Article
Radiology, Nuclear Medicine & Medical Imaging
Yongquan Yu, Shuangshuang Xie, Kaiqi Wang, Fuzhi Zhang, Chao Jiang, Caixin Qiu, Jinxia Zhu, Wen Shen
Summary: This study demonstrates that ASL allows quantitative assessment of AKI induced by cholestatic cirrhosis in rats and serves as a noninvasive marker for the early and accurate diagnosis of AKI. The results show that RBF is closely correlated with HE score, HIF-1 alpha score, and PTC density, and can be used to distinguish AKI from non-AKI and mild from severe kidney injury in cirrhosis.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Surgery
Seong Ji Choi, Yoon Jai Hoon, Dong Hee Koh, Hang Lak Lee, Dae Won Jun, Ho Soon Choi
Summary: This study retrospectively analyzed 362 patients who underwent ERCP for CBD stones and found that risk factors such as low cystic duct insertion, distal CBD angulation, larger CBD diameter, more ERCP sessions, and longer cannulation time were associated with symptomatic recurrence of CBD stones. Patients with these risk factors, particularly low cystic duct insertion, should be followed more closely to prevent recurrence.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Guodong Li, Qiuping Pang, Hailan Zhai, Xiujuan Zhang, Yanchun Dong, Ji Li, Xinyong Jia
Summary: The clinical efficacy and safety of SpyGlass-guided laser lithotripsy LCBDE for large CBD stones are comparable to traditional LCBDE, but with less invasiveness. Patients in Group A had shorter hospital stays and enhanced recovery compared to Group B.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Seung Jae Lee, In Seok Choi, Ju Ik Moon, Yong Woo Choi
Summary: Single-stage laparoscopic CBD exploration (LCBDE) combined with laparoscopic cholecystectomy (LC) is a safe and effective treatment option for patients with concomitant gallbladder stones and common bile duct stones compared to endoscopic stone extraction (ESE) combined with LC. LCBDE should be considered for patients at high risk of ESE failure, and careful follow-up is recommended for patients at high risk of recurrence of CBD stones, especially within 24 months after surgical or endoscopic treatment.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Surgery
Jisheng Zhu, Guoyong Li, Peng Du, Xin Zhou, Weidong Xiao, Yong Li
Summary: The study compared the efficacy and safety of LCBDE + LC with IO-ERCP + LC for the treatment of gallbladder and CBD stones, finding no significant difference in technical success, morbidity, major morbidity, and conversion rate. However, LCBDE + LC had a higher biliary leak rate, lower postoperative pancreatitis rate, and higher rate of retained stones compared to IO-ERCP + LC.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Yanjun Wang, Youbao Huang, Chunfeng Shi, Linpei Wang, Shengwei Liu, Jiawei Zhang, Wei Wang
Summary: LCBDE with primary closure is a safe and effective treatment for cholangitis caused by CBDSs, and is not inferior to T-tube drainage in suitable patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Gastroenterology & Hepatology
Sakue Masuda, Kazuya Koizumi, Kento Shionoya, Ryuhei Jinushi, Makomo Makazu, Takashi Nishino, Karen Kimura, Chihiro Sumida, Jun Kubota, Chikamasa Ichita, Akiko Sasaki, Masahiro Kobayashi, Makoto Kako, Uojima Haruki
Summary: Common bile duct stones are a common condition encountered by endoscopists. While there is extensive research in this field, some areas lack sufficient evidence, such as indications for certain procedures and safety considerations. This review comprehensively summarizes standard methods and new findings from recent studies on various aspects of the treatment of common bile duct stones.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Pharmacology & Pharmacy
Hamid Reza Moheimani, Taghi Amiriani, Ali Mohammad Alizadeh, Yahya Jand, Delaram Shakiba, Parham Sayyah Ensan, Fatemeh Jafarzadeh, Maryam Rajaei, Ayesheh Enayati, Mona Pourabouk, Shahriar Aliazadeh, Amir Hoshang Pourkhani, Zohreh Mazaheri, Mohammad Ali Zeyghami, Ahmadreza Dehpour, Vahid Khori
Summary: The study found that ischemic preconditioning can reduce myocardial infarct size, apoptotic indices, arrhythmia, and incidence of ventricular fibrillation in cirrhotic cardiomyopathy rats. Metformin and Cyclosporin-A can exert cardioprotective effects by balancing pAMPK and apoptosis in mitochondria.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Zihang Yuan, Jie Wang, Haoran Zhang, Yingying Miao, Qianhui Tang, Ziqiao Yuan, Cheng Nong, Zhicheng Duan, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu
Summary: In this study, researchers investigated the effects of triptolide (TP), a compound found in Tripterygium wilfordii Hook.f, on cholestasis-induced liver injury. They found that TP reduced liver enzyme levels and necrosis in a mouse model of common bile duct ligation (BDL) cholestasis. TP also inhibited cholangiocyte proliferation and alleviated BDL-induced hepatic fibrosis and inflammation by reducing the expression of RelB.
