Article
Biophysics
Yanhua Tang, Duoduo Zhang, Ye Lu, Songqin Liu, Juan Zhang, Yuepu Pu, Wei Wei
Summary: This study utilized nanoprobes to detect FEN1 activity in vivo. By controlled-release of a fluorescence marker, sensitive detection of FEN1 activity was achieved and tumor cells could be distinguished from normal cells.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Materials Science, Multidisciplinary
Federico Olivieri, Fabio Scherillo, Rachele Castaldo, Mariacristina Cocca, Antonino Squillace, Gennaro Gentile, Marino Lavorgna
Summary: In this study, high-surface-area amino-functionalized mesoporous silica nanoparticles (MSN-NH2) were synthesized and functionalized with benzoyl chloride (MSN-BC) for the release of benzoic acid (BA) in response to acidic and alkaline conditions. These MSN-BC nanoparticles were embedded in acrylic coatings for corrosion protection of aluminum alloys. The coatings showed long-lasting efficiency and were validated through morphological and electrochemical impedance spectroscopy (EIS) measurements, demonstrating their potential for aluminum alloy protection.
ACS APPLIED POLYMER MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Chun Xu, Chang Lei, Yue Wang, Chengzhong Yu
Summary: Dendritic mesoporous silica nanoparticles have attracted attention due to their wide applications, but the terminology used is ambiguous. This review provides a critical analysis of reported dendritic silica nanoparticles according to their structural classification, updating the understanding of their formation mechanisms and the control of structural parameters. The review also focuses on the applications of dendritic mesoporous nanoparticles in the biomedical field, offering new insights into the structure-property relationship.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Materials Science, Biomaterials
Beatriz Mayol, Victor Dato, Manuel Rodriguez, Elena Lucena, Anabel Villalonga, Paula Diez, Sandra Jimenez-Falcao, Felix Sancenon, Alfredo Sanchez, Diana Vilela, Paloma Martinez-Ruiz, Ramon Martinez-Manez, Reynaldo Villalonga
Summary: A novel enzyme-controlled nanomachine with multiple release mechanisms was constructed using modified mesoporous silica nanoparticles and encapsulated drugs. The release of drugs was achieved through the presence of H2O2, acidic media, and enzymatic reactions, allowing for on-command delivery. The nanomachine demonstrated successful controlled release of drugs in cancer cells.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Nanoscience & Nanotechnology
Federico Olivieri, Rachele Castaldo, Mariacristina Cocca, Gennaro Gentile, Marino Lavorgna
Summary: In this study, engineered stimuli-responsive mesoporous silica nanoparticles were developed as multifunctional carriers for a typical corrosion inhibitor, benzotriazole, in polymer coatings. The results showed the high potential of the proposed system for metal protection in both acidic and alkaline environments, due to the synergistic effect of the mesoporous structure and the capping system designed for controlled release and capture of chloride ions.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Tiancong Zhao, Liang Chen, Minchao Liu, Runfeng Lin, Weiluo Cai, Chin-Te Hung, Shangfeng Wang, Linlin Duan, Fan Zhang, Ahmed Elzatahry, Xiaomin Li, Dongyuan Zhao
Summary: We demonstrate the fabrication of highly uniform Janus double-spherical MSN&mPDA nanoparticles using an emulsion-oriented assembly approach. The dual-mesoporous structure enables selective loading of guests in different compartments and the establishment of single-particle-level biological logic gates.
Article
Food Science & Technology
Yingjun Cui, Xiangyou Wang, Meng Cheng, Yanli Guo, Rongfei Zhang
Summary: Mesoporous silica nanoparticles (MSNPs) with different pore structures were developed to carry and release thymol, enhancing its bioavailability. The loading capacity of thymol-loaded MSNPs reached the highest when the ratio of thymol to MSNPs was 3:1. The encapsulation of thymol improved its stability and the release behavior followed Fickian diffusion process. Thymol-loaded MSNPs showed remarkable antimicrobial efficiency against S. aureus.
