Review
Gastroenterology & Hepatology
Asako Nogami, Masato Yoneda, Michihiro Iwaki, Takashi Kobayashi, Yasushi Honda, Yuji Ogawa, Kento Imajo, Satoru Saito, Atsushi Nakajima
Summary: Non-alcoholic fatty liver disease is the most common chronic liver disease, with a global prevalence of up to 25%. Simple fatty liver, previously considered benign, is now known to have prognostic significance. Future focus should be on quantifying liver fat. Traditional histological evaluation for fatty liver is invasive, but advancements in technology have made non-invasive imaging methods such as ultrasound, CT, and MRI possible. Quantitative and qualitative measurements for detecting fatty liver are available, and this review summarizes current qualitative evaluations and discusses the future development of quantitative evaluations.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeong Woo Kim, Chang Hee Lee, Baek-Hui Kim, Young-Sun Lee, Soon-Young Hwang, Bit Na Park, Yang Shin Park
Summary: This study aimed to evaluate the feasibility of using ultrasonography (US) for predicting non-alcoholic steatohepatitis (NASH) in patients with non-alcoholic fatty liver disease (NAFLD) and to develop various US indices combining US parameters and laboratory data for the detection of NASH. The results showed that the index combining gray-scale US parameters and AST had the best diagnostic performance for detecting NASH in NAFLD patients, suggesting its potential use as an alternative to liver biopsy.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Medicine, Research & Experimental
Poliana C. Marinello, Paola S. Cella, Mayra T. J. Testa, Phillipe B. Guirro, Walison Augusto da Silva Brito, Camila S. Padilha, Alessandra L. Cecchini, Robin P. da Silva, Jose Alberto R. Duarte, Rafael Deminice
Summary: This study investigated the effects of creatine supplementation on the pathogenesis of non-alcoholic fatty liver disease and alcoholic liver disease. The results showed that creatine supplementation prevented high-fat diet-induced non-alcoholic fatty liver disease but exacerbated ethanol-induced alcoholic liver disease. The exacerbating effects may be related to oxidative stress and inflammation-mediated upregulation of ethanol metabolism.
Article
Nutrition & Dietetics
Azam Doustmohammadian, Elham Pishgar, Cain C. T. Clark, Elham Sobhrakhshankhah, Mehdi Nikkhah, Amir Hossein Faraji, Nima Motamed, Mohsen Reza Mansourian, Bahareh Amirkalali, Mansooreh Maadi, Maryam Sadat Kasaii, Hamidreza Ebrahimi, Farhad Zamani
Summary: This study aimed to investigate the association between dietary patterns and nonalcoholic fatty liver disease (NAFLD). The results showed that a western dietary pattern was associated with an increased risk of NAFLD in Iranian males. Furthermore, a mediation effect of dietary acid load was found in the association between healthy, western, and traditional dietary patterns and NAFLD.
FRONTIERS IN NUTRITION
(2022)
Editorial Material
Gastroenterology & Hepatology
Satya Priya Sharma, Ki Tae Suk, Dong Joon Kim
Summary: The review highlights the crucial role of gut microbes in maintaining liver homeostasis and the impact of dysbiosis on the development of fatty liver disease. The changes in gut microbial composition in alcoholic and nonalcoholic fatty liver diseases and how they contribute to the pathophysiology of the disease are discussed. New approaches related to gut microbes for the diagnosis and treatment of fatty liver disease are also summarized.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Nutrition & Dietetics
Dae Won Ma, Joohun Ha, Kyung Sik Yoon, Insug Kang, Tae Gyu Choi, Sung Soo Kim
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common condition characterized by lipid accumulation in the liver cells with low alcohol consumption. Recent studies have identified the role of damage-associated molecular patterns (DAMPs) and pattern recognition receptors (PRRs) in the development of NAFLD, leading to the activation of immune responses and inflammation. This review provides a comprehensive overview of the impact of DAMPs and PRRs on the pathogenesis of NAFLD.
Article
Gastroenterology & Hepatology
Fuzhen Wan, Feng Pan, Oyekoya T. Ayonrinde, Leon A. Adams, Trevor A. Mori, Lawrence J. Beilin, Therese A. O'Sullivan, John K. Olynyk, Wendy H. Oddy
Summary: This study validated three scoring systems for diagnosing NAFLD in adolescents, with the results indicating that suprailiac skinfold thickness was a better predictor than the scoring systems, particularly performing better in males compared to females.
DIGESTIVE AND LIVER DISEASE
(2021)
Review
Medicine, General & Internal
Guanlin Li, Xinrong Zhang, Huapeng Lin, Lilian Yan Liang, Grace Lai-Hung Wong, Vincent Wai-Sun Wong
Summary: New developments in non-invasive assessment methods show potential in diagnosing and monitoring NAFLD. Magnetic resonance imaging and blood biomarkers can be used to detect hepatic steatosis and fibrosis, but further research is needed to confirm their role in treatment monitoring.
