Article
Materials Science, Multidisciplinary
Wansu Zhang, Shangyu Chen, Shuai Ye, Pengfei Sun, Quli Fan, Jun Song, Pengju Zeng, Jun-Le Qu, Wai-Yeung Wong
Summary: Phosphorescence probes have shown great potential as hypoxia detectors due to their long luminescence lifetime, large Stokes shift, and oxygen sensitivity. However, the low quantum yields of organic phosphorescence probes in the NIR-II window hinder their development in NIR-II hypoxia imaging. This study presents a new NIR-II phosphorescence probe based on phosphorescence resonance energy transfer (PRET) strategy, which exhibits high quantum yield and brightness in both normoxic and oxygen-free environments. In vivo tumor hypoxia imaging experiments demonstrate the high performance of the probe in terms of brightness and signal-to-background ratio.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Analytical
Mozhgan Samandarsangari, Daria O. Kozina, Victor V. Sokolov, Anastasia D. Komarova, Marina V. Shirmanova, Ilya S. Kritchenkov, Sergey P. Tunik
Summary: In this study, new phosphorescent iridium complexes were synthesized with water-soluble and biocompatible properties. The major photophysical characteristics were determined by two cyclometallating ligands based on 2-pyridine-benzothiophene. The use of various diimine ligands influenced the quantum yield of phosphorescence and the sensitivity to oxygen. The complexes demonstrated low toxicity and good water solubility.
Article
Engineering, Biomedical
Wansu Zhang, Shangyu Chen, Pengfei Sun, Shuai Ye, Quli Fan, Jun Song, Pengju Zeng, Junle Qu, Wai-Yeung Wong
Summary: This study reports a new hypoxia probe PpyPt with NIR-II phosphorescence induced by J-aggregation. By constructing J-aggregates, water-soluble PpyPt nanoparticles (PpyPt NPs(4.76)) with good biological hypoxia sensing potential were successfully designed.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Engineering, Biomedical
Huige Zhou, Fenglan Qin, Chunying Chen
Summary: Hypoxia in solid tumors hinders drug delivery and poses challenges for tumor treatment. Recent research on hypoxia-responsive nanomaterials shows promise in overcoming these obstacles and improving therapeutic efficiency.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Kirsten E. Martin, Alexia G. Cosby, Eszter Boros
Summary: The study demonstrates, for the first time, the feasibility of in vivo luminescence imaging by excitation of Eu(III) and Tb(III) complexes using Cherenkov radiation, opening up new possibilities for their use as optical tools for guiding tumor resection during surgery.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Haohao Liu, Wenpeng Ye, Ying Mu, Huili Ma, Anqi Lv, Songde Han, Huifang Shi, Jinhua Li, Zhongfu An, Guoming Wang, Wei Huang
Summary: Room temperature phosphorescence (RTP) has been extensively researched, but developing highly efficient blue RTP materials with long-lived lifetimes is still a challenge. A feasible strategy of ligand functionalization was proposed using metal-organic framework (MOF) as a model, isolating chromophores with assistance of predefined co-ligands and restricting chromophores' motions through coordination and host-guest interactions, achieving highly efficient blue phosphorescence with long lifetimes.
ADVANCED MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Drashti Shah, Menitte Eroy, John Fakhry, Azophi Moffat, Kevin Fritz, Houston D. Cole, Colin G. Cameron, Sherri A. McFarland, Girgis Obaid
Summary: Mic-ML18J03, a micellar formulation of ML18J03, significantly enhances its luminescence yield and accumulative signals in tumors, providing tumor selectivity and overcoming concentration-dependent quenching. This formulation also reduces spectral shifting of the emission maxima during PDT and increases the production of reactive molecular species, highlighting its potential as a versatile approach for in vivo luminescence imaging.
Article
Chemistry, Inorganic & Nuclear
Jian-Ping Xu, Wen Zou, Shun-Ze Zhan, Ji Zheng, Kun Wu, Guo-Hui Zhang, Jing-Hong Li, Mian Li, Guo-Hong Ning, Dan Li
Summary: Six trigonal prismatic metallocages composed of 24 components exhibit host-guest interactions dominated by C-H···π interactions. These metallocages show rare red emissions under visible light and the presence of ligand QT triggers different red emissions under light excitation.
