Enhancing the Efficiency of Directed Evolution in Focused Enzyme Libraries by the Adaptive Substituent Reordering Algorithm

Why is chemical synthesis and property optimization easier than expected?

(2011) Katharine W. Moore et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Universal characteristics of chemical synthesis and property optimization

(2011) Katharine W. Moore et al.   Chemical Science

Laboratory Evolution of Stereoselective Enzymes: A Prolific Source of Catalysts for Asymmetric Reactions

(2010) Manfred T. Reetz   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Natural Diversity to Guide Focused Directed Evolution

(2010) Helge Jochens et al.   CHEMBIOCHEM

Rational assignment of key motifs for function guides in silico enzyme identification

(2010) Matthias Höhne et al.   Nature Chemical Biology

Directed Evolution of Enantioselective Enzymes: An Unconventional Approach to Asymmetric Catalysis in Organic Chemistry

(2009) Manfred T. Reetz   JOURNAL OF ORGANIC CHEMISTRY

Directed Evolution of an Enantioselective Epoxide Hydrolase: Uncovering the Source of Enantioselectivity at Each Evolutionary Stage

(2009) Manfred T. Reetz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

HotSpot Wizard: a web server for identification of hot spots in protein engineering

(2009) A. Pavelka et al.   NUCLEIC ACIDS RESEARCH

Protein Design by Directed Evolution

(2008) Christian Jäckel et al.   Annual Review of Biophysics

Improved PCR method for the creation of saturation mutagenesis libraries in directed evolution: application to difficult-to-amplify templates

(2008) Joaquin Sanchis et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Rational Design of Antimicrobial C3a Analogues with Enhanced Effects against Staphylococci Using an Integrated Structure and Function-Based Approach†

(2008) Mukesh Pasupuleti et al.   BIOCHEMISTRY

Descriptor-free molecular discovery in large libraries by adaptive substituent reordering

(2008) Scott R. McAllister et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Addressing the Numbers Problem in Directed Evolution

(2008) Manfred T. Reetz et al.   CHEMBIOCHEM

Greatly reduced amino acid alphabets in directed evolution: making the right choice for saturation mutagenesis at homologous enzyme positions

(2008) Manfred T. Reetz et al.   CHEMICAL COMMUNICATIONS

Advances in laboratory evolution of enzymes

(2008) Shimon Bershtein et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

In silico modelling of directed evolution: Implications for experimental design and stepwise evolution

(2008) David C. Wedge et al.   JOURNAL OF THEORETICAL BIOLOGY

Shedding light on the efficacy of laboratory evolution based on iterative saturation mutagenesis

(2008) Manfred T. Reetz et al.   Molecular BioSystems

Kemp elimination catalysts by computational enzyme design

(2008) Daniela Röthlisberger et al.   NATURE

Analysis of the residue-residue coevolution network and the functionally important residues in proteins

(2008) Byung-Chul Lee et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Enzyme optimization: moving from blind evolution to statistical exploration of sequence–function space

(2008) Richard J. Fox et al.   TRENDS IN BIOTECHNOLOGY

Computationally Mapping Sequence Space To Understand Evolutionary Protein Engineering

(2007) K.A. Armstrong et al.   BIOTECHNOLOGY PROGRESS