Article
Chemistry, Multidisciplinary
Lichao Su, Yiming Chen, Hongqi Huo, Naishun Liao, Ying Wu, Xiaoguang Ge, Zhiyong Guo, Zhongxiang Chen, Xuan Zhang, Jibin Song
Summary: A novel therapeutic monitoring platform has been developed in this study to monitor the efficacy of photodynamic therapy in real time and evaluate the treatment effect in vivo. This probe can effectively quantify and monitor the concentration and consumption of reactants using chemiluminescence and fluorescence signal changes generated by light excitation, providing strong support for achieving more precise treatment.
Article
Multidisciplinary Sciences
Takeru Takagi, Tasuku Ueno, Keisuke Ikawa, Daisuke Asanuma, Yusuke Nomura, Shin-nosuke Uno, Toru Komatsu, Mako Kamiya, Kenjiro Hanaoka, Chika Okimura, Yoshiaki Iwadate, Kenzo Hirose, Tetsuo Nagano, Kaoru Sugimura, Yasuteru Urano
Summary: The discovery of a new actin-binding small molecule presents an important advance in the field, offering the opportunity to design and synthesize new functional molecules. This molecule enables visualization of the actin cytoskeleton and allows for highly specific control of actin filaments in living cells.
Article
Spectroscopy
Halit Kantekin, Gulpinar Sarki, Ipek Omeroglu, Halise Yalazan, Nuran Kahriman, Mahmut Durmus
Summary: Novel metallo phthalocyanine derivatives with chalcone groups were synthesized and characterized using spectroscopic techniques. The photophysical and photochemical properties of the compounds in DMSO were investigated, showing no aggregation of phthalocyanine complexes.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biochemistry & Molecular Biology
Ksenija Bozinovic, Davor Nestic, Evripidis Michail, Matthias Ferger, Marta Koscak, Christoph Lambert, Dragomira Majhen, Todd B. Marder, Ivo Piantanida
Summary: This study shows that specific compounds can increase cytotoxicity and antiviral activity through irradiation, possibly related to the generation of reactive oxygen species.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Marta Koscak, Isabela Pehar, Ksenija Bozinovic, Goutam Kumar Kole, Sandra Sobocanec, Iva I. Podgorski, Marija Pinteric, Klaus Muller-Buschbaum, Dragomira Majhen, Ivo Piantanida, Todd B. Marder
Summary: Certain methylated pyrene cations exhibit a high affinity for DNA and can be used as probes for DNA detection. Under light irradiation, these cations show increased toxicity against human cell lines and can cause damage to mitochondrial DNA.
Article
Biochemistry & Molecular Biology
Ksenija Bozinovic, Davor Nestic, Evripidis Michail, Matthias Ferger, Marta Koscak, Christoph Lambert, Dragomira Majhen, Todd B. Marder, Ivo Piantanida
Summary: We reported a new type of compound that shows remarkable sensing ability in DNA/RNA and also exhibits biological activity in photodynamic therapy, making them potential therapeutic probes. These compounds can effectively enter living cells with negligible inhibition on cell proliferation. Regarding viruses, some of these compounds have high affinity to adenovirus type 5 and can weaken its ability to infect human cells. Upon visible light irradiation, these compounds generate reactive oxygen species, resulting in a significant increase in cytotoxicity and antiviral activity.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Binlong Chen, Ye Yang, Yaoqi Wang, Yue Yan, Zenghui Wang, Qingqing Yin, Qiang Zhang, Yiguang Wang
Summary: The SPR-SOSG nanosensor has been developed to specifically illuminate singlet oxygen in endocytic organelles through encoding SOSG into pH-sensitive micelles, achieving more than 10-fold amplification of the singlet oxygen signal.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Inorganic & Nuclear
Luca Conti, Silvia Ciambellotti, Gina Elena Giacomazzo, Veronica Ghini, Lucrezia Cosottini, Elisa Puliti, Mirko Severi, Emiliano Fratini, Francesca Cencetti, Paola Bruni, Barbara Valtancoli, Claudia Giorgi, Paola Turano
Summary: This study reports the successful encapsulation of two highly charged metal complexes into human H-ferritin, resulting in highly luminescent nanocomposites with great stability. The singlet oxygen sensitizing properties of the metal complexes are maintained in their encapsulated form. The nanocomposites are exclusively internalized by cancer cells and exhibit a marked dose-dependent cytotoxic effect against cancer cells upon light activation.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Inorganic & Nuclear
Chaochao Fan, Yue Wang, Jie Zhao, Yanxia Zhao, Dong Yang, Boyang Li, Le Yu, Xiao-Juan Yang, Biao Wu
Summary: In this study, two photoactive ligands were designed and used to construct sulfate complexes. These complexes can undergo oxygenation reactions under light, storing singlet oxygen, and partially recover the original structures after heating.
INORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Wojciech Krzemien, Monika Rohlickova, Miloslav Machacek, Veronika Novakova, Jaroslaw Piskorz, Petr Zimcik
Summary: Halogenation in the 2,6 position of BODIPY dyes significantly increases the singlet oxygen production, enhancing the photodynamic properties and anti-cancer activity against skin melanoma cancer cells. These compounds primarily induce apoptosis in cancer cells while maintaining limited dark toxicity.
Article
Chemistry, Multidisciplinary
Marie Halaskova, Filip Kostelansky, Jiri Demuth, Ingrid Hlbocanova, Miroslav Miletin, Petr Zimcik, Miloslav Machacek, Veronika Novakova
Summary: Effective interaction with biomembranes is crucial for the activity of photosensitizers. In this study, amphiphilic cationic phthalocyanines with different bulkiness of substitution on the lipophilic part (-H, -SMe, -StBu) were prepared and their interaction with biomembranes was investigated. The results showed that even the bulky -StBu derivatives could enter biomembranes and exhibited good photosensitizing activity. Moreover, these derivatives demonstrated excellent anti-tumor activity in various cell lines.
Article
Engineering, Environmental
Yanyan Zhu, Ying Yang, Ning Li, Chai Luo, Xiaohong Hou
Summary: This study has successfully developed a multifunctional nanoplatform integrating PDT effect, O2 self-sufficiency, and intracellular 1O2 self-monitoring to enhance the efficacy of PDT.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Arunavo Chatterjee, Ankit Kumar Sharma, Pradipta Purkayastha
Summary: In this study, a method utilizing non-ionic surfactant vesicular systems to generate reactive oxygen species was reported. This method involves a FLIM-FRET technique using yellow emissive carbon dots and methylene blue trapped in niosomes. Niosomes are biologically important due to their good stability and extremely low toxicity.
Review
Chemistry, Inorganic & Nuclear
Suman Joseph, S. K. Ashok Kumar
Summary: Singlet oxygen (1O2) plays an important role in chemistry, medicine, and human physiology, but its use in biological systems is limited due to a lack of efficient probes. This review discusses the current developments of probes and molecular carriers of 1O2, which typically consist of a 1O2-specific binding unit and a signaling unit. Based on the signaling mode, these probes can be categorized into absorption-based, colorimetric, photoluminescent, and chemiluminescent. The review also highlights the factors affecting their efficiency and identifies unexplored areas for potential future developments.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Chemistry, Inorganic & Nuclear
Hande Gunduz, Safacan Kolemen, Engin U. Akkaya
Summary: The detection and imaging of singlet oxygen is a challenging task due to its short half-life and solvent sensitivity. Selective probes for singlet oxygen are crucial in the presence of other oxidizing species, and smart designs are already making progress in pushing signalling events towards longer wavelengths of the visible spectrum.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Tomer Babu, Hiba Ghareeb, Uttara Basu, Hemma Schueffl, Sarah Theiner, Petra Heffeter, Gunda Koellensperger, Norman Metanis, Valentina Gandin, Ingo Ott, Claudia Schmidt, Dan Gibson
Summary: Au-I-carbene and Pt-IV-Au-I-carbene prodrugs exhibit low to sub-mu M activity against various cancer cell lines and overcome cisplatin resistance. The most potent prodrug is achieved by linking a cisplatin-derived Pt-IV(phenylbutyrate) complex to an Au-I-phenylimidazolylidene complex 2. In vivo tests on Lewis Lung Carcinoma demonstrate that the prodrug Pt-IV(phenylbutyrate)-Au-I-carbene (7) and the co-administration of cisplatin:phenylbutyrate:2 efficiently inhibit tumor growth (approximately 95%), surpassing the effectiveness of 2 (75%) or cisplatin (84%), while only causing 5% body weight loss compared to 14% for 2, 20% for cisplatin, and >30% for the co-administration.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Kai Zhang, Philip A. A. Hope, Melissa E. El Bitar Nehme, Anthony Linden, Bernhard Spingler, Michel Rickhaus
