期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 20, 期 31, 页码 9476-9492出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201402649
关键词
analytical methods; nanostructures; nanotechnology; RNA; RNA recognition
资金
- Italian Flagship Project NanoMax
MicroRNAs (miRNAs) are important regulators of gene expression, and many pathological conditions, including cancer, are characterized by altered miRNA expression levels. Therefore, accurate and sensitive quantification of miRNAs may result in correct disease diagnosis establishing these small noncoding RNA transcripts as valuable biomarkers. Aiming at overcoming some limitations of conventional quantification strategies, nanotechnology is currently providing numerous significant alternatives to miRNA sensing. In this review an up-to-date account of nanotechnology-based strategies for miRNA detection and quantification is given. The topics covered are: nanoparticle-based approaches in solution, sensing based on nanostructured surfaces, combined nanoparticle/ surface sensing approaches, and single-molecule approaches.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据