FRONTIERS IN NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Xu Ji, Zhuo Yang, Shu-Ren Ma, Wen Jia, Qian Zhao, Lu Xu, Ying Kan, Yang Cao, Yao Wang, Bao-Jun Fan
Summary: CBD morphology and diameter >=1.5 cm, as well as ESBD, are independent risk factors for CBD stone recurrence. Patients with S type and polyline type have higher recurrence rates. ESBD can decrease the risk of recurrence.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Medicine, General & Internal
Xiao-Xiao Huang, Jia-Yi Wu, Yan-Nan Bai, Jun-Yi Wu, Jia-Hui Lv, Wei-Zhao Chen, Li-Ming Huang, Rong-Fa Huang, Mao-Lin Yan
Summary: LCBDE is a safe and feasible treatment option for choledocholithiasis patients with small CBD, as it does not increase postoperative bile leak rate compared to patients with large CBD. The study also found no significant difference in the rate of CBDS recurrence between small CBD and large CBD patients. These results provide valuable insights for choosing appropriate treatment methods.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Pediatrics
Jessica L. Rauh, Aravindh S. Ganapathy, Maggie E. Bosley, Alexa Rangecroft, Kristen A. Zeller, Leah M. Sieren, John K. Petty, Thomas Pranikoff, Lucas P. Neff
Summary: This study compared the outcomes of balloon sphincteroplasty with standard transcystic common bile duct exploration and ERCP + LC for pediatric choledocholithiasis. The results showed that balloon sphincteroplasty had a higher success rate, shorter length of stay, and avoided additional invasive procedures.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Review
Surgery
Caining Lei, Tingting Lu, Wenwen Yang, Man Yang, Hongwei Tian, Shaoming Song, Shiyi Gong, Jia Yang, Wenjie Jiang, Kehu Yang, Tiankang Guo
Summary: In comparing LC-IntraERCP and LC-LCBDE, there were no significant differences in terms of surgical success rate, overall postoperative complications, conversion to laparotomy, and operative time. However, LC-IntraERCP may be more effective in reducing the rate of retained stones.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Letter
Gastroenterology & Hepatology
Hirokazu Saito, Shuji Tada
Summary: The newly identified morphological subtypes of CBD may be important risk predictors of stone recurrence after endoscopic stone removal, and they may also predict the risk of residual stones or technical difficulty in stone removal.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Public, Environmental & Occupational Health
Brittany Hjermstad, Dale Snover, Jose D. Debes
Summary: This case report describes a 50-year-old female patient receiving adalimumab therapy who presented with jaundice, fever, and other symptoms. The initial diagnosis was biliary obstruction and potential COVID-19 infection, but further investigation revealed hepatic involvement caused by Histoplasma capsulatum. The patient showed improvement with itraconazole therapy.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Urology & Nephrology
Nadine Kaesler, Felix Schreibing, Thimoteus Speer, Sofia de la Puente-Secades, Nikolas Rapp, Christiane Drechsler, Nazanin Kabgani, Christoph Kuppe, Peter Boor, Vera Jankowski, Leon Schurgers, Rafael Kramann, Juergen Floege
Summary: Chronic kidney disease (CKD) is associated with cardiovascular calcification, partly due to functional vitamin K deficiency. This study investigated the causes of vitamin K deficiency in CKD patients and found disturbances in lipoprotein mediated vitamin K transport and metabolism.
