Article
Biochemistry & Molecular Biology
Karolina Dominiak, Wieslawa Jarmuszkiewicz
Summary: The relationship between mitochondrial production of reactive oxygen species (ROS) and mitochondrial energetics in different rat tissues is dependent on the content of the reduced coenzyme Q pool. Variation in the size of the reduced Q pool in different tissues may reflect diverse levels of ROS production and antioxidant demands. The existence of tissue-specific maximum respiratory chain capacity in ROS production and a proposed new parameter RCRROS highlights the potential control of oxidative phosphorylation through membrane potential.
Article
Biochemistry & Molecular Biology
Karolina Dominiak, Lukasz Galganski, Adrianna Budzinska, Andrzej Woyda-Ploszczyca, Jerzy A. Zoladz, Wieslawa Jarmuszkiewicz
Summary: This study investigated the effects of aerobic exercise on coenzyme Q content and reactive oxygen species formation in the heart, liver and brain of rats. The results showed that aerobic exercise increased mitochondrial biogenesis and the level of reduced coenzyme Q in the heart and brain, acting as an antioxidant. Furthermore, aerobic exercise increased the antioxidant pool in the mitochondria of the heart and liver, but not in the brain. These findings suggest that aerobic exercise plays an important role in energy metabolism, redox homeostasis and oxidative stress levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Chemical
Shuhan Cai, Jingzi Beiyuan, Liyun Huang, Xiaocong Cao, Maojun Deng, Daofei Lv, Xin Chen, Defei Liu, Dongmei Luo, Wenbing Yuan
Summary: In this study, nitrogen-doped graphene quantum dots (N-GQDs) with irregular structure defects and abundant reactive functional groups were successfully prepared using a mechanochemical method. It was found that the N-GQDs can rapidly generate multiple reactive oxygen species (ROS) in the presence of acid without oxygen in dark. The N-GQDs also exhibited efficient catalytic activity in the hydrothermal synthesis of a metal-organic framework.
CHEMICAL ENGINEERING SCIENCE
(2022)
Article
Engineering, Biomedical
Yunxiu Zhang, Qingyan Jia, Fuchun Nan, Jian Wang, Ke Liang, Jian Li, Xiaokuang Xue, Haohui Ren, Weimin Liu, Jiechao Ge, Pengfei Wang
Summary: In this study, three types of red-emissive carbon dots (RCDs) were successfully prepared with maximum emission at approximately 680 nm. The RCDs exhibited adjustable generation of reactive oxygen species (ROS) through type I and type II photodynamic therapy (PDT). The unique ROS formation of RCDs was determined by their core sizes and surface states, and they were able to induce cell programmed death via activating mitochondrion-mediated apoptotic pathways. This work provides a new prospect for RCDs as nanophotosensitizers to overcome the limitations of single type PDT.
Correction
Chemistry, Physical
Shichuan Zhong, Changchang Xing, An Cao, Tao Zhang, Xuejiao Li, Jie Yu, Weiping Cai, Yue Li
Summary: The study discusses a rapid synthesis method for water-soluble MoO3-x quantum dots with controlled oxygen vacancies for detecting H2O2.
NANOSCALE HORIZONS
(2021)
Article
Chemistry, Physical
Zhiling Zhao, Eunkyoung Kim, Dana Motabar, William E. Bentley, Gregory F. Payne
Summary: Redox bioelectronics utilizes electrochemical methods to connect with biology's native redox modality, which involves electron exchange through redox reactions. This study explores electrodes coated with redox-active but non-conducting catechol-containing hydrogels, which are emerging as important materials in redox-based bioelectronics. By increasing the dimensionality of dynamic optical measurements and employing a deterministic network model, the researchers reveal the intrinsic structure of the additional data, enhancing their capabilities for signal detection and interpretation in redox-based bioelectronics.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Bapurao Surnar, Anuj S. Shah, Minseon Park, Akil A. Kalathil, Mohammad Z. Kamran, Royden Ramirez Jaime, Michal Toborek, Madhavan Nair, Nagesh Kolishetti, Shanta Dhar
Summary: HIV infection in the brain leads to viral reservoir formation and affects neural protection. Neuroinflammation caused by drug abuse can exacerbate the infection. Current therapies are unable to cross the blood-brain barrier, limiting their effectiveness in treating neural infection.