Article
Agricultural Engineering
Mercedes Jimenez-Rosado, Victor Perez-Puyana, Antonio Guerrero, Alberto Romero
Summary: This study developed controlled-release systems for micronutrients using soy protein as raw material. The results showed the great potential of these systems, especially when combined with nanotechnology, to incorporate micronutrients into crops and improve the benefits of conventional fertilization.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Materials Science, Multidisciplinary
Xiaoxi Zhao, Yuanting Liu, Lijun Hu, Huajie Feng, Xiufang Wang
Summary: Amphiphilic dual shell mesoporous carbon@silica nanoparticles were synthesized successfully using a semi-confined pyrolysis strategy. The external silica shell provided a protective layer for the nanospace and controlled the formation of various structures, while displaying good dispersion in water.
Review
Chemistry, Multidisciplinary
Ping Huang, Daizheng Lian, Hualin Ma, Nansha Gao, Limin Zhao, Ping Luan, Xiaowei Zeng
Summary: Mesoporous silica nanoparticles, with their simple synthesis, biocompatibility, and high surface area, have been developed as drug carriers for targeted and controlled drug release. By designing gated systems using various materials, these nanoparticles offer a new approach for selective delivery of antitumor drugs. Challenges and future prospects of gated mesoporous silica nanoparticles are discussed for their potential in drug delivery systems.
CHINESE CHEMICAL LETTERS
(2021)
Article
Engineering, Biomedical
Maria Vallet-Regi
Summary: This article reports our contributions to mesoporous silica materials in biomedicine, demonstrating their potential in drug delivery with high loading capacity and stimuli-responsive features. The research findings suggest that mesoporous silica nanoparticles have promising applications in drug delivery.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Inorganic & Nuclear
Selvakumari Ulagesan, Madhappan Santhamoorthy, Thi Phan Vy Phan, Krishnapandi Alagumalai, Kokila Thirupathi, Seong-Cheol Kim, Taek-Jeong Nam, Youn-Hee Choi
Summary: In this study, a mesoporous silica material containing amidoxime ligand groups was successfully synthesized through surface modification. The resulting SBA-15@AMI NPs exhibited a high concentration of amidoxime ligands on the surface, making them suitable for pH-responsive drug delivery applications in cancer therapy.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Jad Mahmoud Halabi, Ejaz Ahmed, Samuel Sofela, Pance Naumov
Summary: Dynamic molecular crystals have shown promising potential as energy-transducing materials for actuators, with the ability to substitute micromotor drivers in mechanical positioning and microgripping tasks. Finite element modeling and performance evaluation are essential tools in predicting and optimizing the mechanical response of these materials for soft microrobotics applications.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Applied
Jianguo Feng, Jinghan Yang, Yaming Shen, Wei Deng, Wang Chen, Yingjian Ma, Zhiyang Chen, Sa Dong
Summary: The mesoporous silica nanoparticles loaded with abamectin successfully prepared by a one-pot method not only protect abamectin and extend its efficacy against pests, but also reduce toxicity to cells.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Chemistry, Applied
Xiaodong Xie, Shuqi Li, Yanling Liu, Zhigang Huang, Jun Yi, Xiaofang Li, Chongkai Gao, Fang Wu, Bohong Guo
Summary: In this study, PLGA was used as a carrier to synthesize florfenicol nanoparticles (FF-PLGA NPs) for improved water solubility and controlled drug release. The FF-PLGA NPs showed high antibacterial activity, sustained drug release, and stability. The addition of hydrophilic materials significantly enhanced drug solubility.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Beatriz Lozano-Torres, Juan F. Blandez, Alba Garcia-Fernandez, Felix Sancenon, Ramon Martinez-Manez
Summary: This study describes a new method for senescent cell detection based on lipofuscin labeling using a biorthogonal reaction. The method involves a two-step reaction that forms a clear fluorescence pattern in senescent cells, providing an alternative tool for senescent cell detection.