INORGANIC CHEMISTRY FRONTIERS
(2021)
Review
Medicine, Research & Experimental
Deyana Nasri, Rayyan Manwar, Ajeet Kaushik, Ekrem Emrah Er, Kamran Avanaki
Summary: Hypoxia leads to the expression of signaling molecules that regulate cell division, promote angiogenesis, increase resistance to chemotherapy and radiotherapy, and induce metastasis in the tumor microenvironment. Photoacoustic imaging (PAI) utilizes the unique absorption characteristics of chromophores in tissues to construct high-resolution images. This review discusses the physiological characteristics of tumor hypoxia and the current applications of PAI using both label-free and exogenous contrast agents. It analyzes the efficacy of various methods in determining physiological and proteomic phenomena. The review demonstrates that PAI has the potential to understand tumor growth and metastasis development by measuring regulatory molecule concentrations, oxygen gradients, and vascular distribution.
Article
Chemistry, Multidisciplinary
Justin Shum, Lawrence Cho-Cheung Lee, Michael Wai-Lun Chiang, Yun-Wah Lam, Kenneth Kam-Wing Lo
Summary: This article reports a novel targeting strategy that combines an enzyme-instructed self-assembly (EISA) moiety and a strained cycloalkyne to create bioorthogonal sites in cancer cells. These sites can serve as triggers for activation of transition metal-based probes, specifically new ruthenium(II) complexes with a tetrazine unit, enabling controllable phosphorescence and singlet oxygen generation. The study also demonstrates that the hydrophobic regions provided by the large supramolecular assemblies further enhance the environment-sensitive emission of the complexes, making them highly advantageous for biological imaging. Additionally, the (photo)cytotoxicity of the large supramolecular assemblies containing the complexes was investigated, with results showing that cellular localization (extracellular and intracellular) significantly impacts the efficiency of the photosensitizers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Srividya Swaminathan, Jebiti Haribabu, Naveen Kumar Kalagatur, Maroli Nikhil, Nithya Balakrishnan, Nattamai S. P. Bhuvanesh, Krishna Kadirvelu, Ponmalai Kolandaivel, Ramasamy Karvembu
Summary: The synthesis of fourteen new Ru-II-arene complexes were characterized and found to exhibit high toxicity towards IMR-32 cancer cells, with two complexes showing the highest activity and the ability to induce apoptosis and cell cycle arrest. These complexes also demonstrated good binding affinity with receptors commonly overexpressed in cancer cells.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Ludovic Bretin, Yurii Husiev, Vadde Ramu, Liyan Zhang, Matthijs Hakkennes, Selda Abyar, Andrew C. Johns, Sylvia E. Le Devedec, Tania Betancourt, Alexander Kornienko, Sylvestre Bonnet
Summary: By functionalizing a terpyridine-based ruthenium photocage with an amide group, the excited states and toxicity were fine-tuned, leading to enhanced absorption of red light. In vitro and in vivo experiments demonstrated the potential of this compound for cancer treatment.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Materials Science, Multidisciplinary
Jian-Xin Wang, Indranil Dutta, Jun Yin, Tengyue He, Luis Gutierrez-Arzaluz, Osman M. Bakr, Mohamed Eddaoudi, Kuo-Wei Huang, Omar F. Mohammed
Summary: In this study, a highly efficient and reabsorption-free transparent X-ray imaging scintillator was fabricated by utilizing an efficient triplet-triplet energy transfer strategy between TADF-Br and Ir-OMC. The experiments and calculations showed that efficient energy transfer from TADF-Br to Ir-OMC can be achieved, leading to enhanced triplet-state radioluminescence upon X-ray irradiation. The fabricated scintillator achieved a high X-ray imaging resolution of 19.8 lp mm -1 .
Correction
Chemistry, Multidisciplinary
Lu Shen, Xiao-li Ding, Teng-fei He, Xue-li Hao, Jing-fu Guo, Lu-yi Zou, Ai-min Ren
Summary: This study investigates the phosphorescence properties of Cu(i) complexes with (1-(2-pyridyl)pyrazole/imidazole) ligands, and provides new insights into the effects of N^N ligand isomerization and methyl modification on the phosphorescence properties.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jessica Berrones Reyes, Peter S. Sherin, Amrita Sarkar, Marina K. Kuimova, Ramon Vilar
Summary: This study reports a series of new cyclometallated platinum(II) complexes that act as switch-on probes for G-quadruplex DNA by enhancing their phosphorescence upon binding. More importantly, these complexes show a selective and distinct lengthening of their emission lifetime when bound to G-quadruplexes. The researchers demonstrate that this effect can be used to selectively visualize these structures in cells using Phosphorescence Lifetime Imaging Microscopy (PLIM).