Article
Chemistry, Analytical
Nisha Yadav, Deeksha Mudgal, Vivek Mishra
Summary: Carbon quantum dots (CQDs) have emerged as a potential fluorescent probe in bio/analytical chemistry. The optical characteristics of CQDs may be tuned by their functional groups, which can also be used to selectively produce stable bonds with target molecules. High fluorescent ILs-decorated-CQDs (CQDs-IM@OTf) were used as a fluorescence probe for sensitive and precise hemoglobin (Hb) determination, with a minimum detectability of 6.7 nM.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Meng-Jie Fu, Na Wei, Lan-Fang Pang, Xiao-Feng Guo, Hong Wang
Summary: Reactive oxygen species (ROS) are byproducts of aerobic metabolism, playing important roles in physiological processes with concentration-dependent effects. Monitoring ROS reversibly and dynamically is of great significance, but only a few nanosensors have achieved this, with shorter fluorescence wavelengths. In this study, we developed N,Zn co-doped CDs (NZnCDs) with red fluorescence for selective and reversible detection of ONOO-. The NZnCDs respond to ONOO- in a linear manner in the range of 2-40 μM, and can be efficiently recovered by GSH.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Marita A. Cardoso, Abel J. Duarte, Helena M. R. Goncalves
Summary: Three sets of functionalized carbon dots were synthesized and tested as nitric oxide sensors, showing high sensitivity and affinity towards the analyte.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Ting Meng, Zifei Wang, Ting Yuan, Xiaohong Li, Yunchao Li, Yang Zhang, Louzhen Fan
Summary: This study presents a gram-scale synthesis of red/green/blue solid-state fluorescent carbon quantum rings with high quantum yields, offering a potential alternative to REE-free phosphor-converted white LEDs. These R/G/B-SBF-CQRs-based LEDs emit warm white light with low CCT, high CRI, and high luminous efficiency, comparable to REE-phosphor-based LEDs.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Patryk Szymaszek, Patrycja Sroda, Malgorzata Tyszka-Czochara, Anna Chachaj-Brekiesz, Tomasz Swiergosz, Joanna Ortyl
Summary: Here we report the synthesis of a novel fluorescent probe P182 for quantitative measurement of H2O2. This fluorometric probe displays a fluorescence turn-on response in the presence of H2O2. It offers good performances in terms of sensitivity and response time, and shows non-toxic activity for in vivo studies. This study provides research on molecular fluorescence probe for the detection of H2O2.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Chemistry, Multidisciplinary
Plinio Innocenzi, Luigi Stagi
Summary: Carbon dots are nanomaterials with intense photoluminescence, and the emission is determined by factors like structure, surface, and composition. The broad term encompasses various carbon nanostructures, resulting in multiple properties and a lack of clear structure-property relationship. Photoluminescence has gained attention for potential applications in biotechnology, electronics, and energy, while the antioxidant activity of carbon dots has recently been recognized. The review aims to analyze relevant studies and provide an overview of carbon dots as scavengers or radical emitters.
Article
Biochemistry & Molecular Biology
Anita Ayer, Daniel J. Fazakerley, Cacang Suarna, Ghassan J. Maghzal, Diba Sheipouri, Kevin J. Lee, Michelle C. Bradley, Lucia Fernandez-del-Rio, Sergey Tumanov, Stephanie My Kong, Jelske N. van der Veen, Andrian Yang, Joshua W. K. Ho, Steven G. Clarke, David E. James, Ian W. Dawes, Dennis E. Vance, Catherine F. Clarke, Rene L. Jacobs, Roland Stocker
Summary: PEMT deficiency was identified as a positive regulator of CoQ synthesis, altering mitochondrial concentrations of one-carbon metabolites and decreasing mitochondrial oxidative stress. This newly described regulatory pathway may have implications for the treatment of CoQ deficiencies, mitochondrial dysfunction, and associated diseases.
Review
Chemistry, Multidisciplinary
Hwapyong Kim, Ayeong Choe, Seung Beom Ha, Ghulam Mustafa Narejo, Sung Wook Koo, Ji Su Han, Wookjin Chung, Jae-Yup Kim, Jiwoong Yang, Su-Il In
Summary: This review mainly discusses the application of quantum dot-sensitized semiconductors in photoelectrochemical hydrogen production, focusing on the advancements in improving long-term stability through the use of cocatalysts and passivation layers. The working principle of PEC cells, important configurations, and equations for assessing PEC performance are also reviewed.
