevens, Abeer M. Shaaban
Summary: This study investigated the effect of NAET on tumour type, grade, and molecular profile in breast cancer patients. Significant changes were observed, including complete pathological response in some cases, central scarring in almost half of the tumours post-treatment, and downgrading of tumour grade in one-third of cases. The study suggests a histological method for assessing residual carcinoma after NAET and recommends repeat ER/PR/HER2 testing for management and prognosis.
Article
Chemistry, Inorganic & Nuclear
Xiao-Meng Liu, Zhe Li, Xin-Rui He, Rui-Ping Liu, Zhong-Ying Ma, Xin Qiao, Shu-Qing Wang, Jing-Yuan Xu
Summary: The study designed and prepared a new class of multi-targeting Pt(IV) prodrugs using the FDA-approved aromatase inhibitor aminoglutethimide, with a representative compound aminoplatin 3 showing enhanced anticancer activity and lower toxicity compared to cisplatin in ER-positive MCF-7 cells.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Oncology
Eileen Rillamas-Sun, Marilyn L. Kwan, Carlos Iribarren, Richard Cheng, Romain Neugebauer, Jamal S. Rana, Mai Nguyen-Huynh, Zaixing Shi, Cecile A. Laurent, Valerie S. Lee, Janise M. Roh, Yuhan Huang, Hanjie Shen, Dawn L. Hershman, Lawrence H. Kushi, Heather Greenlee
Summary: This study investigated the effects of endocrine therapy on cardiovascular disease risk factors in hormone receptor-positive breast cancer survivors. The results suggest that survivors treated with AIs may have a higher risk of developing diabetes, dyslipidemia, and hypertension compared to those not using endocrine therapy.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Review
Oncology
Li Huifang, Gao Jie, Feng Yi
Summary: Aromatase inhibitors are the most commonly used endocrine therapy for breast cancer patients, but they often cause adverse reactions such as muscle and joint pain, fatigue, anxiety, depression, and sleep disturbances. The rapid decline of hormones leads to inflammation and bone loss. Therefore, studying poor adherence from the perspective of neuro-immuno-endocrine is of great significance for clinical intervention.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Maurice J. Berkowitz, Carlie K. Thompson, Laura T. Zibecchi, Minna K. Lee, Elani Streja, Jacob S. Berkowitz, Cachet M. Wenziger, Jennifer L. Baker, Maggie L. DiNome, Deanna J. Attai
Summary: The survey revealed that many HR+ breast cancer patients experience side effects during ET, with about one-third discontinuing treatment prematurely. While most felt supported by their medical team, 31.5% reported that their side effects were dismissed or minimized.
JOURNAL OF CANCER SURVIVORSHIP
(2021)
Article
Cell Biology
Fahmida Rasha, Monica Sharma, Kevin Pruitt
Summary: The most common subtype of BC is characterized by ER expression, with treatment typically involving suppression of estrogen production or hindering estrogen binding to its receptors. Despite the benefits of endocrine therapy, overcoming resistance driven by complex changes in the tumor microenvironment remains a clinical challenge, highlighting the need for further investigation into ER modulation mechanisms.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Oncology
S. N. Aleksakhina, M. M. Kramchaninov, A. D. Mikushina, S. E. Kubrina, V. V. Petkau, A. O. Ivantsov, V. M. Moiseyenko, E. N. Imyanitov, A. G. Iyevleva
Summary: The presence of CCND1 and/or FGFR1 amplification is associated with worse outcomes of AI therapy in patients with metastatic BC.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Nursing
So-Hyun Park, Shiela M. Strauss
Summary: Female breast cancer survivors taking adjuvant endocrine therapy are more likely to have oral health issues compared to those not taking such therapy, emphasizing the need for improved awareness and management guidelines.
AMERICAN JOURNAL OF NURSING
(2023)
Review
Biochemistry & Molecular Biology
Fulvio Borella, Stefano Fucina, Luca Mangherini, Stefano Cosma, Andrea Roberto Carosso, Jessica Cusato, Paola Cassoni, Luca Bertero, Dionyssios Katsaros, Chiara Benedetto
Summary: Epithelial ovarian cancer (EOC) is a leading cause of cancer-related death in women, and its treatment remains challenging with poor survival rates. While the role of hormone receptors (HRs) in EOC has been actively explored, the use of hormone therapy (HT) in treating these tumors is still not well-established. Available data mostly come from retrospective series and small early clinical trials, suggesting that HT may be beneficial in adjuvant therapy, maintenance therapy, or in cases of recurrent disease, particularly for certain subtypes of EOC.
Editorial Material
Oncology
Johanna E. Poterala, Kari B. Wisinski
Summary: A shorter course of endocrine therapy may be reasonable for breast cancer patients with low estrogen receptor expression, but further validation is needed.
