期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 19, 期 2, 页码 483-487出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201203337
关键词
alkenes; alkynes; deuterium; palladium; regioselectivity
Heavy stuff: A triethylamine-mediated H-D exchange reaction for the conversion of unlabeled alkynes (1) into [D-1]alkynes ([D-1]-1) in a mixture of D2O/THF has been developed. Furthermore, the efficient preparation of site-and regioselectively deuterated alkenes ([D-n]-2) from 1 or [D-1]-1 with palladium on boron nitride (Pd/BN) as the catalyst and gaseous H-2 or D-2 is discussed. The resulting deuterated products are attractive and powerful tools for the synthesis of labeled compounds that are useful across a range of scientific fields (see scheme).
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