期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 17, 期 30, 页码 8487-8494出版社
WILEY-BLACKWELL
DOI: 10.1002/chem.201003666
关键词
asymmetric synthesis; cross-coupling; natural products; oxepanes; total synthesis
资金
- CSIR, New Delhi
- DST, New Delhi
A stereoselective synthesis of the diterpenoid oxepane (+)-zoapatanol is described. The key steps include a B-alkyl Suzuki cross-coupling reaction for the stereoselective synthesis of trisubstituted alkenes, creation of the two stereogenic centers on the oxepane ring by heterofunctionalization of an alkene through substrate control exploiting the nucleophilic potential of an intramolecular sulfinyl group, and transformation of a beta-hydroxy sulfoxide into a terminal alkene.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据