Correction
Chemistry, Analytical
Beatriz Lozano-Torres, Alba Garcia-Fernandez, Marcia Dominguez, Felix Sancenon, Juan F. Blandez, Ramon Martinez-Manez
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Beatriz Lozano-Torres, Alba Garcia-Fernandez, Marcia Dominguez, Felix Sancenon, Juan F. Blandez, Ramon Martinez-Manez
Summary: In this study, a beta-galactosidase-activatable near-infrared (NIR) senoprobe called NBGal was developed for the detection of senescent cells using the FDA-approved Nile blue (NB) fluorophore. NBGal exhibited selective tracking of senescent cells in vitro and in vivo, making it a qualitative and minimally invasive probe for direct detection of senescent cells.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Marcia Dominguez, Kathleen Meyer, Felix Sancenon, Juan F. Blandez, Manuel Serrano, Ramon Martinez-Manez
Summary: Kidney damage can be monitored using different biomarkers in blood, urine or serum, and kidney failure leads to the overexpression of the alanine aminopeptidase (APN) enzyme in urine. In this study, a molecular probe (NB-ALA) based on the Nile Blue fluorophore (NB) was designed to detect APN enzyme in urine through simple fluorometric measurements.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Amelia Ultimo, Mar Orzaez, Maria J. Santos-Martinez, Ramon Martinez-Manez, Maria D. Marcos, Felix Sancenon, Eduardo Ruiz-Hernandez
Summary: The abnormal expression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium (RPE) is the main cause of subretinal neovascularisation in wet age-related macular degeneration (AMD). Encapsulating anti-VEGF drugs in large pore mesoporous silica nanoparticles (LP-MSNs) provides a potential solution for the issues in current AMD treatment, by improving drug penetration, retention time, and sustained release. In this study, an innovative LP-MSN-based nanosystem, functionalized with polyethylenimine (PEI) chains, is developed for topical administration of anti-VEGF siRNA molecules to RPE cells, demonstrating successful VEGF silencing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Alejandra Estepa-Fernandez, Alba Garcia-Fernandez, Araceli Lerida-Viso, Angela Morella-Aucejo, Juan Jose Esteve-Moreno, Juan F. Blandez, Maria Alfonso, Vicente Candela-Noguera, Gema Vivo-Llorca, Felix Sancenon-Galarza, Mar Orzaez, Ramon Martinez-Manez
Summary: The engineering of nanoparticle communication has gained attention, but communication between nanoparticles and living systems is still understudied. This study explores a strategy that involves nanoparticle-cell-nanoparticle communication through modifying the environment. The targeted therapy through stigmergy communication effectively inhibits tumor growth and reduces metastases in a mouse model of triple-negative breast cancer with minimal side effects.
