Review
Chemistry, Inorganic & Nuclear
Zoufeng Xu, Zhigang Wang, Zhiqin Deng, Guangyu Zhu
Summary: Platinum-based anticancer drugs have been widely used in clinical practice for over 40 years, with a focus on developing platinum(IV) prodrugs based on traditional platinum(II) anticancer drugs. Recent progress in the field includes synthesizing platinum(IV) prodrugs with new oxidizing reagents, understanding the hydrolysis and stability of platinum(IV) complexes, and exploring reduction processes to achieve controllable intracellular reduction of platinum(IV) prodrugs. This review aims to enhance researchers' understanding of platinum(IV) anticancer prodrugs and inspire new strategies, ideas, and applications in metal-based drugs.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Daniil Spector, Olga Krasnovskaya, Kirill Pavlov, Alexander Erofeev, Peter Gorelkin, Elena Beloglazkina, Alexander Majouga
Summary: This review summarizes the research on the development of Pt(IV) prodrugs with NSAIDs as axial ligands, their cytotoxic action and anti-inflammatory activity mechanism studies, structure-activity ratio, and therapeutic efficacy. The chemo-anti-inflammatory strategy aims to efficiently deliver cytotoxic metabolites and NSAIDs intracellularly in tumor cells to reduce side effects and increase therapeutic efficacy. Studies have shown high therapeutic efficacy both in vitro and in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Marie-Christin Barth, Norman Haefner, Ingo B. B. Runnebaum, Wolfgang Weigand
Summary: The research explores the anticancer potential of platinum(IV) complexes and investigates the effects of non-steroidal anti-inflammatory drug (NSAID) ligands on their cytotoxicity. The synthesis and characterization of nine platinum(IV) complexes are presented, and their cytotoxic activity is evaluated against ovarian carcinoma cell lines. The most promising complex, Compound 7, induces cell cycle arrest and apoptosis or necrosis in a cell line-dependent manner, acting through a stress response pathway involving p21, CHOP, and ATF3 genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Jun Xiang Ong, Hai Van Le, Violet Eng Yee Lee, Wee Han Ang
Summary: Mitochondria have been identified as important targets for cisplatin in cancer treatment. In addition to cisplatin, anticancer Pt complexes with similar structures have been developed to target mitochondria. The researchers developed a mitochondria-targeted fluorescent probe to monitor Pt accumulation in mitochondria in real time, and identified two distinct pathways through which Pt complexes could be delivered to mitochondria.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Inorganic & Nuclear
Zoufeng Xu, Long Lin, Binbin Fu, Fu-Ping Huang, Qiyuan Zhou, Guangyu Zhu, Zhigang Wang
Summary: The application of new synthetic methods in platinum(iv) anticancer prodrugs increases the availability of accessible entities that can be conjugated to the platinum(iv) center. These new axial ligands not only endow platinum(iv) complexes with unique properties but also inspire new concepts in prodrug design and development.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Inorganic & Nuclear
Bin-Bin Pan, Hui-Zhong Liu, Wei-Han Meng, Xun-Cheng Su
Summary: This study investigated the interaction between a platinum(iv) complex and alpha-synuclein (α-S) using high-resolution NMR spectroscopy and mass spectrometry. The results showed that the Pt(iv) complex was able to oxidize specific methionine residues in α-S under physiological conditions. These findings are important for understanding the oxidative modification of α-S.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Hong Lv, Xinchao Wang, Yanzhao Hao, Chao Ma, Shangda Li, Gang Li, Jian Zhang
Summary: A new method for carboxylation of unactivated sp(2) C-H bonds with CO2 was reported using a rhodium catalyst, generating a series of ferrocene-embedded lactones that are important molecular skeletons in pharmaceuticals and ligands. The first example of asymmetric C-H carboxylation with CO2 was achieved with a chiral NHC ligand, demonstrating moderate enantioselectivity. Preliminary mechanistic experiments revealed bivalent rhodium as the active catalyst, and a reasonable catalytic cycle was proposed.
Article
Biochemistry & Molecular Biology
Man Kshetri, Wjdan Jogadi, Suha Alqarni, Payel Datta, May Cheline, Arpit Sharma, Tyler Betters, Deonya Broyles, Yao-Rong Zheng
Summary: We conducted the first comprehensive investigation on the impact of head group modifications on the anticancer activities of fatty-acid-like Pt(IV) prodrugs (FALPs). We created a small library of FALPs with diverse head group modifications and found that hydrophilic modifications enhanced the potency of these metallodrugs, while hydrophobic modifications decreased their cytotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Daniil Spector, Kirill Pavlov, Elena Beloglazkina, Olga Krasnovskaya
Summary: Pt(IV) prodrugs with a light-controlled mode of activation show high antiproliferative activity when irradiated, but are non-toxic in the absence of light. This review discusses recent advances in photoabsorber-mediated photocontrollable activation of Pt(IV) prodrugs, focusing on the photocatalytic strategy based on flavin derivatives and the conjugation of photoactive molecules with Pt(II) drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Aleen Khoury, Jennette A. Sakoff, Jayne Gilbert, Kieran F. Scott, Shawan Karan, Christopher P. Gordon, Janice R. Aldrich-Wright
Summary: Platinum(IV) prodrugs showed outstanding activity against various cancer cell lines, with nanomolar activities observed. Cellular accumulation of the complexes was correlated with increased cytotoxicity. COX inhibition or lipophilicity did not solely determine the cytotoxicity of these prodrugs.