Article
Nanoscience & Nanotechnology
Dan Zhao, Xiaoyu Huang, Yanan Tian, Jianhua Zou, Fu Wang, Xiaoyuan Chen
Summary: Ferroptosis is a new type of programmed cell death that plays a crucial role in tumor inhibition. This study introduces a facile fluorescence imaging-incorporated transcriptome strategy to visualize and explore the mechanism of GSH depletion-enhanced ferroptosis. The results demonstrate that TfRA-AuNCs, a multifunctional nanoplatform, can enhance the ferroptosis effect in 4T1 cells and regulate the expression change of ferroptosis-related genes. In vivo results confirm the tumor inhibition effect and long-term biocompatibility after TfRA-AuNC treatment. This study provides new insights into the mechanistic study of nanoagent-induced ferroptosis in tumor treatment.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Zheng Li, Jianhua Zou, Xiaoyuan Chen
Summary: Subcellular targeted cancer therapy has emerged as a potent anticancer treatment, providing great opportunities for clinical application. This review summarizes two targeting strategies for four main subcellular organelles, including molecule- and nanomaterial-based targeted delivery or therapeutic strategies. Various treatment strategies such as phototherapy, chemotherapy, radiotherapy, immunotherapy, and combination therapy are discussed in detail. The construction of specific materials based on the properties and mechanisms of organelles allows for the elimination of tumors by inducing dysfunction or destroying specific structures. The challenges faced by organelle-targeting cancer therapies are also summarized. A paradigm for organelle-targeting therapy with enhanced therapeutic efficacy is envisioned.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Vinod Kumar, Heejeong Kim, Bipin Pandey, Tony D. James, Juyoung Yoon, Eric V. Anslyn
Summary: Chemical warfare agents are a major threat to humanity, peace, and social stability. Recent advancements in supramolecular chemistry, analytical chemistry, and molecular sensors have greatly improved our ability to detect and quantify these agents. Fluorescent and colorimetric chemosensors have emerged as attractive tools for selective, sensitive, cheap, portable, and real-time analysis of chemical warfare agents. This review provides a detailed discussion on molecular sensors used for detecting different classes of agents, as well as the current technology and protocols employed by military forces.
CHEMICAL SOCIETY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Wen-Qi Meng, Adam C. Sedgwick, Nahyun Kwon, Mingxue Sun, Kai Xiao, Xiao-Peng He, Eric Anslyn, Tony D. James, Juyoung Yoon
Summary: Chemical warfare agents (CWAs) are targeted toxic chemicals that pose serious threats to public health and global peace. Accurate detection methods for CWAs are essential for security measures. Small molecule fluorescent probes have emerged as attractive tools for CWA detection due to their simplicity, selectivity, and sensitivity, and their ability to be translated into handheld devices.
CHEMICAL SOCIETY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Hai-Hao Han, Han-Min Wang, Paramesh Jangili, Mingle Li, Luling Wu, Yi Zang, Adam C. Sedgwick, Jia Li, Xiao-Peng He, Tony D. James, Jong Seung Kim
Summary: Cancer is a major global health problem, with millions of people diagnosed each year. Current chemotherapy options lack selectivity for cancer cells, are prone to resistance, and have toxicities. Researchers have focused on developing prodrug-based strategies to overcome these limitations. This review discusses recently developed prodrug strategies for cancer therapy and highlights the importance of targeting specific biomarkers in the tumor microenvironment and overexpressed in cancer cells. The advantages and limitations of each approach are also discussed.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Xue-Yuan Wu, Meng-Yin Li, Shao-Jun Yang, Jie Jiang, Yi-Lun Ying, Peng R. Chen, Yi-Tao Long
Summary: Conventional methods for protein nanopore engineering are limited by the 20 natural amino acids, which restricts the diversity of nanopores. To overcome this, we used the genetic code expansion technique to incorporate unnatural amino acids into aerolysin nanopores. Molecular dynamics simulations and single-molecule sensing experiments showed that the newly incorporated amino acids provided a favorable environment for target molecule interactions. This work provides a new framework for creating nanopores with unique sensing properties.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Fantian Zeng, Sureya Nijiati, Longguang Tang, Jinmin Ye, Zijian Zhou, Xiaoyuan Chen
Summary: Understanding the intricate molecular machinery of ferroptosis and leveraging this knowledge can advance disease prevention, diagnosis, treatment, and prognosis. New approaches for in situ detection of key regulators and events provide a comprehensive view of ferroptosis across different scales. Advanced applications integrating ferroptosis detection with cutting-edge technologies show great potential in ferroptosis research. This review summarizes the mechanisms and regulators of ferroptosis, presents detection approaches and applications, and discusses future prospects and challenges for therapeutic development.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Xuanbo Zhang, Bowei Yang, Qianqian Ni, Xiaoyuan Chen