Article
Chemistry, Inorganic & Nuclear
Rex S. C. Charman, Mary F. Mahon, John P. Lowe, David J. Liptrot
Summary: Three ring-expanded N-heterocyclic carbene-supported copper(I) triphenylstannyls were synthesized and characterized. Reactions with various substrates yielded copper(I) benzamidinate, benzamide and benzothiamide via phenyl transfer from the triphenylstannyl anion. However, attempts to utilize this reactivity under a catalytic regime were hindered by rapid copper(I)-catalyzed dismutation reactions.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Timothy A. Ablott, Rhian Webby, Daniel R. Jenkinson, Alexandra Nikolich, Lujia Liu, Harina Amer Hamzah, Mary F. Mahon, Andrew D. Burrows, Christopher Richardson
Summary: Here, we report coupling in situ high temperature postsynthetic modifications (PSMs) in metal-organic frameworks (MOFs). Thermo-reactive propargyloxy-functionalized zinc IRMOFs were investigated for their high-temperature postsynthetic rearrangement (PSR) chemistry to heterocyclic chromenes and benzofurans and then coupled to solid-gas reactions with molecular oxygen. The selectivity for the initial molecular rearrangements was found to be inverted in the porous MOF environment compared to conventional melt reactions, showing the potential of MOFs to give rise to different chemistry. This work contributes to establishing the feasibility of high-temperature solid-gas manifolds for MOF PSM.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
William J. M. Blackaby, Katie L. M. Harriman, Samuel M. Greer, Andrea Folli, Stephen Hill, Vera Krewald, Mary F. Mahon, Damien M. Murphy, Muralee Murugesu, Emma Richards, Elizaveta Suturina, Michael K. Whittlesey
Summary: A new series of homoleptic Ni(I) bis-N-heterocyclic carbene complexes with different torsion angles between the ligands have been reported. The complexes exhibit a strongly anisotropic g-tensor and the first excited state energy ranges from 270 to 650 cm(-1). The magnetic relaxation is dominated by Raman and direct processes, and the temperature dependence of the relaxation does not correlate with the torsion angle.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Thomas G. Linford-Wood, Mary F. Mahon, Matthew N. Grayson, Ruth L. Webster
Summary: This paper presents a synthetic study into the catalytic hydrogen/deuterium exchange of 1 degrees silanes, 2 degrees silanes, and 3 degrees siloxanes facilitated by iron-beta-diketiminato complexes (1a and 1b). Near-complete H/D exchange is observed for various aryl- and alkyl-containing hydro-silanes and hydrosiloxanes. The reaction tolerates alternative hydride source pinacolborane (HBpin) with quantitative H/D exchange. A synthetic and density functional theory (DFT) investigation suggests that a monomeric iron-deuteride is responsible for the H/D exchange.
Article
Chemistry, Multidisciplinary
Kyle G. Pearce, Chiara Dinoi, Michael S. Hill, Mary F. Mahon, Laurent Maron, Ryan S. Schwamm, Andrew S. S. Wilson
Summary: The synthesis and catalytic properties of hydrocarbon-soluble beta-diketiminato phenylcalcium derivatives are discussed in this article. The compounds display different modes of Ca-mu(2)-Ph-Ca bridging and can selectively and uncatalyzedly form biaryls when reacted with aryl bromides.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Lia Sotorrios, Fedor M. Miloserdov, Anne-Frederique Pecharman, John P. Lowe, Stuart A. Macgregor, Mary F. Mahon, Michael K. Whittlesey
Summary: The syntheses, reactivity, and electronic structure analyses of [Ru(PPh3)(2)(ZnMe)(4)H-2] and [Ru(PPh3)(2)(ZnPh)(4)H-2] are reported. [Ru(PPh3)(2)(ZnMe)(4)H-2] exhibits an 8-coordinate Ru center with axial phosphines and a symmetrical (2 : 2) arrangement of ZnMe ligands in the equatorial plane. The ZnMe ligands in [Ru(PPh3)(2)(ZnMe)(4)H-2] undergo facile, sequential exchange with ZnPh2 to give [Ru(PPh3)(2)(ZnPh)(4)H-2], which shows a 3 : 1 arrangement of ZnPh ligands. Mechanisms for ZnMe/ZnPh exchange and isomerization are proposed using DFT calculations, and the relationships of these {Ru(ZnR)(4)H-2} species to isoelectronic Group 8 transition metal polyhydrides and related Schlenk equilibria in the Negishi reaction are discussed.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Han-Ying Liu, Samuel E. Neale, Michael S. Hill, Mary F. Mahon, Claire L. McMullin, Emma Richards
Summary: Ionic compounds containing sodium cations are known for their stability and resistance to redox reactivity. However, when treated with non-reducible organic bases, a low oxidation state {Mg2Na2} species undergoes selective extrusion of sodium metal and oxidation of the Mg-I centers. Quantum chemical studies indicate that intramolecular electron transfer is facilitated by the molecular orbitals of the {Mg2Na2} ensemble.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Laura E. English, Thomas M. Horsley Downie, Catherine L. Lyall, Mary F. Mahon, Claire L. McMullin, Samuel E. Neale, Carla M. Saunders, David J. Liptrot