Article
Polymer Science
Takashi Horiuchi, Soya Makino, Natsuhiro Sano, Hiromitsu Sogawa, Fumio Sanda
Summary: This paper describes the synthesis of Pt-diyne polymers using two different methods and controlling their geometry. The polymers maintained the cyclic structure intact and were stabilized by intramolecular hydrogen bonding and pi-pi interactions.
Article
Biochemistry & Molecular Biology
Meng Wang, Zhikun Liu, Xiaochao Huang, Yuanhang Chen, Yanming Wang, Jing Kong, Yong Yang, Chunhao Yu, Jin Li, Xu Wang, Hengshan Wang
Summary: Novel dual target platinum(IV) complexes showed effective antitumor activities with lower toxicity and resistance factors than standard platinum-based chemotherapeutics, by modulating proapoptosis and prosurvival protein expression levels in cancer cells through mitochondrial dysfunction-induced mechanisms. Compound 11 has the potential to be a lead compound for future cancer therapy due to its potency and selectivity.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Chinky Binnani, Zdenek Leitner, Ivana Cisarova, Petr Stepnicka
Summary: This article describes the synthesis of a new hybrid ligand and its coordination behavior toward light platinum metals. The results suggest that the phosphane moiety prefers to coordinate with soft metal ions, while the amidine moiety can be induced to coordinate through changing the reaction stoichiometry or generating a vacant coordination site at the metal ion.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Michaela Feckova, Samia Kahlal, Thierry Roisnel, Jean-Yves Saillard, Julien Boixel, Mariia Hruzd, Pascal le Poul, Sebastien Gauthier, Francoise Robin-le Guen, Filip Bures, Sylvain Achelle
Summary: A series of five platinum (II) complexes based on 2-phenylpyrimidine ligands were designed in this study. It was found that the presence of substituents on the phenyl ring leads to a red shift of the lowest-energy absorption band and results in emission in the solid state.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Anna Farasat, Francesca Nerli, Luca Labella, Marco Taddei, Simona Samaritani
Summary: A series of dibromo-N-acyclic (NAC) carbene complexes of platinum(II) were synthesized using a previously optimized protocol for analogous chlorinated compounds, starting from trans-[Pt(mu-Br)Br(PPh3)](2). The synthesis involved ring opening of the dinuclear precursor using suitable isonitrile ligands, followed by addition of N,N-diethylamine to the resulting products. Separate investigations were conducted for the two reactions with a focus on the differences between brominated and chlorinated systems.
Review
Electrochemistry
Laura T. Wey, Paolo Bombelli, Xiaolong Chen, Joshua M. Lawrence, Clayton M. Rabideau, Stephen J. L. Rowden, Jenny Z. Zhang, Christopher J. Howe
Article
Immunology
Faizah Alotaibi, Mateusz Rytelewski, Rene Figueredo, Ronak Zareardalan, Meng Zhang, Peter J. Ferguson, Saman Maleki Vareki, Yousef Najajreh, Mikal El-Hajjar, Xiufen Zheng, Wei-ping Min, James Koropatnick
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Review
Chemistry, Multidisciplinary
Jenny Z. Zhang, Erwin Reisner
NATURE REVIEWS CHEMISTRY
(2020)
Correction
Chemistry, Multidisciplinary
Jenny Z. Zhang, Erwin Reisner
NATURE REVIEWS CHEMISTRY
(2020)
Article
Chemistry, Inorganic & Nuclear
Johanna M. Gretarsdottir, Sigridur Jonsdottir, William Lewis, Trevor W. Hambley, Sigridur G. Suman
INORGANIC CHEMISTRY
(2020)
Article
Chemistry, Medicinal
Alexandra Glenister, Catherine K. J. Chen, David J. Paterson, Anna K. Renfrew, Michela Simone, Trevor W. Hambley
Summary: A glucose-based vector conjugated to a tris(methylpyridyl)amine ligand is described for generating targeted chaperone and caging complexes for active anticancer agents. The ligand inhibits hexokinase in cells, showing potential for phosphorylation and targeting cancer cells. The Co(III) complex incorporating this ligand demonstrates glucose-dependent cellular accumulation and potential for targeted delivery of highly toxic anticancer agents.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Physics, Applied
Gideon Segev, Jakob Kibsgaard, Christopher Hahn, Zhichuan J. Xu, Wen-Hui (Sophia) Cheng, Todd G. Deutsch, Chengxiang Xiang, Jenny Z. Zhang, Leif Hammarstrom, Daniel G. Nocera, Adam Z. Weber, Peter Agbo, Takashi Hisatomi, Frank E. Osterloh, Kazunari Domen, Fatwa F. Abdi, Sophia Haussener, Daniel J. Miller, Shane Ardo, Paul C. McIntyre, Thomas Hannappel, Shu Hu, Harry Atwater, John M. Gregoire, Mehmed Z. Ertem, Ian D. Sharp, Kyoung-Shin Choi, Jae Sung Lee, Osamu Ishitani, Joel W. Ager, Rajiv Ramanujam Prabhakar, Alexis T. Bell, Shannon W. Boettcher, Kylie Vincent, Kazuhiro Takanabe, Vincent Artero, Ryan Napier, Beatriz Roldan Cuenya, Marc T. M. Koper, Roel Van de Krol, Frances Houle
