期刊
CHEMMEDCHEM
卷 5, 期 5, 页码 749-756出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201000075
关键词
aggregation; blood platelets; boranes; conjugates; nucleosides
资金
- Polish Ministry of Sciences and Higher Education [N405 051 32/3592]
Novel types of adenosine and 2'-deoxyadenosine derivatives containing boron clusters at positions C2', N6, or C8 were synthesized. The effect of these modified compounds on platelet function was studied. Modification of adenosine at the C2' position with a para-carborane cluster (C2B10H11) results in efficient inhibition of platelet function, including aggregation, protein secretion, and P-selectin expression induced by thrombin or ADP. These preliminary findings and the new chemistry proposed form the basis for the development of a new class of adenosine analogues that modulate human blood platelet activities.
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