Article
Pharmacology & Pharmacy
Drashti Shah, Menitte Eroy, John Fakhry, Azophi Moffat, Kevin Fritz, Houston D. Cole, Colin G. Cameron, Sherri A. McFarland, Girgis Obaid
Summary: Mic-ML18J03, a micellar formulation of ML18J03, significantly enhances its luminescence yield and accumulative signals in tumors, providing tumor selectivity and overcoming concentration-dependent quenching. This formulation also reduces spectral shifting of the emission maxima during PDT and increases the production of reactive molecular species, highlighting its potential as a versatile approach for in vivo luminescence imaging.
Article
Chemistry, Analytical
Yu-Bin Su, Xu Zhao, Li-Jian Chen, Hai-Long Qian, Xiu-Ping Yan
Summary: The development of a novel theranostic nanoprobe for imaging-guided PDT is reported in this study. The nanoprobe integrates PLNP for autofluorescence-free bioimaging, TCPP for PDT, and AS1411 aptamer-contained DNA for specific binding to cancer cells. This work provides a new imaging-guided PDT nanoplatform for theranostics.
Article
Multidisciplinary Sciences
Kai Chang, Leyi Xiao, Yuanyuan Fan, Juqing Gu, Yunsheng Wang, Jie Yang, Mingzhou Chen, Yufeng Zhang, Qianqian Li, Zhen Li
Summary: Metastasis is the main cause of cancer-related deaths, and early detection of tumor metastasis is crucial for better prognoses. In this study, a phosphorescence imaging method using organic nanoparticles was developed to detect microenvironmental changes associated with early tumor metastasis, allowing for early detection before the formation of secondary tumors. This method demonstrated superior sensitivity and convenience compared to other imaging methods, detecting metastases as early as day 3 in experimental models.
Article
Chemistry, Multidisciplinary
Yameng Li, Yingjie Ding, Yifan Zhang, Zhiyue Sun, Jiao Liu, Mengxia Dai, Jiayi Feng, Bin Li, Chaozhan Wang, Yinmao Wei, Ji-Wei Shen
Summary: In this study, a novel nanomaterial UCFS@Fe-TA was developed for simultaneous photodynamic therapy (PDT), photothermal therapy (PTT), and chemodynamic therapy (CDT) triggered by single 808 nm laser. The nanomaterial exhibited intense red emission and faster generation of reactive oxygen species at higher temperatures, resulting in efficient tumor suppression.
Article
Chemistry, Physical
Kikuya Hayashi, Kei Fukasawa, Takashi Yamashita, Shuzo Hirata
Summary: In this study, we report a rational design of triplet sensitizers to achieve high-efficiency red afterglow emission at room temperature. By synthesizing sensitizer and acceptor molecules with different conjugated substituents, we found that the long conjugated substituent greatly enhanced the phosphorescence resonance energy transfer (PRET) from the sensitizer to the acceptor, resulting in improved yield of red afterglow emission at room temperature.
CHEMISTRY OF MATERIALS
(2022)
Article
Chemistry, Analytical
Shengqiang Hu, Lixian Huang, Liuyan Zhou, Tingchan Wu, Shulin Zhao, Liangliang Zhang
Summary: This research focuses on the integration of ratiometric NIR-II fluorescence imaging and chemo-/photodynamic combination therapy for accurate diagnosis and efficient treatment of deep tumors. By conjugating dual-ligands-stabilized gold nanoclusters (cgAuNCs) into down-/up-conversion nanoparticles (D/UCNPs), single-excitation triple-emission nanoassemblies were prepared, enabling simultaneous imaging and therapy upon exposure to an 808 nm laser. The study provides insights into the design of multifunctional nanoplatforms for tumor diagnosis and treatment.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Huaixin Zhao, Linghui Li, Feng Li, Chunxia Liu, Mengxue Huang, Jiao Li, Feng Gao, Xinhua Ruan, Dayong Yang
Summary: A DNA nanocomplex is developed for photodynamic therapy (PDT) in breast cancer, enabling tumor-site glutathione-activated therapy without the need for external laser excitation. The nanocomplex integrates persistent-luminescence nanoparticles (PLNPs) as a self-illuminant to activate a photosensitizer and inhibit tumor growth through the production of cytotoxic oxygen.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xu Zhao, Kai-Chao Zhao, Li-Jian Chen, Yu-Shi Liu, Jia-Lin Liu, Xiu-Ping Yan
Summary: This study presents a design of an acid-activated and continuous external irradiation-free photothermal and photodynamic synchronous theranostic nanoplatform for precision tumor-targeting near-infrared image-guided therapy. The platform offers advantages of reversible activation, synergistic enhancement, tumor targetability, and continuous external irradiation-free properties.