Summary: The performance of solar fuel generation devices has made progress, but still faces many scientific and engineering challenges. There is a need to significantly improve conversion efficiency, stability, and product selectivity at the electrode and device level. Additionally, maintaining these performance metrics while scaling up devices and systems and controlling costs and carbon footprint is crucial. This roadmap surveys various aspects of solar fuel generation, highlighting the current state of the art, key challenges, and advancements required to meet them. It can serve as a guide for researchers and funding agencies in addressing the most pressing needs of the field.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2022)
Article
Chemistry, Physical
Xiaolong Chen, Joshua M. Lawrence, Laura T. Wey, Lukas Schertel, Qingshen Jing, Silvia Vignolini, Christopher J. Howe, Sohini Kar-Narayan, Jenny Z. Zhang
Summary: The use of aerosol jet printing with indium tin oxide nanoparticles allows for the generation of hierarchical electrode structures that meet the complex requirements for high biophotoelectrochemical performance. The resulting micropillar array electrodes, when wired to cyanobacteria, exhibit significantly improved biocatalyst loading, light utilization, and electron flux output. This study demonstrates a promising approach to more efficiently harnessing bio-energy from photosynthesis and provides new tools for three-dimensional electrode design.
Article
Multidisciplinary Sciences
Joshua M. Lawrence, Yutong Yin, Paolo Bombelli, Alberto Scarampi, Marko Storch, Laura T. Wey, Alicia Climent-Catala, Geoff S. Baldwin, Danny O'Hare, Christopher J. Howe, Jenny Z. Zhang, Thomas E. Ouldridge, Rodrigo Ledesma-Amaro
Summary: This study developed a strong redox-responsive promoter and derived a mutant promoter library with varying strengths. Using these tools, researchers demonstrated the electrochemical activation of gene expression in electrogenetic systems, providing new means for the design and improvement of electrogenetics.
Article
Multidisciplinary Sciences
Tomi K. Baikie, Laura T. Wey, Joshua M. Lawrence, Hitesh Medipally, Erwin Reisner, Marc M. Nowaczyk, Richard H. Friend, Christopher J. Howe, Christoph Schnedermann, Akshay Rao, Jenny Z. Zhang
Summary: Photosystems II and I (PSII, PSI) are reaction centre-containing complexes driving the light reactions of photosynthesis. In this study, we demonstrated the extraction of electrons directly from photoexcited PSI and PSII at early points with live cyanobacterial cells or isolated photosystems, using exogenous electron mediators. These results challenge previous models and open new avenues for studying and re-wiring photosynthesis.
Article
Chemistry, Inorganic & Nuclear
Anthony T. S. Lo, Jon K. Chen, Vincent Murray, Matthew H. Todd, Trevor W. Hambley
Summary: Complexes incorporating a threading anthraquinone intercalator with pyrrole lexitropsin and platinum(ii) moieties attached were developed to explore novel DNA binding modes, targeting AT-rich regions for high cytotoxicities. The binding of the complexes to DNA showed similar cytotoxic profiles to cisplatin, indicating platinum binding dominated sequence selectivity, while pyrrole lexitropsin slowed intercalation. Evaluation of DNA unwinding profiles post-platinum binding suggested concurrent intercalation and platinum binding.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Eleanor R. Clifford, Robert W. Bradley, Laura T. Wey, Joshua M. Lawrence, Xiaolong Chen, Christopher J. Howe, Jenny Z. Zhang
Summary: The research demonstrates that using low-midpoint potential phenazines can improve energy conversion efficiency in photosynthetic bioelectrochemical systems. Adjusting the concentration of the mediator is necessary to prevent undesirable side reactions and avoid toxicity to biological cells.
Meeting Abstract
Oncology
Faizah Alotaibi, Mateusz Rytelewski, Rene Figueredo, Ronak Zareardalan, Saman Maleki Vareki, Xiufen Zheng, Meng Zhang, Peter Ferguson, Mikal El-Hajjar, Yousef Najajreh, Wei-ping Min, James Koropatnick
Article
Biochemistry & Molecular Biology
Catherine K. J. Chen, Xiao Gui, Peter Kappen, Anna K. Renfrew, Trevor W. Hambley
Article
Chemistry, Inorganic & Nuclear
Catherine K. J. Chen, Peter Kappen, Dan Gibson, Trevor W. Hambley
DALTON TRANSACTIONS
(2020)