期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 20, 期 20, 页码 5866-5873出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201304891
关键词
DNA computation; DNA nanobiotechnology; logical systems; nucleic acids
资金
- Society for Analytical Chemists of Pittsburgh
- National Instrumentation Program (NIP) of China
- National Key Scientific Program of China [2011CB911000]
- NSFC [NSFC 21221003, NSFC 21327009]
- China National Instrumentation Program [2011YQ03012412]
- National Institutes of Health [GM079359, CA133086]
Researchers increasingly visualize a significant role for artificial biochemical logical systems in biological engineering, much like digital logic circuits in electrical engineering. Those logical systems could be utilized as a type of servomechanism to control nanodevices in vitro, monitor chemical reactions in situ, or regulate gene expression in vivo. Nucleic acids (NA), as carriers of genetic information with well-regulated and predictable structures, are promising materials for the design and engineering of biochemical circuits. A number of logical devices based on nucleic acids (NA) have been designed to handle various processes for technological or biotechnological purposes. This article focuses on the most recent and important developments in NA-based logical devices and their evolution from in vitro, through cellular, even towards in vivo biological applications.
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