期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 39, 页码 11511-11515出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201504317
关键词
drug delivery; electrospun fibers; hydrogels; microparticles; photopatterning
资金
- National Research Foundation of Korea (NRF) through Priority Research Center Program [2009-0093823]
- Active Polymer Center for Pattern Integration at Yonsei University [2007-0056091]
- Yonsei University (Yonsei-SNU Collaborative Research Fund)
Multi-compartmental non-spherical hydrogel microparticles were fabricated by combining electrospinning and photopatterning. Sequential electrospinning produced multi-layered fiber matrices with different composition in which each layer became a compartment of the particle. Photopatterning of the hydrogel in the presence of the multilayered fiber matrix generated multi-compartmental microparticles with different vertical functionalities. While the shapes of the hydrogel microparticles were determined by the design of the photomask, the chemical properties and size of each compartment were independently controlled by changing the molecules incorporated into each fiber matrix and the electrospinning times, respectively. The resultant multi-compartmental hydrogel microparticles could carry out not only the release of different growth factors with independent kinetics but also binding of multiple targets at different compartments.
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