Discovery and Characterization of Atropisomer PH-797804, a p38 MAP Kinase Inhibitor, as a Clinical Drug Candidate

Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase

(2011) Shaun R. Selness et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Substituted N -aryl-6-pyrimidinones: A new class of potent, selective, and orally active p38 MAP kinase inhibitors

(2011) Balekudru Devadas et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and activity of a potent, selective series of N -aryl pyridinone inhibitors of p38 kinase

(2011) Shaun R. Selness et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Kinase inhibitors: a new approach to rheumatoid arthritis treatment

(2010) Stanley Cohen et al.   CURRENT OPINION IN RHEUMATOLOGY

"Go upstream, young man": lessons learned from the p38 saga

(2009) D Hammaker et al.   ANNALS OF THE RHEUMATIC DISEASES

Structural Bioinformatics-Based Prediction of Exceptional Selectivity of p38 MAP Kinase Inhibitor PH-797804

(2009) Li Xing et al.   BIOCHEMISTRY

Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase

(2009) Shaun R. Selness et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective p38α Inhibitors Clinically Evaluated for the Treatment of Chronic Inflammatory Disorders

(2009) David M. Goldstein et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-Inflammatory Properties of a Novel N-Phenyl Pyridinone Inhibitor of p38 Mitogen-Activated Protein Kinase: Preclinical-to-Clinical Translation

(2009) H. R. Hope et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Small Molecule p38 MAP Kinase Inhibitors for the Treatment of Inflammatory Diseases: Novel Structures and Developments During 2006- 2008

(2008) Liping Pettus et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Adalimumab for the treatment of rheumatoid arthritis

(2008) Nobuyuki Miyasaka   Expert Review of Clinical Immunology