Article
Chemistry, Multidisciplinary
Andrea Capucciati, Enrico Monzani, Michela Sturini, Stefania Nicolis, Fabio A. Zucca, Luigi Bubacco, Marco Bortolus, Luigi Zecca, Luigi Casella
Summary: The study uses water-soluble melanin-protein-Fe/Cu conjugates derived from norepinephrine and fibrillar beta-lactoglobulin as reliable models for human brain locus coeruleus neuromelanin (NM). Iron and copper promote catecholamine oxidation and tend to remain coupled in oligonuclear aggregates. The Fe-Cu clusters are EPR silent and affect the H-1 NMR spectra of the conjugates.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Alexander Kastner, Hemma Schueffl, Patrick A. Yassemipour, Bernhard K. Keppler, Petra Heffeter, Christian R. Kowol
Summary: Platinum(IV) prodrugs are promising alternatives to platinum(II) anticancer therapeutics. This study investigated the reactivity and synthetic usability of a platinum(IV) complex with hydrolyzable equatorial ligands, and successfully synthesized stable platinum(IV) complexes suitable for long-circulating tumor-targeting strategies. Additionally, platinum(IV) complexes with equatorial maleimides were synthesized, showing prolonged plasma half-life and improved anticancer activity compared to oxaliplatin.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Medicinal
J. Jansi Rani, Sovan Roy
Summary: Cancer is a deadly disease characterized by abnormal cell growth and invasion. Current treatment options lack selectivity and have side effects, driving the search for better anticancer drugs. Copper-containing compounds have shown excellent activity against cancer cells. The redox activity of copper ions, combined with bioactive ligands, contributes to their cytotoxicity. Copper can induce DNA damage and reactive oxygen species production, while light-assisted excitation of copper complexes generates reactive species for photodynamic therapy. In vivo and in vitro studies have demonstrated the effectiveness of copper ions against various cancer cell lines.
Article
Chemistry, Multidisciplinary
Natasha P. Vargo, Jill B. Harland, Bradley W. Musselman, Nicolai Lehnert, Mehmed Z. Ertem, Jerome R. Robinson
Summary: This study reported the reversible interconversion of Cu2O2 cores in copper proteins, as well as the role of CaII in this process. Metal ion binding can stabilize novel reactive fragments and control O-2 activation in biomimetic systems.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Balakrishnan S. Anju, Neeraja R. Nair, Subrata Kundu
Summary: This study demonstrates the importance of the interconversion between nitrite and nitric oxide in maintaining optimal NO flux in mammalian physiology. The research also reveals potential applications of copper-based catalysts in nitrite reduction and deepens our understanding of the involvement of red copper proteins in denitrification.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Inorganic & Nuclear
Joshua Northcote-Smith, Pooja Kaur, Kogularamanan Suntharalingam
Summary: We investigated the anti-cancer stem cell properties of two copper(II) complexes, where complex 1 induces cytotoxic and immunogenic cell death of breast CSCs, and complex 2 is more potent and less toxic towards non-cancerous cells. Complex 2 enters breast CSCs, accumulates in the cytosol, and increases intracellular reactive oxygen species levels to induce cell death.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Anokhi Shah, Michael J. Taylor, Giulia Molinaro, Sellamuthu Anbu, Margaux Verdu, Lucy Jennings, Iuliia Mikulska, Sofia Diaz-Moreno, Hassane EL Mkami, Graham M. Smith, Melanie M. Britton, Janet E. Lovett, Anna F. A. Peacock
Summary: We report the creation of a new copper-binding site within a protein scaffold, which shows promise as an MRI contrast agent despite the general belief that copper is unsuitable for this purpose. The copper coiled coil displays relaxivity values equal to or better than those of the Gd(III) analog, challenging the current consensus. This study demonstrates the power of de novo peptide design in accessing abiological chemistry for practical applications.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Multidisciplinary
Johannes Karges, Mark Kalaj, Milan Gembicky, Seth M. Cohen
Summary: This study proposes a novel approach in drug design, utilizing inorganic metal complexes as inhibitors for the 3CL(pro) cysteine protease of the SARS-CoV-2 virus. Preliminary studies show promising results of selective inhibition and effectiveness.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Stefani Gamboa-Ramirez, Bruno Faure, Marius Reglier, A. Jalila Simaan, Maylis Orio
Summary: The stereoselective copper-mediated hydroxylation of intramolecular C-H bonds from tridentate ligands was reinvestigated using DFT calculations. The computational study provides a rational explanation for the observed regio- and stereoselectivity, as well as insights into the key intermediates and processes involved. These findings are important for a deeper understanding and optimization of such reactions.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Krishna Kumar, Anand K. Agrahari, Rajesh Pratap, Vinod K. Tiwari, Subrato Bhattacharya