Summary: The (IPr)CuOtBu catalysed reduction of 11 aryl and alkyl isocyanates with pinacolborane resulted in the formation of boraformamides, pinBN(R)C(O)H, in most cases. Overreduction was observed only for electron poor aryl isocyanates (4-NC-C6H4NCO, 4-F3C-C6H4NCO, 3-O2N-C6H4NCO). Computational analysis revealed that the stability of [(IPr)CuH](2), proposed as the catalyst resting state, influences selectivity and offers a potential solution to prevent overreduction in future work. In the case of iPrNCO, the formation of [(IPr)CuH](2) prevents overreduction kinetically. However, for 4-NC-C6H4NCO, the barrier height for the first step of overreduction is much lower, resulting in unselective reduction.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Kyle G. G. Pearce, Michael S. S. Hill, Mary F. F. Mahon
Summary: Reaction of BeCl2 with dilithium diamide yields the dimeric chloroberyllate, leading to the formation of a 2-coordinate beryllium amide. Reduction of the beryllium amide using lithium or sodium in benzene produces relevant organoberyllate products, likely through transient Be(i) radicals.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Henry T. W. Shere, Michael S. Hill, Samuel E. Neale, Mary F. Mahon, Claire L. McMullin, Andrew S. S. Wilson
Summary: This article investigates the contrasting reactivities of molecular beta-diketiminato (BDI) calcium hydride and n-hexyl derivatives towards bis(pinacolato)diboron (B(2)pin(2)). The study finds that the dimeric calcium hydride forms an unusual diborane(6) dianion, while the initially dimeric organocalcium reagent converts to a calcium diboranate monomer. Attempts to induce heterolysis of the B-B bond in the calcium diboranate monomer were unsuccessful, resulting in either dismutation or the generation of N-donor adduct derivatives. These different reactivities can be explained by density functional theory (DFT) calculations, which attribute them to the larger radius and lower steric congestion of the third-row group 2 cation.
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
(2023)
Article
Chemistry, Inorganic & Nuclear
Anne-Frederique M. Pecharman, Erika M. Roberts, Fedor M. Miloserdov, Victor Varela-Izquierdo, Mary F. Mahon, Michael K. Whittlesey
Summary: The addition of excess ZnMe2 to a mixture of [Ru(PPh3)(3)HCl] and IMes resulted in the formation of a bis-cyclometallated complex [Ru(IMes)(PPh3)(2)] 2 and a mono-cyclometallated Ru-Zn heterobimetallic complex [Ru(IMes)'(PPh3)(2)(ZnMe)] 3. Further reactions of these complexes with H-2, PhSiH3, pinacolborane, and CO were investigated. Compounds 1, 4, 5, and 6 were synthesized and structurally characterized.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Anne-Frederique M. Pecharman, Rosalyn L. Falconer, Esme Owen, Michael J. Cowley, John P. Lowe, Claire L. McMullin, Mary F. Mahon, Michael K. Whittlesey
Summary: Treatment of [Ru(L)(PPh3)2(CO)H2] (L = PPh3, IMes) with an N-mesityl amidophosphine aluminium dihydride complex (Al(P-N)H2) gives [Ru(PPh3)2(CO)H3{Al(P-N)H}] (2) and [Ru(IMes)(PPh3)(CO)H3{Al(P-N)H}] (4), which are present in solution as mixtures of diastereomers. Crystal structure determinations and density functional theory (DFT) calculations suggest both 2 and 4 can be formulated as [Ru(L)(PPh3)(CO)H3][Al(P-N)H] complexes with bridging hydride ligands.
Article
Chemistry, Inorganic & Nuclear
Henry T. W. Shere, Michael S. Hill, Mary F. Mahon
Summary: This contribution describes the formation of homonuclear sigma bonding between boron mediated by alkaline earth metals. The reaction between alkaline earth bis-(trimethylsilyl)amides and bis(pinacolato)diboron resulted in the formation of group 2 silazide diborane adducts. Further reaction with bis(pinacolato)diboron led to the formation of bis-triboranate derivatives. These complexes provide rare examples of catena-boron species with propagated B-B bonds beyond the common diboranes.
Article
Chemistry, Multidisciplinary
Han-Ying Liu, Samuel E. Neale, Michael S. Hill, Mary F. Mahon, Claire L. McMullin, Benjamin L. Morrison
Summary: [{SiNDipp}MgNa](2) reacts directly with H-2 to form a heterobimetallic hydride. Computational density functional theory (DFT) studies suggest that this reactivity is initiated by orbitally-constrained sigma(Mg-Mg)-> sigma*(H-H) and sigma(H-H) -> n*(Na(3s)) interactions between the frontier MOs of both H-2 and the tetrametallic core of [{SiNDipp}MgNa](2).
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Han-Ying Liu, Samuel E. Neale, Michael S. Hill, Mary F. Mahon, Claire L. McMullin
Summary: The copper(i) alumanyl derivative reacts with up to three equivalents of various terminal alkynes, resulting in the sequential formation of cuprous (hydrido)(alkynyl)aluminate, (alkenyl)(alkynyl)aluminate, and bis(alkynyl)aluminate derivatives. The alkene liberation process in the latter step is a unique case of alkyne transfer semi-hydrogenation.