Article
Materials Science, Biomaterials
Yi Wang, Tong Lei, Jinghui Zhang, Lei Gong, Yanjie Yang, Xiaolin Ma, Yongqiang Wen, Hongwu Du, Dongdong Qi, Yongzhong Bian, Zhiqiang Liu, Jianzhuang Jiang
Summary: A new two-photon fluorescent viscosity rotor combining an electron-rich unit with an electron-deficient fluorophore was developed for ratiometric two-photon fluorescent detection of intracellular viscosity. The rotor showed sensitive fluorescence responses to changes in viscosity in a methanol/glycerol system, and also displayed good cell imaging performance and targeting ability in living cells.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Chemistry, Inorganic & Nuclear
Wei Quan, Wenhui Song, Qian Zhang, Huawei Huang, Weiying Lin
Summary: The liver, as the metabolic and detoxification center, plays a vital role in various physiological processes. Normal liver function is crucial for maintaining overall health, while abnormal liver function can lead to liver diseases. Early diagnosis of liver diseases is essential for timely treatment. The use of fluorescent probes for detecting biomarkers of liver diseases has provided valuable insights for pathological studies, drug development, and disease diagnosis and treatment in recent years. This review summarizes the progress of fluorescence probes in detecting hepatopathy-related biomarkers and discusses the current challenges and future directions. The development of long wavelength probes, multi-detection probes, quantitative analysis probes, and multi-modal probes is expected to be a popular trend. This review aims to facilitate the development of novel fluorescent probes for disease detection and provide guidance for diagnosis and treatment.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Medicine, Research & Experimental
Xiaoning Zhang, Shasha Li, Huizhen Ma, Hao Wang, Ruiping Zhang, Xiao-Dong Zhang
Summary: NIR-II imaging technology has made significant progress in diagnosing diseases with its high resolution and deep tissue penetration capabilities. Activatable NIR-II fluorescence probes show great potential in reporting pathological changes, exhibiting tunable properties and excellent biocompatibility.
Article
Chemistry, Analytical
Eigirdas Skuodis, Karolis Leitonas, Alexander Panchenko, Lesia Volyniuk, Rasa Keruckiene, Dmytro Volyniuk, Boris F. Minaev, Juozas V. Grazulevicius
Summary: This study reports a new approach to enhance the room-temperature phosphorescence (RTP) of organic triplet emitters through conformer induction. The synthesized compound exhibits stable RTP with a quantum yield of 54%, and can be used for simple detection of oxygen by human eye.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Peiyao Xie, Jianfei Liu, Xiaopeng Yang, Weimin Zhu, Yong Ye
Summary: This study developed a novel fluorescent probe, TPA-SO2, which can detect both the polarity and SO2 of lipid droplets. The probe exhibited sensitivity to polarity decrease and SO2 and specifically targeted cellular lipid droplets.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Daniel Iglesias, Raul Martin, Miguel A. Alvarez-Sanchez, Irene Badia-Dominguez, Ester Vazquez, M. Carmen Ruiz Delgado, Pilar Prieto, M. Antonia Herrero
Summary: Carbon nanohorns were non-covalently functionalized with two different benzothiadiazoloquinoxalines via Stille cross-coupling reactions and solvent-free microwave irradiation. The organic molecules and nanostructures exhibited close interactions, leading to significant Raman enhancement and making them appealing for various applications. Both experimental physico-chemical characterization and in silico studies were conducted to gain insights into these phenomena. The processability of the hybrids allowed for the preparation of homogeneous films on diverse substrates.
Review
Biochemistry & Molecular Biology
Na-Eun Choi, Ji-Yu Lee, Eun-Chae Park, Ju-Hee Lee, Jiyoun Lee
Summary: This review summarizes the recent reports on organelle-targeted fluorescent probes, evaluating their strategies and structural features based on their target organelles. The article discusses the advantages of the currently used probes, the potential challenges in their application, and future directions for development.