Article
Biotechnology & Applied Microbiology
Xuzi Cai, Kang-Nan Wang, Wen Ma, Yuanyuan Yang, Gui Chen, Huijiao Fu, Chunhui Cui, Zhiqiang Yu, Xuefeng Wang
Summary: The newly designed Ir-NPs showed high tumor-targeting ability, excellent antitumor effect, and low toxicity, making them a promising candidate for clinical applications in bioimaging and PDT. Additionally, they also demonstrated potential as a two-photon imaging agent for deep tissue bioimaging.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Nanoscience & Nanotechnology
Aurelie Bessiere, Jean-Olivier Durand, Camille Nous
Summary: PerL materials, in the form of nanoparticles, have shown great potential as bio-nanoprobes for in vivo small animal imaging and photodynamic therapy in deep-seated tissues. The physical association and targeting ability of PerL materials and photosensitizers, as well as the versatility in excitation protocols, play important roles in their successful application.
Article
Materials Science, Multidisciplinary
Kikuya Hayashi, Keiki Fukumoto, Shuzo Hirata
Summary: In this study, improved resolution of bright afterglow emission was achieved by performing photoinduced triplet depletion. Triplet depletion was achieved by charge separation through photoionization from a triplet state caused by depletion and subsequent rapid singlet formation. A higher-resolution afterglow image with an improvement of 25% was obtained by simultaneous focusing of a donut-shaped depletion beam and an excitation beam.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Physical
Qianwen Zhou, Ming Xu, Wei Feng, Fuyou Li
Summary: This study presents a method to measure the PLQY of afterglow materials by collecting the luminescent dynamic curves of emission and excitation light, and finds that the emitted photons of this type of material are directly proportional to the excitation time, indicating that the PLQY is independent of the excitation time.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Physical
Jingyi Lai, Bo Zhou, Ke-Zhi Wang, Dongpeng Yan
Summary: In this work, a series of layered double hydroxide (LDHs) nanosheets with red long-afterglow were fabricated by utilizing highly efficient triplet-triplet energy transfer. The Zn-based LDHs@RhB composite exhibited an energy transfer efficiency as high as 95.18% and could even generate red long-afterglow under white-light irradiation. Therefore, the LDHs@RhB composites show great potential in the fields of anticounterfeiting and information encryption.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Engineering, Biomedical
Qiang Wang, Nian Liu, Zhenyu Hou, Junpeng Shi, Xinhui Su, Xiaolian Sun
Summary: A novel I-131 labeled nanoplatform with Cerenkov radiation capability was developed for radiotherapy and radiation-induced photodynamic therapy, showing excellent tumor inhibition in both in vitro and in vivo models. The combination of self-activated PDT and RT has the potential to greatly benefit deep tumor therapy.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Analytical
Mozhgan Samandarsangari, Daria O. Kozina, Victor V. Sokolov, Anastasia D. Komarova, Marina V. Shirmanova, Ilya S. Kritchenkov, Sergey P. Tunik
Summary: In this study, new phosphorescent iridium complexes were synthesized with water-soluble and biocompatible properties. The major photophysical characteristics were determined by two cyclometallating ligands based on 2-pyridine-benzothiophene. The use of various diimine ligands influenced the quantum yield of phosphorescence and the sensitivity to oxygen. The complexes demonstrated low toxicity and good water solubility.
