期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 20, 期 45, 页码 14633-14636出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201405102
关键词
alkenes; alkylation; copper; lactones; oxyalkylation
资金
- EPFL (Switzerland)
- Swiss National Science Foundation (SNSF)
A copper-promoted oxyalkylation of alkenes with alkylnitriles has been developed. The protocol provides rapid access to phthalides (-lactones) or isochromanones (-lactones) via the formation of a C(sp(3))C(sp(3)) and a C(sp(3))O bond with the generation of up to two quaternary carbon atoms. Mechanistic studies suggest that this reaction is initiated by the formation of the C(sp(3))C(sp(3)) bond rather than the C(sp(3))O bond. Catalytic conditions were subsequently developed using carboxylic acid as an internal nucleophile.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据