Article
Pharmacology & Pharmacy
Alejandra Estepa-Fernandez, Alba Garcia-Fernandez, Araceli Lerida-Viso, Juan F. Blandez, Irene Galiana, Felix Sancenon-Galarza, Mar Orzaez, Ramon Martinez-Manez
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited treatment options. Inducing senescence and removing senescent cells (senolysis) has been explored as a method to limit tumor progression. In this study, a combination treatment using palbociclib and navitoclax was found to delay tumor growth and reduce metastasis in a mouse model of aggressive TNBC.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Engineering, Biomedical
Andy Hernandez-Montoto, M. Nieves Aranda, Isabel Caballos, Alba Lopez-Palacios, Maria Angeles Tormo-Mas, Javier Peman, Mireya Prieto Rodriguez, Carlos Picornell, Elena Aznar, Ramon Martinez-Manez
Summary: Fluorogenic probes based on oligonucleotide capped nanoporous anodic alumina films were developed for specific and sensitive detection of human papilloma virus (HPV) DNA. The probes showed high sensitivity and selectivity in detecting 14 different high-risk (hr) HPV types in clinical samples. The optimized synthesis protocol allowed for the production of sensors with high reproducibility and reliable fluorescence signal reading.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Isabel Caballos, Maria Nieves Aranda, Alba Lopez-Palacios, Luis Pla, Sara Santiago-Felipe, Andy Hernandez-Montoto, Maria Angeles Tormo-Mas, Javier Peman, Maria Dolores Gomez-Ruiz, Eva Calabuig, Beatriz Sanchez-Sendra, Clara Frances-Gomez, Ron Geller, Elena Aznar, Ramon Martinez-Manez
Summary: The COVID-19 pandemic has emphasized the importance of testing and tracking infected individuals to mitigate the virus spread. This study introduces a biosensor that uses oligonucleotide-gated nanomaterials for specific detection of the SARS-CoV-2 spike protein. The biosensor showed high sensitivity and successfully detected low concentrations of the pseudotype virus. It was also tested on nasopharyngeal samples from suspected COVID-19 individuals.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Pharmacology & Pharmacy
Cristina de la Torre, Carmen Coll, Amelia Ultimo, Felix Sancenon, Ramon Martinez-Manez, Eduardo Ruiz-Hernandez
Summary: A novel combination of in situ-forming hydrogels and gated mesoporous materials was developed for designing depots that can locally sustainably release chemotherapeutics. The depot is composed of a hyaluronic-based gel loaded with redox-responsive mesoporous silica nanoparticles capped with polyethylene glycol chains containing a disulfide bond. The nanoparticles are able to deliver the cargo in the presence of the reducing agent glutathione, promoting pore opening and cargo delivery. Release studies and cellular assays demonstrated the successful liberation of the nanoparticles and their internalization into cells, leading to significant reduction in cell viability when loaded with doxorubicin. This research opens up possibilities for the development of new depots combining the tunable properties of hyaluronic gels with a wide range of gated materials for enhanced local controlled release of chemotherapeutics.
Article
Engineering, Biomedical
Alba Garcia-Fernandez, Monica Sancho, Eva Garrido, Viviana Bisbal, Felix Sancenon, Ramon Martinez-Manez, Mar Orzaez
Summary: Acute lung injury (ALI) is a severe pulmonary disorder with high mortality and morbidity rates in intensive care unit patients. The activation of NLPR3 inflammasome during ALI leads to the release of proinflammatory factors and pyroptosis, contributing to lung damage. In this study, it is shown that inhibiting ASC oligomerization through MM01 compound can be a potential therapy for ALI. Additionally, using nanoparticles designed to target the inflamed lungs enhances the efficacy of the treatment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Irene Barguilla, Vicente Candela-Noguera, Patrick Oliver, Balasubramanyam Annangi, Paula Diez, Elena Aznar, Ramon Martinez-Manez, Ricard Marcos, Alba Hernandez, Maria Dolores Marcos
Summary: This study evaluated the genotoxicity and transforming ability of different functionalized mesoporous silica nanoparticles on human lung epithelial cells. The results showed that functionalized mesoporous silica nanoparticles induced some measurable adverse effects associated with tumorigenesis, but the toxicity was lower compared to other nanomaterials and certain drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Vicente Candela-Noguera, Maria Alfonso, Pedro Amoros, Elena Aznar, Maria Dolores Marcos, Ramon Martinez-Manez
Summary: This study comprehensively investigates the factors affecting the formation of MCM-41 type mesoporous silica nanoparticles (MSN). The hydrolysis and condensation rates are found to play a central role in nanoparticle formation, and disregarded parameters such as stirring strength and surfactant addition rate are shown to modulate nucleation and growth. Furthermore, the aging and evolution of MSN are studied through the analysis of silica framework consolidation over time, providing insights into obtaining reproducible, homogeneous, and tailored-made MCM-41 type MSN.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
