期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 19, 期 52, 页码 17891-17898出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201303239
关键词
apoptosis; endosomal escape; nanomaterials; proteins; therapeutics
资金
- Wellcome Trust [WT094114MA]
A low native membrane permeability and ineffective access to the cellular cytosol, together with aggressive proteolytic degradation, often severely hampers the practical application of any therapeutic protein or antibody. Through engineering the charging profile of mesoporous silica nanoparticles, cellular uptake and subsequent subcellular distribution can be controlled. We show herein that programmed cell death can subsequently be induced across a population of cancer cells with remarkable efficacy on conjugating a specific caspase-cascade-activating cytochrome to such cytosol-accessing particles.
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