Article
Chemistry, Multidisciplinary
Chao Li, Yucong Gao, Yuanyue Wang, Jie Wang, Jiaomin Lin, Jing Du, Zhiguo Zhou, Xiaoming Liu, Shiping Yang, Hong Yang
Summary: The synthesized IrPc-NPs nano-assembly exhibits bifunctionality, alleviating the hypoxia of tumor cells and improving the efficacy of sonodynamic therapy (SDT). It also shows excellent biocompatibility, benignancy towards overall tumor growth in vivo, and the controllability of timely applying ultrasound (US) irradiation during treatment.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Fengfeng Xue, Shuntao Zhu, Qiwei Tian, Ruomeng Qin, Zerong Wang, Gang Huang, Shiping Yang
Summary: Magnetothermal therapy (MHT) is a promising non-/minimal invasive and efficient approach for tumor treatment. However, the development of small MHT agents (< 50 nm) with excellent magnetothermal conversion performance and high tumor enrichment remains challenging. In this study, a macrophage-mediated delivery system was designed for enhanced magnetic resonance imaging (MRI) and MHT of solid tumors using small Fe@Fe3O4-DHCA nanoparticles. The aggregation of Fe@Fe3O4-DHCA nanoparticles in macrophages resulted in enhanced MRI and magnetothermal performance in vitro. Moreover, the in vivo MHT effect of macrophages loaded with Fe@Fe3O4-DHCA was superior to that of Fe@Fe3O4-DHCA alone, attributed to the tumor-targeting capability of macrophages. This macrophage-mediated delivery system presents a new strategy for enhanced MHT based on Fe@Fe3O4-DHCA nanoparticles, with great potential for clinical tumor therapy.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Materials Science, Biomaterials
Yeping Liu, Likai Wang, Fengyuan Wei, Ya Tian, Juan Mou, Shiping Yang, Huixia Wu
Summary: In this study, a smart Mn3O4/OCN-PpIX@BSA nanoplatform was developed to enhance the combinational therapeutic efficacy of CDT and SDT through TME modulation. The nanoplatform effectively catalyzed endogenous H2O2 to produce O-2, relieved hypoxia, and generated oxidative stress by releasing Mn2+ ions. The results provide a new strategy for the construction of TME-regulating smart theranostic nanoagents.
BIOMATERIALS SCIENCE
(2023)
Article
Materials Science, Biomaterials
Qi Yang, Yajun Yu, Chaojie Tang, Yucong Gao, Wu Wang, Zhiguo Zhou, Shiping Yang, Hong Yang
Summary: We developed iridium(iii)-cyanine complex/bovine serum albumin-based nanoparticles conjugated with folic acid, which can serve as a photoacoustic imaging probe for lymph node imaging. These nanoparticles exhibit good biocompatibility, strong near-infrared absorption, and impressive lymph node accumulation. Our study demonstrates the potential of this new photoacoustic imaging technique for real-time imaging and quantitative analysis of lymph nodes, providing a more efficient and reliable evaluation method for lymphadenectomy.
BIOMATERIALS SCIENCE
(2023)
Article
Materials Science, Biomaterials
Likai Wang, Ya Tian, Kexin Lai, Yeping Liu, Juan Mou, Shiping Yang, Huixia Wu
Summary: Ultrasound-triggered sonodynamic therapy (SDT) has gained significant attention as a non-invasive and deep tissue penetration alternative for cancer treatment. However, the efficacy of SDT alone is limited by the hypoxic nature of solid tumors. Therefore, this study develops an intelligent theranostic nanoplatform that combines SDT and nitric oxide (NO) therapy to enhance cancer treatment.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Engineering, Environmental
Jufeng Chen, Fengfeng Xue, Wenxian Du, Xi Deng, Yiji Wu, Hangrong Chen
Summary: Endogenous activated nanomedicines have significant potential in cancer therapy by improving therapeutic efficacy and reducing side effects. In this study, a novel nanomedicine (CuHCF) was developed based on a mixed-metal Prussian blue analogue, which could respond to endogenous labile iron pool achieving enhanced chemodynamic therapy and in situ NIR-II photothermal therapy of the tumor. The CuHCF showed low Fenton catalytic activity but significantly amplified reactive oxidative species generation when exposed to over-expressed Fe2+ in the tumor region via redox cycles. Furthermore, CuHCF exhibited enhanced near-infrared absorption and enabled in situ hyperthermia under NIR-II irradiation. Synergistic therapy of CDT/PTT was achieved by combining CuHCF with the ferroptosis inducer erastin.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Hai -Lin Zhang, Yi Wang, Qi Tang, Bing Ren, Shi-Ping Yang, Jin -Gang Liu