CHINESE MEDICAL JOURNAL
(2022)
Review
Physiology
Dongqing Wu, Huaqing Zhu, Hua Wang
Summary: The liver, as the largest vital solid organ in the body, consists of multiple types of cells that communicate critically to maintain liver function homeostasis. Extracellular vesicles (EVs) play a significant role in cell-to-cell communication and are involved in the development of liver diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Health Care Sciences & Services
Laura Valenzuela-Vallejo, Despina Sanoudou, Christos S. Mantzoros
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease with various complications. The lack of non-invasive diagnosis and effective treatment calls for a more specific subcategorization of fatty liver disease (FLD). A precision medicine approach based on subcategorization is expected to improve patient care and reduce healthcare costs associated with FLD.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Nutrition & Dietetics
Wen Guo, Xinyuan Ge, Jing Lu, Xin Xu, Jiaxin Gao, Quanrongzi Wang, Ci Song, Qun Zhang, Chengxiao Yu
Summary: This large prospective cohort study reveals that an increased intake of food from the Western dietary pattern could be correlated with an increased risk of chronic liver diseases, while the prudent pattern was only correlated with a reduced risk of liver cirrhosis. Higher consumption of red meat and lower consumption of fruit, cereal, tea, and dietary fiber were significantly associated with a higher risk of NAFLD, cirrhosis, and liver cancer.
Article
Nutrition & Dietetics
Ammar Salehi-sahlabadi, Farshad Teymoori, Hamid Ahmadirad, Ebrahim Mokhtari, Mina Azadi, Shaikh Sanjid Seraj, Azita Hekmatdoost
Summary: This case-control study aimed to investigate the possible relationship between nutrient patterns and the risk of non-alcoholic fatty liver disease (NAFLD) among the adult Iranian population. The study identified a nutrient pattern characterized by fructose, vitamin C, vitamin A, pyridoxine, and potassium mainly supplied from fruits, vegetables, and nuts, which was inversely proportional to the odds of NAFLD.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Carlos Jimenez-Cortegana, Alba Garcia-Galey, Malika Tami, Pilar del Pino, Isabel Carmona, Soledad Lopez, Gonzalo Alba, Victor Sanchez-Margalet
Summary: NAFLD affects a quarter of the global population and poses a significant health and economic burden across all countries. The lack of approved pharmacotherapy and well-established diagnostic strategies for this disease highlights the urgency for further research and management efforts. Studies have shown a strong relationship between the hormone leptin and the development of NAFLD, suggesting potential advancements in disease management through further investigation of its role.
Review
Cell Biology
Daryl Ramai, Antonio Facciorusso, Erika Vigandt, Bryan Schaf, Waleed Saadedeen, Aditya Chauhan, Sara di Nunzio, Aashni Shah, Luca Giacomelli, Rodolfo Sacco
Summary: NASH is a chronic and progressive form of non-alcoholic fatty liver disease with increasing global incidence, posing an epidemic and public health threat. The disease is associated with major morbidity and mortality, with patients at risk of developing hepatocellular carcinoma. Current evidence suggests a multi-hit model involving various pathways leading to progressive fibrosis and oncogenesis, highlighting the complexity of the disease.
Review
Gastroenterology & Hepatology
Sakura Yamamura, Dan Nakano, Ryuki Hashida, Tsubasa Tsutsumi, Takumi Kawaguchi, Michiaki Okada, Hiroshi Isoda, Hirokazu Takahashi, Hiroo Matsuse, Yuichiro Eguchi, Yoshio Sumida, Atsushi Nakajima, Lynn Gerber, Zobair M. Younossi, Takuji Torimura
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common liver disease worldwide and it is important to assess all associated outcomes including patient-reported outcomes (PROs). The Chronic Liver Disease Questionnaire (CLDQ)-NAFLD/NASH is a specific instrument developed for this purpose and has shown excellent reliability and validity in international clinical trials.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Surgery
