期刊
CHEMMEDCHEM
卷 6, 期 6, 页码 1074-1080出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201100100
关键词
Eu-GTP; GPCR; guanosine; nucleosides; receptors
资金
- Italian Ministry for University and Research
- Ministry for Health [RF-CNM-2007-662855]
Guanosine, released extracellularly from neurons and glial cells, plays important roles in the central nervous system, including neuroprotection. The innovative DELFIA Eu-GTP binding assay was optimized for characterization of the putative guanosine receptor binding site at rat brain membranes by using a series of novel and known guanosine derivatives. These nucleosides were prepared by modifying the purine and sugar moieties of guanosine at the 6- and 5'-positions, respectively. Results of these experiments prove that guanosine, 6-thioguanosine, and their derivatives activate a G protein-coupled receptor that is different from the well-characterized adenosine receptors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据