Article
Chemistry, Multidisciplinary
Francesco Ferlin, Ioannis Anastasiou, Nihad Salameh, Takeru Miyakoshi, Olivier Baudoin, Luigi Vaccaro
Summary: A heterogeneous catalyst has been prepared for the intramolecular activation/cyclization reaction to synthesize indolines. The catalyst showed high efficiency through a release and catch mechanism, facilitated by iodide ligands. The heterogeneous nature of the catalyst was further utilized in the design of a continuous-flow protocol, enabling efficient recovery and reuse.
Article
Chemistry, Organic
Srishti Ballabh Bahukhandi, Sripati Jana, Rene M. Koenigs
Summary: The study presents a Bronsted-acid catalyzed method for chemoselective C-H functionalization of unprotected N-heterocycles, enabling selective reaction at the C3-position without the need for protecting groups. This approach offers mild reaction conditions, short reaction time, and applicability to both protected indole and unprotected pyrrole heterocycles.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jiaoyu Wu, Linqiang Li, Mengtian Liu, Lu Bai, Xinjun Luan
Summary: A novel Pd-0-catalyzed [2+2+1] annulation was proposed for the rapid assembly of tricyclic indoles in a single-step transformation. Experimental results showed that large tert-butyl and benzyl groups were selectively cleaved via an S(N)1 pathway in the presence of smaller alkyl groups.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Organic
Mikhail Feofanov, Vladimir Akhmetov, Ryo Takayama, Konstantin Amsharov
Summary: A facile synthesis of N-arylated carbazoles via ladderization of fluorinated oligophenylenes is described, involving two subsequent nucleophilic substitutions triggered by an electronic transfer from dimsyl anions. The reaction allows effective one-pot formation of at least six C-N bonds with pronounced selectivity to the C-F bond placement.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Chengtao Yue, Qi Xing, Peng Sun, Zelun Zhao, Hui Lv, Fuwei Li
Summary: The study successfully stabilized palladium in heterogeneous C-C bond formations by developing a novel bifunctional support catalyst, providing new experimental evidence for improving the stability of catalysts and enhancing the efficient applications of supported metal catalysts in advanced synthesis.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Jian Luo, Michael. T. T. Davenport, Chad Callister, Shelley. D. D. Minteer, Daniel. H. H. Ess, T. Leo Liu
Summary: In this study, the mechanism of Ni-catalyzed electrochemical aryl amination reactions was investigated through experiments and calculations. The results revealed that the coordination of an amine to the Ni-II catalyst, followed by the generation of a stable Ni-II aryl amido intermediate and reductive elimination, were key steps in the reaction. The findings provide new insights into the mechanism of this reaction and offer guidance for the development of other Ni-catalyzed electrosynthetic reactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Applied
Ramanna Jatoth, Praveen Kumar Naikawadi, Boyapally Bhaskar, Kishan Gugulothu, Peramalla Edukondalu, K. Shiva Kumar
Summary: Metal-free TFA promoted arylation/heteroarylation was achieved under mild conditions via the reaction of chloro-derivatives of nitrogen heterocycles with electron rich arenes/heteroarenes. It was also observed that TFA was able to facilitate other reactions, resulting in the formation of fused N-heterocycles.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Review
Chemistry, Applied
Jean Le Bras, Jacques Muzart
Summary: This review discusses a variety of Pd-catalyzed reactions using palladium carboxylates in the presence of carboxylic acids and/or alkali metal carboxylates. It highlights the dependence of the efficiency of forming different C-C bonds on the nature of the carboxylate unit. The review presents various procedures, additives, and reaction mechanisms with personal comments.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Review
Chemistry, Applied
Swati Singh, Vishal Jyoti Roy, Neha Dagar, Partha Pratim Sen, Sudipta Raha Roy
Summary: Photoredox catalysis has emerged as an environmentally friendly and cost-effective strategy for promoting challenging C-N bond constructions, and the synergistic action with another catalytic process has a profound impact on the reactivity of traditional synthetic routes. Immense progress has been made in dual-catalysis for achieving various industrially important C-N bond formation processes under milder conditions in recent years.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Physical
Juan Camilo Arango-Daza, Carles Lluna-Galan, Luis Izquierdo-Aranda, Jose R. Cabrero-Antonino, Rosa Adam
Summary: A heterogeneous catalytic system for the acceptorless dehydrogenative condensation between N,N'-disubstituted ureas and 1,2-diols to produce imidazolones was developed. The designed palladium nanoaggregates on an alumina matrix showed good activity and selectivity, with wide applicability and moderate to good yields. Mechanistic studies and characterization were performed, revealing the key factors for the catalyst's activity. Furthermore, a Pd-Zn cooperation effect was described, and bimetallic materials were also designed and characterized properly.
Review
Chemistry, Multidisciplinary
Yan-Nan Zheng, Hongxing Zheng, Ting Li, Wen-Ting Wei
Summary: C-N bonds are widely present in organic materials, natural products, pharmaceutical compounds, and agricultural chemicals. The development of greener and more convenient ways to form C-N bonds, particularly in late-stage synthesis, has become a hot research topic in synthetic chemistry. Copper-catalyzed radical reactions involving N-centered radicals are considered as a sustainable and promising approach for building C-N bonds.