KIDNEY INTERNATIONAL
(2022)
Article
Urology & Nephrology
Josefin Soppert, Janina Frisch, Julia Wirth, Christian Hemmers, Peter Boor, Rafael Kramann, Sonja Vondenhoff, Julia Moellmann, Michael Lehrke, Mathias Hohl, Emiel P. C. van der Vorst, Christian Werner, Thimoteus Speer, Christoph Maack, Nikolaus Marx, Joachim Jankowski, Leticia Prates Roma, Heidi Noels
Summary: Chronic kidney disease (CKD) increases the risk of developing uremic cardiomyopathy, and animal studies are used to investigate the underlying mechanisms. This review systematically analyzed 88 studies and performed meta-analyses of 52 to identify suitable animal models for future experimental studies. The results showed variations in different mouse strains and the effects of CKD on cardiac hypertrophy, fibrosis, and function. Multifactorial hit models consistently induced cardiac hypertrophy and fibrosis compared to single hit kidney injury models.
KIDNEY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Christian Hemmers, Corinna Schulte, Julia Wollenhaupt, Dickson W. L. Wong, Eva Harlacher, Setareh Orth-Alampour, Barbara Mara Klinkhammer, Stephan H. Schirmer, Michael Boehm, Nikolaus Marx, Thimoteus Speer, Peter Boor, Joachim Jankowski, Heidi Noels
Summary: Inflammation and fibrosis are important in the development of chronic kidney disease. This study finds that chemokines CCL6 and CCL9 are upregulated in early CKD, and blocking CCL9 exacerbates kidney inflammation and fibrosis.
Article
Urology & Nephrology
Barbara Mara Klinkhammer, Simone Buchtler, Sonja Djudjaj, Nassim Bouteldja, Runolfur Palsson, Vidar Orn Edvardsson, Margret Thorsteinsdottir, Juergen Floege, Matthias Mack, Peter Boor
Summary: This study analyzed the recovery process of kidney disease and found that tissue injury, fibrosis, and nephron loss during recovery were not reflected by standard measures of kidney function. These findings can contribute to the design of future kidney recovery studies and suggest the need for biomarkers specifically monitoring intra-kidney tissue injury.
KIDNEY INTERNATIONAL
(2022)
Article
Oncology
Jan Bednarsch, Xiuxiang Tan, Zoltan Czigany, Georg Wiltberger, Roman David Buelow, Peter Boor, Sven Arke Lang, Tom Florian Ulmer, Ulf Peter Neumann, Lara Rosaline Heij
Summary: This study investigated the impact of nerve fibers on oncological outcomes in hepatocellular carcinoma patients undergoing surgery, finding that nerve fibers in the tumor microenvironment were not associated with long-term oncological outcomes.
Article
Pathology
Nassim Bouteldja, David Laurin Hoelscher, Barbara Mara Klinkhammer, Roman David Buelow, Johannes Lotz, Nick Weiss, Christoph Daniel, Kerstin Amann, Peter Boor
Summary: This research proposes a novel concept of stain augmentation to develop stain-independent CNNs for digital pathology. It outperforms state-of-the-art techniques and enables segmentation on immunohistochemical stainings without additional annotations, achieving performance comparable to the annotated stain. Examples of application in inflammation and fibrosis quantification are presented, indicating the effectiveness of stain augmentation in deep-learning segmentation algorithms.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Pathology
Katja Ermert, Eva M. Buhl, Barbara M. Klinkhammer, Juergen Floege, Peter Boor
Summary: In chronic kidney disease (CKD), the endothelial glycocalyx (EG) experiences structural and functional changes. The study investigated the ultrastructural alterations of the EG in different CKD models and found reduced binding and significant pathologic alterations in peritubular capillaries.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Urology & Nephrology
Ting Jia, Tong Xu, Bart Smeets, Eva Miriam Buhl, Marcus Johannes Moeller, Juergen Floege, Barbara Mara Klinkhammer, Peter Boor
Summary: The study suggests that PDGF-B and its receptor PDGFR-beta play a crucial role in the development and progression of FSGS by affecting the activation, proliferation, and fibrotic characteristics of PECs. The molecular crosstalk between podocytes and PECs mediated by PDGF-B and PDGFR-beta drives glomerulosclerosis and the progression of FSGS. Treatment with PDGF-B neutralizing antibody can improve kidney function and reduce the occurrence of FSGS.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Letter