Review
Chemistry, Inorganic & Nuclear
Lei Feng, Jing Ning, Xiangge Tian, Chao Wang, Zhenlong Yu, Xiaokui Huo, Tian Xie, Baojing Zhang, Tony D. James, Xiaochi Ma
Summary: Cytochrome P450 (CYP) enzymes are haem-containing proteins mainly involved in the oxidative metabolism of various chemicals. Fluorescent probes are useful molecular tools for selectively detecting CYP activity, facilitating important insights into the activity expression of CYP enzymes.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Catalina-Paula Spatarelu, Austin Van Namen, Sidhartha Jandhyala, Geoffrey P. Luke
Summary: This study presents a new phase-changing perfluorocarbon nanodroplet contrast agent that improves sensitivity of fluorescence imaging by externally modulating the signal. The nanodroplets undergo liquid-to-gas phase transition when exposed to an externally applied laser pulse, increasing the fluorescent signal. It also demonstrates the production of ultrasound contrast for multimodal imaging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Yu Zhou, Silvia P. Centeno, Kuan Zhang, Lifei Zheng, Robert Goestl, Andreas Herrmann
Summary: This study reports the development of a series of ratiometric optical force probes (OFPs) based on fluorescent-protein-dye and protein-protein conjugates, and their incorporation into genetically engineered bio-glues. The OFPs efficiently modulate Forster resonance energy transfer upon force application, reporting on force-induced molecular alterations independent of concentration and fluorescence intensity. By fluorescence spectroscopy in solution and in the solid state, as well as fluorescence lifetime imaging microscopy, stress concentrations are visualized and adhesive and cohesive failure in the fracture zone is differentiated.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Analytical
Jinrong Wen, Qianying Hua, Sha Ding, Aokui Sun, Yong Xia
Summary: Zinc is a crucial metal element with wide applications in various fields, and its deficiency can lead to multiple diseases. Selective recognition and effective detection of free zinc ions are highly important. Fluorescent probes, with their high sensitivity, selectivity, real-time monitoring capability, and ease of operation, have been widely used for metal ion detection, including convenient and low-cost methods for Zn2+ detection. This article reviews the latest research advances in fluorescent chemosensors for Zn2+ detection from 2019 to 2023, discussing various mechanisms such as PET, ESIPT, ICT, FRET, CHEF, and AIE. The use of these mechanisms in detecting zinc ions is explored through specific cases, some of which have been validated through theoretical calculations.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xinzhu Wang, Shasha He, Penghui Cheng, Kanyi Pu
Summary: A dual-locked and tandem activatable probe (DTAP) is developed for real-time NIRF imaging of intratumoral pyroptosis during cancer chemo-immunotherapy in living mice. The activated signal of DTAP correlates well with tumor-infiltrating cytotoxic T lymphocytes and tumor growth inhibition, enabling the prediction of cancer therapeutic efficacy. This study provides a non-invasive technique to study the regulatory mechanism of pyroptosis in cancer therapy and optimize cancer chemo-immunotherapies.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Manon Guille-Collignon, Jerome Delacotte, Frederic Lemaitre, Eric Labbe, Olivier Buriez
Summary: Recent works focusing on the modulation of organic fluorescent or fluorogenic molecules by electrochemistry highlight the smart use of known molecules, the design of new ones, and the development of instrumentation providing molecular-level time- and space-resolved information.
Review
Pharmacology & Pharmacy
Elide Zingale, Alessia Romeo, Salvatore Rizzo, Cinzia Cimino, Angela Bonaccorso, Claudia Carbone, Teresa Musumeci, Rosario Pignatello
Summary: This review focuses on the latest advances in ocular routes of drug administration, particularly after topical application. The use of fluorescent nanoparticles for tracking and biodistribution studies is discussed, along with their potential applications in diagnostics and therapeutics.
Article
Chemistry, Applied
Przemyslaw Siarkiewicz, Radoslaw Michalski, Adam Sikora, Renata Smulik-Izydorczyk, Marcin Szala, Aleksandra Grzelakowska, Julia Modrzejewska, Asha Bailey, Jacek E. Nycz, Balaraman Kalyanaraman, Jan Grzegorz Malecki, Jacek Zielonka, Radoslaw Podsiadly
Summary: Recent research focuses on the development of redox probes for in vivo applications, particularly near-infrared fluorescent sensors and tricyanofuran-based fluorophores. The tricyanofuran-based boronate probe forms an adduct with glutathione, decreasing its reactivity towards oxidants, while a modified probe derived from 1-naphthalene boronic acid reacts similarly with peroxynitrite but is not influenced by glutathione, making it suitable for real-time monitoring of peroxynitrite formation.