Kazuya Kato, Masahiko Taniguchi, Yoshiaki Iwasaki, Keita Sasahara, Atsushi Nagase, Kazuhiko Onodera, Minoru Matsuda, Yuhei Inaba, Takako Kawakami, Mineko Higuchi, Yuko Kobashi, Hiroyuki Furukawa
AMERICAN JOURNAL OF SURGERY
(2015)
Article
Infectious Diseases
Hideaki Kinugasa, Fusao Ikeda, Kouichi Takaguchi, Chizuru Mori, Takehiro Matsubara, Hidenori Shiraha, Akinobu Takaki, Yoshiaki Iwasaki, Shinichi Toyooka, Kazuhide Yamamoto
Article
Pathology
Shintaro Nanba, Fusao Ikeda, Nobuyuki Baba, Koichi Takaguchi, Tomonori Senoh, Takuya Nagano, Hiroyuki Seki, Yasuto Takeuchi, Yuki Moritou, Tetsuya Yasunaka, Hideki Ohnishi, Yasuhiro Miyake, Akinobu Takaki, Kazuhiro Nouso, Yoshiaki Iwasaki, Kazuhide Yamamoto
JOURNAL OF CLINICAL PATHOLOGY
(2016)
Article
Gastroenterology & Hepatology
Yasushi Yamasaki, Kazuhiro Nouso, Koji Miyahara, Nozomu Wada, Chihiro Dohi, Yuki Morimoto, Hideaki Kinugasa, Yasuto Takeuchi, Tetsuya Yasunaka, Kenji Kuwaki, Hideki Onishi, Fusao Ikeda, Yasuhiro Miyake, Shinichiro Nakamura, Hidenori Shiraha, Akinobu Takaki, Yoshiaki Iwasaki, Maho Amano, Shin-Ichiro Nishimura, Kazuhide Yamamoto
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2015)
Letter
Gastroenterology & Hepatology
Akio Moriya, Yoshiaki Iwasaki, Souhei Ohguchi, Kazuhide Yamamoto
JOURNAL OF HEPATOLOGY
(2015)
Article
Virology
Yoshiaki Iwasaki, Ryo-ichi Okamoto, Yasushi Ishii, Yasuyuki Araki, Noriaki Hashimoto, Kazuhide Yamamoto
JOURNAL OF MEDICAL VIROLOGY
(2015)
Article
Virology
Yoshiaki Iwasaki, Yasuyuki Araki, Hideaki Taniguchi, Ryo-ichi Okamoto, Haruhiko Kobashi, Fusao Ikeda, Yasuhiro Miyake, Akinobu Takaki, Kazuhide Yamamoto
JOURNAL OF MEDICAL VIROLOGY
(2015)
Article
Immunology
Kazuko Koike, Akinobu Takaki, Takahito Yagi, Yoshiaki Iwasaki, Tetsuya Yasunaka, Hiroshi Sadamori, Susumu Shinoura, Yuzo Umeda, Ryuichi Yoshida, Daisuke Sato, Daisuke Nobuoka, Masashi Utsumi, Yasuhiro Miyake, Fusao Ikeda, Hidenori Shiraha, Toshiyoshi Fujiwara, Kazuhide Yamamoto
Article
Surgery
Kazuya Kato, Kazuhiko Onodera, Yoshiaki Iwasaki, Minoru Matsuda, Takako Kawakami, Mineko Higuchi, Kimitaka Kato, Yurina Kato, Masahiko Taniguchi, Hiroyuki Furukawa
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2015)
Article
Medicine, Research & Experimental
Shintarou Nanba, Fusao Ikeda, Shin-ichi Fujioka, Yasuyuki Araki, Kouichi Takaguchi, Noriaki Hashimoto, Hiroyuki Seki, Akinobu Takaki, Yoshiaki Iwasaki, Kazuhide Yamamoto
ACTA MEDICA OKAYAMA
(2015)
Article
Gastroenterology & Hepatology
Yasuto Takeuchi, Fusao Ikeda, Toshiya Osawa, Yasuyuki Araki, Kouichi Takaguchi, Youichi Morimoto, Noriaki Hashimoto, Kousaku Sakaguchi, Tatsuro Sakata, Masaharu Ando, Yasuhiro Makino, Shuji Matsumura, Hiroki Takayama, Hiroyuki Seki, Shintarou Nanba, Yuki Moritou, Tetsuya Yasunaka, Hideki Ohnishi, Akinobu Takaki, Kazuhiro Nouso, Yoshiaki Iwasaki, Kazuhide Yamamoto
WORLD JOURNAL OF HEPATOLOGY
(2015)
Article
Medicine, Research & Experimental
Hiroyuki Seki, Fusao Ikeda, Shintaro Nanba, Yuki Moritou, Yasuto Takeuchi, Tetsuya Yasunaka, Hideki Onishi, Yasuhiro Miyake, Akinobu Takaki, Kazuhiro Nouso, Yoshiaki Iwasaki, Minoru Nakamura, Kazuhide Yamamoto
ACTA MEDICA OKAYAMA
(2015)
Article
Gastroenterology & Hepatology
Hiromitsu Kanzaki, Akinobu Takaki, Takahito Yagi, Fusao Ikeda, Tetsuya Yasunaka, Kazuko Koike, Yasuhiro Miyake, Yoshiaki Iwasaki, Kazuhiro Nouso, Hiroshi Sadamori, Susumu Shinoura, Yuzo Umeda, Ryuichi Yoshida, Masashi Utusmi, Toshiyoshi Fujiwara, Kazuhide Yamamoto
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2014)
Article
Surgery
Kazuya Kato, Yoshiaki Iwasaki, Masahiko Taniguchi, Kazuhiko Onodera, Minoru Matsuda, Takako Kawakami, Mineko Higuchi, Kimitaka Kato, Yurina Kato, Hiroyuki Furukawa
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2015)