期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 18, 期 47, 页码 14904-14917出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201202831
关键词
asymmetric synthesis; carbenes; cyclopropane; fluorine; fluoroalkenes; Michael reaction
The combination of a fluorine atom and a cyclopropane ring, which both possess unique structural and chemical features, can generate new relevant building blocks for the discovery of efficient fluorinated biologically active agents. In this review, we report the different strategies to access monofluorocyclopropanes and highlight some of their attractive biological applications.
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