期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 18, 期 52, 页码 16890-16901出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201202413
关键词
antitumor activity; kinetic resolution; ring contraction; total synthesis; trikentrin
资金
- CNPq
- FAPESP
- CAPES
Several syntheses have already been reported for cis-trikentrins and herbindoles, which are indole alkaloids unsubstituted at the C2 and C3 positions that bear a trans-1,3-dimethylcyclopentyl unit. Herein, we describe the first asymmetric and stereoselective synthesis of the more challenging trans-trikentrin A as its naturally occurring isomer. Different approaches were investigated and the strategy of choice was a combination of an enzymatic kinetic resolution and a thallium(III)-mediated ring contraction. The antiproliferative activities of the natural product and related intermediates have been tested against human tumor cell lines, leading to the discovery of new compounds with potent antitumor activity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据