Summary: Cancer vaccines have become an effective tool for cancer immunotherapy, and adjuvants play a crucial role in enhancing immune response. The success of adjuvants in developing stable and immunogenic cancer vaccines has sparked interest in adjuvant development. Advances in materials science offer insights into the rational design of vaccine adjuvants for topical cancer immunotherapy, including molecular adjuvants, polymers/lipids, inorganic nanoparticles, and bio-derived materials. Understanding the physicochemical features of these materials and their engineering strategies can help optimize the effects of adjuvants.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Organic
Mingguang Zhu, Guoyang Zhang, Ziwei Hu, Chaofeng Zhu, Yixiang Chen, Tony D. James, Lijun Ma, Zhuo Wang
Summary: Alzheimer's disease (AD) is a neurodegenerative disease, and detecting amyloid-beta (Aβ) plaques can improve diagnosis and therapy. A new Aβ recognition unit, BocBDP, was developed using the [4-(Boc-amino) benzene] unit. BocBDP can recognize and image Aβ plaques both in vitro and in vivo through hydrogen bonding with amino acid residues Lys16 (K16), Val18 (V18), and Glu22 (E22). BocBDP has a strong binding affinity to Aβ and can cross the blood-brain barrier for at least 2 hours.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Review
Chemistry, Multidisciplinary
Huiyu Niu, Junwei Liu, Helen M. O'Connor, Thorfinnur Gunnlaugsson, Tony D. James, Hua Zhang
Summary: Typical PeT-based fluorescent probes are multi-component systems that utilize a fluorophore connected to a recognition/activating group through an unconjugated linker. These probes have been widely used in cell imaging and disease diagnosis due to their low background fluorescence and significant fluorescence enhancement towards the target. This review summarizes the research progress made in the past five years on PeT-based fluorescent probes targeting cell polarity, pH, and various biological species, emphasizing molecular design strategies, mechanisms, and applications. By providing guidance and promoting the development of new and improved PeT-based fluorescent probes, this review aims to promote the use of PeT-based systems for sensing, imaging, and disease therapy.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Yueci Wu, Lu-Lu Sun, Hai-Hao Han, Xiao-Peng He, Weiguo Cao, Tony D. James
Summary: Drug-induced liver injury (DILI) is a common cause of acute liver failure in the USA and Europe, but most cases can be recovered or prevented by discontinuing the offending drug. Recent research has found that peroxynitrite (ONOO-) can be used as a potential indicator for early diagnosis of DILI, and there is an urgent need to establish a method to detect and track peroxynitrite in DILI cases. In this study, a FRET-based nano fluorescent probe CD-N-I was developed, which showed high selectivity and sensitivity in detecting peroxynitrite. The probe successfully detected exogenous peroxynitrite in live cells and endogenous peroxynitrite in APAP-induced liver injury of HepG2 cells.
Article
Chemistry, Multidisciplinary
Pengfei Zhang, Sheng Yao, Yu Tang, Shanhe Wan, Xiaoyuan Chen, Li Ma
Summary: In this study, a new palliative interventional therapy, nanoparticle-mediated microknife ablation, was developed to eliminate local cancer pain and tumors. Compared to classic chemotherapeutic agents, this therapy showed higher effectiveness in pain removal without damaging the nervous, sensory, and motor capabilities.
Article
Chemistry, Multidisciplinary
Ruixia Liu, Hongda Guo, Mengnan Cao, Ben Dang, Yingxiang Zhai, Shouxin Liu, Shujun Li, Jian Li, Tony D. James, Zhijun Chen
Summary: An efficient top-down method is developed for processing natural wood into RTP films with a lifetime of approximate to 241.9 ms. The treated wood is converted into W-film with good tensile strength, triggering RTP emission and exhibiting energy transfer properties with Rhodamine B. This research is expected to provide a convenient and sustainable method for preparing RTP films.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Si-Min Lu, Kathryn J. Vannoy, Jeffrey E. Dick, Yi-Tao Long
Summary: Studying chemical reactions under nanoconfinement in multiphase environments is of great importance for modern chemists, as it relates to practical problems in fields such as wearable and implantable biosensors, fuel cells, and solar energy conversion. Electrochemistry, as a commonly used multiphase measurement tool, offers insights into these studies. This Perspective focuses on three nanoelectrochemical techniques: stochastic collision electrochemistry, single nanodroplet electrochemistry, and nanopore electrochemistry.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Analytical
Qi-Qi An, Xiao-Zhen Feng, Tao Zhan, Yun-Yun Cheng, Guo-Cheng Han, Zhencheng Chen, Heinz-Bernhard Kraatz
Summary: This study successfully synthesized a PPy-Au nanocomposite and demonstrated its potential for detecting hs-CRP in human serum samples.