Summary: This study presents the synthesis, characterization, and properties of a heterocyclic compound containing three fused heptagon rings. The unique strained structure and self-assembly properties of the compound result in red-shifted absorption and concentration-dependent emission profiles. Additionally, the compound exhibits a lower oxidation potential compared to its non-bridged analog. This research opens up new avenues for understanding the structure-property relationships of curved pi-aromatics and constructing increasingly complex pi-frameworks.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Hugo Madec, Francisca Figueiredo, Kevin Cariou, Sylvain Roland, Matthieu Sollogoub, Gilles Gasser
Summary: The development of organometallic catalysis has expanded the toolbox of synthetic chemists and paved the way for bio-compatible reactions in water. Performing metal-catalysed reactions within living cells or organisms poses additional constraints, requiring metal complexes with good efficiency, low concentration, cell specificity, cellular uptake, and low toxicity.
Article
Chemistry, Multidisciplinary
Lili Wang, Johannes Karges, Fangmian Wei, Lina Xie, Zhuoli Chen, Gilles Gasser, Liangnian Ji, Hui Chao
Summary: Conventional photodynamic therapy mainly affects primary tumors, while complementary immunotherapy is effective in eliminating small, non-localized tumors. We report the development of a highly potent immunogenic cell death inducing photosensitizer, Ir-pbt-Bpa, for two-photon photodynamic immunotherapy against melanoma. Upon light irradiation, Ir-pbt-Bpa can induce cell death through a combination of ferroptosis and immunogenic cell death, leading to a strong reduction in tumor size.
Article
Chemistry, Inorganic & Nuclear
Manuel Luca Besmer, Henrik Braband, Thomas Fox, Bernhard Spingler, Alfred P. Sattelberger, Roger Alberto
Summary: This study investigates the role of metal-ligand cooperativity in the activation of various bonds using a radioactivetransition metal Tc-99 compound. The compound showed reactivity with CO2 and H-2, resulting in the formation of new complexes. Different ligands were isolated through reactions and their spectroscopic analyses were performed. The study demonstrates the application of metal-ligand cooperativity on substrates with weakly acidic protons.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Lukas Schneider, Martina Kalt, Samuel Koch, Shanmugi Sithamparanathan, Veronika Villiger, Johann Mattiat, Flavia Kradolfer, Ekaterina Slyshkina, Sandra Luber, Mathias Bonmarin, Caroline Maake, Bernhard Spingler
Summary: This article reports six novel and easily accessible BODIPY-based agents for cancer treatment that exhibit both photodynamic and photothermal activities, and do not rely on the generation of reactive oxygen species for cytotoxicity. These agents demonstrate high photocytotoxicity and low dark toxicity in different cancer cell lines. Under hypoxic conditions, they exhibit oxygen-independent photothermal mechanisms, making them potential candidates for overcoming limitations in current cancer therapy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Inorganic & Nuclear
Reinhard Thaler, Holger Kopacka, Klaus Wurst, Thomas Mueller, Florian R. Neururer, Stephan Hohloch, Petra Lippmann, Ingo Ott, Benno Bildstein
Summary: New clathrochelate complexes of manganese, iron, and cobalt containing organometallic manganese moieties cymantrene or tromancenium were synthesized via self-assembly from dioximes, metal templates, and boronic acid pinacol esters. These complexes are air-stable, highly colored, oligometallic assemblies with complicated magnetic and electrochemical properties. The tetrametallic complexes with tromanceniumyl substituents exhibit promising anticancer activity against different tumor cell lines.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Lea P. Gergely, Cigdem Yuceel, Umit Isci, Florentin S. Spadin, Lukas Schneider, Bernhard Spingler, Martin Frenz, Fabienne Dumoulin, Martina Vermathen
Summary: In this study, PVP and F127 micelles were found to have high encapsulation abilities for water-soluble zinc phthalocyanine molecules and efficiently catalyze singlet oxygen formation. This result suggests that polymeric micelles can serve as effective delivery systems to optimize the performance of phthalocyanine molecules as photosensitizers.