Summary: A hollow mesoporous manganese dioxide-based multifunctional nanoplatform was developed for synergistic cancer treatment, which loaded a histone deacetylase inhibitor AFIPB in its hollow cavity and covalently decorated a ruthenium nitrosyl donor and a folic acid targeting group on its covered polydopamine layer. The nanoplatform exhibited tumor microenvironment-responsive properties and could deplete glutathione to disrupt the antioxidant defense system and deliver drugs on demand. Furthermore, it could generate highly toxic hydroxyl radicals through the catalysis of released Mn2+ and produce controlled nitric oxide delivery and significant photothermal effect under 808 nm light irradiation, resulting in high mortality of cancer cells.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Engineering, Biomedical
Shi-Xiong Chen, Ji Zhang, Fengfeng Xue, Wei Liu, Yichen Kuang, Bingxin Gu, Shaoli Song, Hangrong Chen
Summary: In this study, a novel hydrogel containing AQ4N was developed to remodel the tumor hypoxic microenvironment, and combined with Pazopanib to inhibit lung metastasis, resulting in a synergistic effect for chemotherapy.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Jing He, Wei He, Run Wang, Jingjing Jiao, Shiping Yang
Summary: We developed a nanoplatform for combined chemotherapy and enhanced chemodynamic therapy by self-assembling a water-soluble and amphipathic ferrous metallacage (FM), hydrophilic copolymer (PEG2000-COOH), and oxaliplatin (OXA). The FM acted as a catalyst for the Fenton reaction and potential agent for chemodynamic therapy. OXA not only served as an anti-tumor drug but also activated intracellular enzymes to enhance the chemodynamic therapy effect. In vitro and in vivo experiments demonstrated that FM@OXA-PEG showed minimal toxicity to normal cells, while effectively killing tumor cells and inhibiting tumor growth.
MATERIALS ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Kaiwen Chen, Xiangwei Wang, Xiaoping Xu, Xiao Wang, Simin He, Jianping Zhang, Yuyun Sun, Shiping Yang, Shaoli Song
Summary: A novel HER2-targeted PET imaging probe was successfully developed, showing significant potential for the detection of HER2 expression in tumors.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Shasha Zhao, Kexin Lai, Zhen Gao, Xueli Ye, Juan Mou, Shiping Yang, Huixia Wu
Summary: This article introduces a clever combination of nano-enzymes and therapeutic drugs that can promote the production of reactive oxygen species (ROS) in cancer cells, enhancing the therapeutic efficacy of nanomedicines on malignant tumors. By loading the specific drug onto PEGylated Ce-doped hollow mesoporous silica nanoparticles, a smart nanoplatform is constructed to improve tumor therapy efficiency. The carrier showed multi-enzyme activities, with Ce3+ ions converting endogenous H2O2 into highly toxic OH for chemodynamic therapy and Ce4+ ions exhibiting catalase-like activity to reduce tumor hypoxia and glutathione (GSH) peroxidase-mimicking properties to effectively deplete GSH in tumor cells. Moreover, the loaded drug disrupts mitochondrial functions, causing the accumulation of superoxide anions (O-2(-)) and H2O2 within tumor cells. By combining the advantages of the carrier and the drug, the prepared nanoplatform can efficiently induce cancer cell death and inhibit tumor growth through significantly enhanced ROS production. Therefore, this positive combination therapy strategy has a promising application prospect for enhancing antitumor efficacy.
Article
Materials Science, Biomaterials
Minmin Liang, Weixiu Zhou, Haifeng Zhang, Jutian Zheng, Jiaomin Lin, Lu An, Shiping Yang
Summary: In this study, a pH- and glutathione (GSH)-responsive T-1-T-2 dual-mode contrast agent, Fe3O4@ZIF-8-Zn-Mn nanoparticles (NPs), was constructed to improve the sensitivity and accuracy of magnetic resonance imaging (MRI). The NPs showed good stability and weak T-1-T-2 dual-mode MRI contrast effect under neutral conditions, but could be disassembled and release Fe3O4 NPs and paramagnetic Mn2+ ions under acidic environment (pH = 6.5-5.5) and in the presence of GSH (0-4 mM), resulting in enhanced T-1 and T-2 imaging performances. In vivo MRI experiments demonstrated the potential of Fe3O4@ZIF-8-Zn-Mn NPs as a tumor microenvironment-responsive T-1-T-2 dual-mode contrast agent for sensitive tumor imaging.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
