期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 20, 期 44, 页码 14410-14420出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201403372
关键词
antitumor agents; biological activity; ligands; metallacycles; self-assembly; supramolecular chemistry
资金
- Basic Science Research program through the National Research Foundation of Korea (NRF)
- Ministry of Science, ICT and Future Planning [NRF-2013R1AA2006859]
- Priority Research Centers program through the NRF [2009-0093818]
- National Research Foundation of Korea (NRF) - Korea government (MSIP) [NRF-2010-0027963]
- Kwangwoon University
- NIH
Two new tetracationic hetero-bimetallacycles, compounds 4 and 5, have been constructed from an N,N-bis(4-(pyridin-4-ylethynyl)phenyl)pyridine-2,6-dicarboxamide ligand (1), and cis-blocked complexes [M(dppf)(OTf)(2)] (dppf=1,1-bis(diphenylphosphino)ferrocene; OTf=trifluoromethanesulfonate; M=Pd (2), Pt (3)) in CH3NO2/CH2Cl2 (1:1) solvent. Both complexes were isolated with adequate yields as triflate salts and were then characterized using H-1, C-13, and (PNMR)-P-31 spectroscopy, elemental analysis, UV/Vis spectroscopy, and high-resolution electrospray mass spectrometry (HR-ESMS). The molecular structure of 4 was determined by molecular mechanics force-field calculations. The cytotoxic effect of both new complexes were analyzed against T98G (brain tumor), KB (head and neck cancer), SNU-80 (thyroid cancer), and HEK-293 non-malignant cell lines. The cytotoxicity of complexes 4 and 5 were found to be considerably more effective against cancer cells than reference drug cisplatin. Annexin-V/PI staining, caspase-3/7 activity, and the reduction in mitochondrial membrane potential justify a significant level of apoptosis in complex-treated cells.
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