Summary: In this study, a series of Cu(I) furan-2-thiocarboxylate complexes were synthesized and characterized. Among them, complex 1 was found to be an excellent catalyst for the synthesis of glycoclusters and glycoconjugate triazoles.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Jennifer Park, Michael B. Cleary, Danyang Li, Joseph A. Mattocks, Jiansong Xu, Huan Wang, Somshuvra Mukhopadhyay, Eric M. Gale, Joseph A. Cotruvo Jr
Summary: The design of selective metal-binding sites is challenging in both small-molecule and macromolecular chemistry. In this study, researchers successfully engineered lanmodulin into genetically encoded fluorescent sensors for selective detection of MnII. These sensors have potential applications in studying photosynthesis, host-pathogen interactions, and neurobiology.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Inorganic & Nuclear
Glenn Blade, Andrew J. Wessel, Karna Terpstra, Liviu M. Mirica
Summary: Two new ligands were synthesized to stabilize copper ions, and their reactions with copper salts resulted in both Cu(II) and Cu(I) complexes. Characterization analysis confirmed the reversible Cu(II)/Cu(I) redox couples of these ligands and complexes. The stability constants, radiolabeling, and cytotoxicity experiments indicated the potential use of these chelators as Cu-64 PET imaging agents in vivo.
Article
Chemistry, Multidisciplinary
Chengzhi Jin, Guanying Li, Xia Wu, Jiangping Liu, Weijun Wu, Yazhou Chen, Toshio Sasaki, Hui Chao, Ye Zhang
Summary: A novel lysosomal probe was designed and synthesized in this study, which self-assembles into stable network structures at extremely low concentrations, enabling long-term live cell imaging. This probe can efficiently label lysosomes in cells up to the 14th passage with minimal impact on luminescence intensity, and illuminated lysosomes are trackable using super-resolution imaging to study their response to cellular processes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Elina Buitrago, Clarisse Faure, Lylia Challali, Elisabetta Bergantino, Ahcene Boumendjel, Luigi Bubacco, Marcello Carotti, Renaud Hardre, Marc Maresca, Christian Philouze, Helene Jamet, Marius Reglier, Catherine Belle
Summary: In this study, a combination of known inhibitors targeting the binuclear copper active site on tyrosinases was investigated, revealing significant enhancement of inhibitory effects, particularly for the HOPNO-TSC compound. The interaction mode with the dicopper(II) active site was elucidated through binding studies with a tyrosinase bio-inspired model, showing that binding to the dicopper center can occur with both chelating sites. Computational and docking studies identified the kojic acid and HOPNO moieties as interacting groups with the dicopper active site.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Physical
Awal Noor, Sadaf Qayyum, Zafar Ali, Niaz Muhammad
Summary: Reacting sterically hindered 1,3-bis(2,6-diethylphenyl)thiourea ligand (L) with various metal salts in acetonitrile yielded bulky thiourea ligand stabilized monomeric complexes. Structural characterization revealed tetrahedral or square planar geometries for different metal complexes. Intermolecular hydrogen bonding and significant intermolecular interactions in the crystal network were observed. Molecular docking analysis showed higher SARS-CoV-2 enzyme interacting abilities of the synthesized complexes compared to the free ligand. The compounds were characterized by elemental analyses, NMR spectroscopy, and single-crystal X-ray diffraction. (c) 2022 Elsevier B.V. All rights reserved.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Inorganic & Nuclear
Edit Mesterhazy, Colette Lebrun, Attila Jancso, Pascale Delangle
INORGANIC CHEMISTRY
(2018)
Article
Chemistry, Inorganic & Nuclear
Edit Mesterhazy, Bastien Boff, Colette Lebrun, Pascale Delangle, Attila Jancso
INORGANICA CHIMICA ACTA
(2018)
Article
Chemistry, Multidisciplinary
Fanny A. Laporte, Colette Lebrun, Claude Vidaud, Pascale Delangleal
CHEMISTRY-A EUROPEAN JOURNAL
(2019)
Article
Chemistry, Physical
Guillaume Coin, Ranjan Patra, Martin Clemancey, Patrick Dubourdeaux, Jacques Pecaut, Colette Lebrun, Ludovic Castro, Pascale Maldivi, Sylvie Chardon-Noblat, Jean-Marc Latour
Article
Chemistry, Inorganic & Nuclear
Jeremy Domergue, Jacques Pecaut, Olivier Proux, Colette Lebrun, Christelle Gateau, Alan Le Goff, Pascale Maldivi, Carole Duboc, Pascale Delangle
INORGANIC CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Laura Gauthier, Mathieu Varache, Anne-Claude Couffin, Colette Lebrun, Pascale Delangle, Christelle Gateau, Isabelle Texier
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Toxicology
Anne Van Der Meeren, David Lemaire, Sylvie Coudert, Guillaume Drouet, Myriam Benameur, Celia Gouzerh, Cien Yoong Hee, Pauline Brunquet, Bastien Trochaud, Magali Floriani, Christelle Gateau, Colette Lebrun, Pascale Delangle, Catherine Berthomieu, Veronique Malard
TOXICOLOGY IN VITRO
(2020)
Article
Chemistry, Physical
Guillaume Coin, Patrick Dubourdeaux, Frederic Avenier, Ranjan Patra, Ludovic Castro, Colette Lebrun, Pierre-Alain Bayle, Jacques Pecaut, Genevieve Blondin, Pascale Maldivi, Jean-Marc Latour
Summary: Multicomponent reactions are of great interest in synthetic chemistry for their efficiency improvement, but understanding their mechanisms is crucial for optimization. Integrated experimental and theoretical approaches are powerful tools to study these mechanisms at the molecular level, providing insights into the complexity of the reactions and guiding the development of more efficient synthetic routes.
