期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 20, 期 1, 页码 68-71出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201304297
关键词
direct aldol reactions; thioamides; thuggacins; total synthesis; tuberculosis
资金
- JST
- ACT-C
- JSPS KAKENHI [25713002]
- JSPS
- Grants-in-Aid for Scientific Research [12J10748, 25713002] Funding Source: KAKEN
An enantioselective total synthesis of thuggacinB, a natural product exhibiting antibiotic activity against Mycobacterium tuberculosis, is described. Asymmetric direct aldol reactions promoted by Cu and Zn catalysts play a pivotal role in constructing four stereogenic centers. The use of direct aldol reactions as the initial steps for the synthesis of two key fragments allowed the construction of the other stereogenic centers through chirality transfer.
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