Utilization of 2(3H)-Furanone Bearing a Pyrazolyl Side Chain for the Construction of a Variety of Thiazolidinone Derivatives

2(3H)-Furanone 1 was utilized for the construction of thiazolidinone derivatives. Thus, upon treatment the cyano derivatives 5 with thioglycolic acid afforded the thiazolidinone derivatives 6. Reaction of the Schiff base derivative 9 with thioglycolic acid gave the thiazolidinone derivative 10. Decomposition of the azides 11 in dry benzene in the presence of thioglycolic acid gave the thiazolidindione derivative 12. Antimicrobial activities of synthesized compounds were tested. Some of the tested compounds showed promising activities.