MOLECULAR PHARMACEUTICS
(2023)
Article
Multidisciplinary Sciences
Joseph F. Woods, Lucia Gallego, Amira Maisch, Dominik Renggli, Corrado Cuocci, Olivier Blacque, Gunther Steinfeld, Andres Kaech, Bernhard Spingler, Andreas Vargas Jentzsch, Michel Rickhaus
Summary: This study demonstrates that the process of shape-assisted self-assembly is consistent across various derivatives, highlighting the restriction of rotational motion. This finding is important for precise molecular self-assembly and the generation of new materials.
NATURE COMMUNICATIONS
(2023)
Article
Crystallography
Bernhard Spingler
Summary: The crystal structure of a biologically active compound reveals a network of hydrogen bonding interactions.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Sarah Boumati, Angelique Sour, Valerie Heitz, Johanne Seguin, Gautier Beitz, Yusuke Kaga, Marta Jakubaszek, Johannes Karges, Gilles Gasser, Nathalie Mignet, Bich-thuy Doan
Summary: Researchers have successfully used a theranostic agent with combined diagnostic and therapeutic capabilities for photodynamic therapy, fluorescence imaging, and magnetic resonance imaging. The experimental results show that this theranostic agent has a significant impact on tumor growth and has the potential to become a drug candidate for cancer.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Inorganic & Nuclear
Silvio Jakopec, Lisa Gourdon-Grunewaldt, Ivona Cipor, Andrijana Mescic Macan, Berislav Peric, Ivo Piantanida, Kevin Cariou, Gilles Gasser, Srecko I. Kirin, Silvana Raic-Malic
Summary: Bioorganometallic complexes have shown promise for potential application in cancer treatment and diagnosis, as well as in bioimaging agents, with some acting as theranostic agents. A series of novel complexes with bidentate pyridyl-1,2,3-triazole and 2,2'-dipyridylamine ligands were prepared and characterized. The complexes exhibited interactions with biomacromolecules and showed significant antiproliferative activity on colon cancer cells.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Sara Benetti, Maria Dalla Pozza, Lorenzo Biancalana, Stefano Zacchini, Gilles Gasser, Fabio Marchetti
Summary: Novel diiron vinyliminium complexes were synthesized and characterized by various spectroscopic techniques. Their solubility in D2O, Log Pow coefficients, and stability in aqueous media were determined. The antiproliferative activity of these complexes on cancer cell lines was evaluated and their mechanism of action was investigated by assessing their influence on mitochondrial respiration.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Yandong Ma, Zhihua Zhang, Fan Sun, Pierre Mesdom, Xin Ji, Pierre Burckel, Gilles Gasser, Min-Hui Li
Summary: Polymer micelles/vesicles made of a red-light-responsive block copolymer are developed as a model system for anticancer phototherapy. The system can release Ru complexes and generate ROS under red-light irradiation, leading to high cytotoxicity against cancer cells.
Article
Chemistry, Multidisciplinary
Mihyun Park, Claudia Schmidt, Sebastian Tuerck, Franziska Hanusch, Simone V. Hirmer, Ingo Ott, Angela Casini, Shigeyoshi Inoue
Summary: A dinuclear gold(I) complex with a strongly donating bis-N-heterocyclic imine ligand was synthesized and characterized. It showed highly selective anticancer effects against non-small cell lung cancer cells, particularly A549 cells. The anticancer effects were not correlated with the amount of gold uptake by the cells but correlated with its selective inhibition of cancer cells overexpressing a specific enzyme.