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Medicinal
Hisatsugu Yamada, Yoshinori Hasegawa, Yuki Suzuki, Hirohiko Imai, Tetsuya Matsuda, Yu Kimura, Akio Toshimitsu, Yasuhiro Aoyama, Teruyuki Kondo
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2015)
Article
Chemistry, Organic
Tsutomu Yoshimura, Di Yuanjun, Yu Kimura, Hisatsugu Yamada, Akio Toshimitsu, Teruyuki Kondo
Article
Chemistry, Multidisciplinary
Hisatsugu Yamada, Yoshinori Hasegawa, Hirohiko Imai, Yuki Takayama, Fuminori Sugihara, Tetsuya Matsuda, Hidehito Tochio, Masahiro Shirakawa, Shinsuke Sando, Yu Kimura, Akio Toshimitsu, Yasuhiro Aoyama, Teruyuki Kondo
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2015)
Article
Chemistry, Analytical
Yuka Miyake, Syungo Ishikawa, Yu Kimura, Aoi Son, Hirohiko Imai, Tetsuya Matsuda, Hisatsugu Yamada, Akio Toshimitsu, Teruyuki Kondo
Article
Chemistry, Multidisciplinary
Hisatsugu Yamada, Tetsuro Kameda, Yu Kimura, Hirohiko Imai, Tetsuya Matsuda, Shinsuke Sando, Akio Toshimitsu, Yasuhiro Aoyama, Teruyuki Kondo
Article
Oncology
Yusei Shinohara, Yoshio Endo, Chiaki Abe, Ikkyu Shiba, Masahiro Ishizuka, Tohru Tanaka, Yutaka Yonemura, Shun-Ichiro Ogura, Masahide Tominaga, Hisatsugu Yamada, Yoshihiro Uto
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2017)
Article
Oncology
Tomoko Kaneko, Masahide Tominaga, Risa Kouzaki, Ayaka Hanyu, Kazuki Ueshima, Hisatsugu Yamada, Masaki Suga, Tomohiro Yamashita, Tomoaki Okimoto, Yoshihiro Uto
ANTICANCER RESEARCH
(2018)
Article
Oncology
Toru Tasaka, Emi Kuwada, Yuka Izuchi, Ryohei Nishigawa, Hisatsugu Yamada, Hideki Unuma, Ken Tokunaga, Akio Hayakawa, Akiteru Go, Kikyo Go, Yoshihiro Uto
ANTICANCER RESEARCH
(2018)
Article
Chemistry, Organic
Hisatsugu Yamada, Masayuki Kurata, Kazuhito Tanabe, Takeo Ito, Sei-ichi Nishimoto
ORGANIC & BIOMOLECULAR CHEMISTRY
(2012)
Article
Radiology, Nuclear Medicine & Medical Imaging
T. Hara, M. Tominaga, K. Yajyu, R. Kouzaki, A. Hanyu, H. Yamada, M. Sasaki, S. Azane, Y. Uto
INTERNATIONAL JOURNAL OF RADIATION RESEARCH
(2018)
Article
Chemistry, Multidisciplinary
Teruyuki Kondo, Yu Kimura, Hisatsugu Yamada, Yasuhiro Aoyama
Article
Oncology
Yoshiki Shimamura, Dai Tamatani, Syota Kuniyasu, Yusuke Mizuki, Takuma Suzuki, Hanayo Katsura, Hisatsugu Yamada, Yoshio Endo, Tomohiro Osaki, Masahiro Ishizuka, Tohru Tanaka, Nobuyasu Yamanaka, Tsukasa Kurahashi, Yoshihiro Uto
ANTICANCER RESEARCH
(2016)
Article
Oncology
Ikkyu Shiba, Risa Kouzaki, Hisatsugu Yamada, Yoshio Endo, Takahisa Takin, Hiroshi Sato, Keiko Kitazato, Teruyoshi Kageji, Shinji Nagahiro, Yoshihiro Uto
ANTICANCER RESEARCH
(2017)
Article
Oncology
Yoshihiro Uto, Tomohito Kawai, Toshihide Sasaki, Ken Hamada, Hisatsugu Yamada, Daisuke Kuchiike, Kentaro Kubo, Toshio Inui, Martin Mette, Ken Tokunaga, Akio Hayakawa, Akiteru Go, Tomohiro Oosaki
ANTICANCER RESEARCH
(2015)