Review
Environmental Sciences
Govardhana Reddy Peddiahgari Vasu, Krishna Reddy Motakatla Venkata, Raghava Reddy Kakarla, Kalluri V. S. Ranganath, Tejraj M. Aminabhavi
Summary: This article explores the research of Pd-PEPPSI complexes in recent years, introducing the synthesis of these catalysts and their applications in various reactions. The article also discusses the reusable heterogeneous PdPEPPSI complexes and their catalytic applications, and concludes with a discussion on chiral Pd complexes and their asymmetric transformations.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Meng-Yue Wang, Xue-Qing Zhu, Bao-Yin Zhao, Hong-Xia Zhang, Yong-Qiang Wang, Qiong Jia
Summary: In this study, the first palladium-catalyzed intramolecular C-H/C-H dehydrogenative coupling reaction of two simple arenes was reported to generate 5,6-dihydrophenanthridines. This approach has a wide substrate scope and good tolerance of functional groups, providing an efficient alternative synthesis route for important 5,6-dihydrophenanthridine compounds.
Article
Chemistry, Multidisciplinary
Nihad Salameh, Federica Valentini, Olivier Baudoin, Luigi Vaccaro
Summary: We report a general and efficient enantioselective C-H arylation of aryl bromides using BozPhos as the bisphosphine ligand and SP-NHC-PdII as recoverable heterogeneous catalyst. By exploiting the release and catch mechanism of action, high enantioselectivities were achieved across different substrates containing methyl, cyclopropyl and aryl C-H bonds. The developed catalytic system provides a more sustainable solution for the synthesis of high added-value chiral products through recycling of the precious metal.
Article
Chemistry, Multidisciplinary
Kunliang Cai, Yuzhao Ran, Wenbo Sun, Sen Gao, Jin Li, Jinqiao Wan, Guansai Liu
Summary: An efficient Pd-promoted hydroamination reaction for the formation of C(sp(3))-N bonds on DNA was reported. This transformation has significant potential for applications in medicinal chemistry and DNA-encoded library synthesis.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Organic
Hongfei Yin, Troels Skrydstrup
JOURNAL OF ORGANIC CHEMISTRY
(2017)
Article
Chemistry, Organic
Anna Skogh, Stig D. Friis, Troels Skrydstrup, Anja Sandstrom
Article
Chemistry, Inorganic & Nuclear
Thomas L. Andersen, Soren Kramer, Jacob Overgaard, Troels Skrydstrup
Article
Chemistry, Organic
Mathias Flinker, Sara Lopez, Dennis U. Nielsen, Kim Daasbjerg, Frank Jensen, Troels Skrydstrup
Article
Chemistry, Multidisciplinary
M. B. Johansen, A. T. Lindhardt
CHEMICAL COMMUNICATIONS
(2018)
Review
Biochemical Research Methods
Dennis U. Nielsen, Karoline T. Neumann, Anders T. Lindhardt, Troels Skrydstrup
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2018)
Article
Chemistry, Applied
Martin B. Johansen, Jens C. Kondrup, Mogens Hinge, Anders T. Lindhardt
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2018)
Article
Chemistry, Organic
Huaifeng Li, Abdullah Al-Dakhil, Daniel Lupp, Sandeep Suryabhan Gholap, Zhiping Lai, Lan-Chang Liang, Kuo-Wei Huang
Article
Chemistry, Applied
Rasmus A. T. Verdier, Jesper H. Mikkelsen, Anders T. Lindhardt
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2018)
Article
Chemistry, Physical
Huaifeng Li, Theo P. Goncalves, Daniel Lupp, Kuo-Wei Huang
Article
Chemistry, Inorganic & Nuclear
Daniel Lupp, Kuo-Wei Huang
Article
Chemistry, Physical
Huaifeng Li, Daniel Lupp, Pradip K. Das, Li Yang, Theo P. Goncalves, Mei-Hui Huang, Marwa El Hajoui, Lan-Chang Liang, Kuo-Wei Huang
Summary: The new imination methodology with a base-metal nickel PN3 pincer catalyst features one-step, waste-free, and high atom-economical characteristics, avoiding the difficulties in purification and waste disposal in traditional methods. Mechanistic insight reveals a non-metal-ligand cooperation pathway, providing an important theoretical basis for modern organic synthesis.
Article
Chemistry, Organic
Martin B. Johansen, Anders T. Lindhardt
ORGANIC & BIOMOLECULAR CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Thomas L. Andersen, Patrik Nordeman, Heidi F. Christoffersen, Helene Audrain, Gunnar Antoni, Troels Skrydstrup
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)
Article
Chemistry, Multidisciplinary
Martin V. Enevoldsen, Jacob Overgaard, Maja S. Pedersen, Anders T. Lindhardt
CHEMISTRY-A EUROPEAN JOURNAL
(2018)