Article
Chemistry, Inorganic & Nuclear
Jeremy Domergue, Pawel Guinard, Magali Douillard, Jacques Pecaut, Olivier Proux, Colette Lebrun, Alan Le Goff, Pascale Maldivi, Pascale Delangle, Carole Duboc
Summary: This study reported a bioinspired Ni-II complex demonstrating SOD activity in water and revealed its reaction mechanism with O-2(center dot-) in acetonitrile. The research provides important insights for understanding the mechanism of NiSOD and its potential applications.
INORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ranajit Das, Michael Claron, Colette Lebrun, Jacques Pecaut, Srinivas Ambala, Christelle Gateau, Gouriprasanna Roy, Pascale Delangle
Summary: Imidazole thiones are interesting building blocks for Cu(I) chelation and protection against Cu-mediated oxidative stress. Tripodal molecules derived from nitrilotriacetic acid appended with imidazole thiones show intermediate affinity for Cu(I), with non-alkylated tripods demonstrating significantly higher affinity and efficiency in reducing Cu-mediated oxidative stress than their alkylated counterparts.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Fanny Laporte, Yves Chenavier, Alexandra Botz, Christelle Gateau, Colette Lebrun, Sarah Hostachy, Claude Vidaud, Pascale Delangle
Summary: This study proposes a simple and efficient fluorescence-based method to assess the affinity of proteins and peptides for uranyl, providing a reliable and reproducible assessment for understanding the toxicity of this cation and developing decorporation strategies.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Jerome Laisney, Mireille Chevallet, Caroline Fauquant, Camille Sageot, Yohann Moreau, Daniela Predoi, Nathalie Herlin-Boime, Colette Lebrun, Isabelle Michaud-Soret
Summary: This study investigated the interaction between titanium dioxide nanoparticles (TiO2-NPs) and the chelating enterobactin siderophore, and showed for the first time the dissolution of anatase TiO2-NP surface in the presence of enterobactin, leading to the formation of a hexacoordinated titanium-enterobactin complex.
Article
Chemistry, Inorganic & Nuclear
Guillaume Coin, Patrick Dubourdeaux, Pierre-Alain Bayle, Colette Lebrun, Pascale Maldivi, Jean-Marc Latour
Summary: Multicomponent reactions are of strong interest for the development of more efficient synthetic chemistry. Integrated experimental and theoretical approaches have emerged as the most powerful way to understand their mechanisms, which can be applied to design other multicomponent reactions. The interception of intermediates by acetonitrile in Fe-catalyzed aziridination reveals a new type of multicomponent reaction mechanism.
DALTON TRANSACTIONS
(2021)
Proceedings Paper
Public, Environmental & Occupational Health
Fanny Laporte, Matthieu Stark, Colette Lebrun, Stephane Oros, Nathalie Sisommay, Vicky Gathu, Pier Lorenzo Solari, Gaelle Creff, Jerome Roques, Christophe Den Auwer, Claude Vidaud, Pascale Delangle
12TH INTERNATIONAL CONFERENCE ON THE HEALTH EFFECTS OF INCORPORATED RADIONUCLIDES (HEIR 2018)
(2019)
Article
Chemistry, Multidisciplinary
Valentin Chabert, Vincent Lebrun, Colette Lebrun, Jean-Marc Latour, Olivier Seneque