Critical Care Medicine
Daniel Gagiannis, Carsten Hackenbroch, Wilhelm Bloch, Fabian Zech, Frank Kirchhoff, Sonja Djudjaj, Saskia von Stillfried, Roman Buelow, Peter Boor, Konrad Steinestel
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Han Wang, Antonia Margarethe Stehr, Jeeshan Singh, Leticija Zlatar, Arndt Hartmann, Katja Evert, Elisabeth Naschberger, Saskia von Stillfried, Peter Boor, Luis E. E. Munoz, Jasmin Knopf, Michael Stuerzl, Martin Herrmann
Summary: During inflammatory responses, neutrophils utilize various defense mechanisms, such as phagocytosis, degranulation, recruitment of immune cells, secretion of anti-microbials, and release of neutrophil extracellular traps (NETs). Detection of NETs in tissue sections can be challenging due to the high fluorescence signals emitted from condensed nuclear DNA. However, using anti-DNA-IgM antibodies can effectively detect the extended DNA patches of NETs, providing a new perspective for studying neutrophil-associated immune reactions in diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marcelo A. S. de Toledo, Xuhuang Fu, Tiago Maie, Eva M. Buhl, Katrin Goetz, Susanne Schmitz, Anne Kaiser, Peter Boor, Till Braunschweig, Nicolas Chatain, Ivan G. Costa, Tim H. Bruemmendorf, Steffen Koschmieder, Martin Zenke
Summary: In this study, human induced pluripotent stem cells were differentiated into mast cells, which exhibited characteristics of systemic mastocytosis disease. These cells can be used for disease modeling and drug screening.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Laura Zarnitz, Benedict M. Doorschodt, Lisa Ernst, Aisa Hosseinnejad, Eileen Edgworth, Tamara Fechter, Alexander Theissen, Sonja Djudjaj, Peter Boor, Rolf Rossaint, Rene H. Tolba, Christian Bleilevens
Summary: Donor organ shortage has led to the use of marginal grafts, but normothermic machine perfusion (NMP) can assess and restore the viability of these grafts before transplantation. An alternative to autologous packed red blood cell (pRBC)-based perfusates is the cell- and oxygen carrier-free solution Ecosol, supplemented with taurine, which may prevent adverse effects. This study compared the effects of 6 h NMP using pRBC and Ecosol on porcine kidneys, and found that despite some tissue damage in the Ecosol group, functional parameters and oxygenation were similar to the pRBC group, and taurine improved antioxidant capacity in the Ecosol group.
Article
Computer Science, Interdisciplinary Applications
Isaac Shiri, Behrooz Razeghi, Alireza Vafaei Sadr, Mehdi Amini, Yazdan Salimi, Sohrab Ferdowsi, Peter Boor, Deniz Guenduez, Slava Voloshynovskiy, Habib Zaidi
Summary: A federated learning (FL) framework was developed for multi-institutional PET/CT image segmentation. The FL algorithms showed comparable performance to centralized learning methods and outperformed the single center-based baseline. The results have promising implications for HN tumor segmentation from PET/CT images.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Mathematical & Computational Biology
Roman D. Buelow, David L. Hoelscher, Ivan G. Costa, Peter Boor
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2023)
Article
Gastroenterology & Hepatology
Mohamed Ramadan Mohamed, Johannes Haybaeck, Hanghang Wu, Huan Su, Matthias Bartneck, Cheng Lin, Mark V. Boekschoten, Peter Boor, Benjamin Goeppert, Christian Rupp, Pavel Strnad, Roger J. Davis, Francisco Javier, Christian Trautwein
Summary: This study investigated the role of JNK1/2 during cholestasis and its hepatocyte-specific function. The results showed that Jnk1 and Jnk2 work together to protect hepatocytes from cholestatic liver disease by controlling Apelin signalling. Blocking Apelin signalling attenuated liver injury and fibrosis induced by cholestasis. Targeting Jnk1/2 in hepatocytes may be a new molecular strategy for treating cholestatic liver disease.