Review
Chemistry, Multidisciplinary
Ping Huang, Daizheng Lian, Hualin Ma, Nansha Gao, Limin Zhao, Ping Luan, Xiaowei Zeng
Summary: Mesoporous silica nanoparticles, with their simple synthesis, biocompatibility, and high surface area, have been developed as drug carriers for targeted and controlled drug release. By designing gated systems using various materials, these nanoparticles offer a new approach for selective delivery of antitumor drugs. Challenges and future prospects of gated mesoporous silica nanoparticles are discussed for their potential in drug delivery systems.
CHINESE CHEMICAL LETTERS
(2021)
Article
Thermodynamics
Dikun Hong, Ting Si, Xin Guo
Summary: This study investigates the dynamic behavior of calcium carboxylate release during Zhundong coal pyrolysis and combustion using ReaxFF MD simulation. The results show that most of the calcium is released into the volatiles during pyrolysis, with thermal cracking of tar fragments significant at high temperatures leading to the conversion of calcium from tar into the organic gas.
PROCEEDINGS OF THE COMBUSTION INSTITUTE
(2021)
Article
Chemistry, Multidisciplinary
Hyunjin Moon, Ryan P. Collanton, Jacob Monroe, Thomas M. Casey, M. Scott Shell, Songi Han, Susannah L. Scott
Summary: In this study, the behavior of water at the interfaces of mesoporous silicas was controlled by modifying their thermal and chemical properties. The results showed that the decrease in surface polarity of inorganic silicas reduced the hydrogen-bonding of water and increased the surface water diffusivity. In contrast, the decrease in polarity of organosilicas decreased the surface water diffusivity, indicating enhanced hydrophobic hydration. These findings validate the control of hydrophobic hydration at interfaces by the microscopic length scale of the hydrophobic regions, and suggest that the hydration thermodynamics of silica surfaces can be tuned to promote adsorption and selectivity in catalytic reactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Applied
Ang Li, Xiao Chen, Tingting Guo, Guangtong Hai, Panpan Liu, Han Yu, Jianhang Xu
Summary: This study utilized molecular dynamics to investigate the molecular motion mechanisms of PCMs with different functional groups confined in mesoporous MCM-41, aiming to reveal the interaction mechanisms between the two at the molecular and atomic levels to provide theoretical guidance for the design and preparation of high-performance composite PCMs based on MCM-41.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Yameng Zhu, Mengmeng Zhang, Shujie Wei, Boyao Wang, Jun He, Xilong Qiu
Summary: In this study, monodisperse and temperature-responsive hollow mesoporous silica nanoparticles (HMSN@P(NIPAM-co-NHMA)) were successfully synthesized, showing excellent drug loading efficiency and temperature-sensitive release behavior. The nanoparticles also exhibited good biocompatibility and stability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biophysics
Yanhua Tang, Duoduo Zhang, Ye Lu, Songqin Liu, Juan Zhang, Yuepu Pu, Wei Wei
Summary: This study utilized nanoprobes to detect FEN1 activity in vivo. By controlled-release of a fluorescence marker, sensitive detection of FEN1 activity was achieved and tumor cells could be distinguished from normal cells.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Materials Science, Biomaterials
Beatriz Mayol, Victor Dato, Manuel Rodriguez, Elena Lucena, Anabel Villalonga, Paula Diez, Sandra Jimenez-Falcao, Felix Sancenon, Alfredo Sanchez, Diana Vilela, Paloma Martinez-Ruiz, Ramon Martinez-Manez, Reynaldo Villalonga
Summary: A novel enzyme-controlled nanomachine with multiple release mechanisms was constructed using modified mesoporous silica nanoparticles and encapsulated drugs. The release of drugs was achieved through the presence of H2O2, acidic media, and enzymatic reactions, allowing for on-command delivery. The nanomachine demonstrated successful controlled release of drugs in cancer cells.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Xiao-Lin Liu, Dong Li, Hai-Xia Zhao, Xin-Wei Dong, La-Sheng Long, Lan-Sun Zheng
Summary: Inorganic-organic hybrid molecular multiferroic and magnetoelectric materials have gained increasing attention due to their diverse structures, flexible frameworks, fascinating physics, and potential applications in multifunctional devices. Recent advances in the field have focused on the magnetoelectricity and relevant mechanisms of these materials, with a personal perspective and outlook provided.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Applied
Jinhua Lei, Zhongzheng Li, Tian He, Zhuqian Wang, Shitao Yao, Huayu Qiu
Summary: This research introduces mesoporous molecular sieves (MMS) into silicone fouling release coatings to achieve controllable release of lubricant and improve the anti-fouling performance of the coatings. The experimental results show that there is a compatibility relationship between the pore size of MMS and the molecular size of the lubricant, and the molecular weight of the lubricant also affects its release.
JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH
(2023)
Article
Materials Science, Ceramics
Nina Velikova, Ivanka Spassova
Summary: Bifunctionalized mesoporous silica materials were successfully prepared by altering the sequence of addition of silanols, leading to improved texture and CO2 sorption capacity. The type of silsesquioxane precursors and the presence of isocyanurate groups also significantly influenced the material's texture, morphology, and CO2 sorption properties.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Erika Nasu, Norifumi Kawakami, Kenji Miyamoto
Summary: Chemical modification of protein nanocages holds promise for various applications, but dual-surface modification using different chemicals remains challenging. Surface pores on artificial protein nanocage TIP60 function as size-dependent molecular filters, allowing only small molecules to pass through. Dual-surface functionalization of TIP60 enables it to release internal small molecules in a redox-responsive manner, making it a useful nanocarrier for drug delivery and molecular filtration systems.
ACS APPLIED NANO MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Xiaoxi Zhao, Yuanting Liu, Lijun Hu, Huajie Feng, Xiufang Wang
Summary: Amphiphilic dual shell mesoporous carbon@silica nanoparticles were synthesized successfully using a semi-confined pyrolysis strategy. The external silica shell provided a protective layer for the nanospace and controlled the formation of various structures, while displaying good dispersion in water.
Article
Materials Science, Multidisciplinary
Federico Olivieri, Fabio Scherillo, Rachele Castaldo, Mariacristina Cocca, Antonino Squillace, Gennaro Gentile, Marino Lavorgna
Summary: In this study, high-surface-area amino-functionalized mesoporous silica nanoparticles (MSN-NH2) were synthesized and functionalized with benzoyl chloride (MSN-BC) for the release of benzoic acid (BA) in response to acidic and alkaline conditions. These MSN-BC nanoparticles were embedded in acrylic coatings for corrosion protection of aluminum alloys. The coatings showed long-lasting efficiency and were validated through morphological and electrochemical impedance spectroscopy (EIS) measurements, demonstrating their potential for aluminum alloy protection.
ACS APPLIED POLYMER MATERIALS
(2023)
Review
Plant Sciences
Dora Lawrencia, See Kiat Wong, Darren Yi Sern Low, Bey Hing Goh, Joo Kheng Goh, Uracha Rungsardthong Ruktanonchai, Apinan Soottitantawat, Learn Han Lee, Siah Ying Tang
Summary: The rising global population is expected to increase the demand for nitrogen fertilizers, with controlled release fertilizers emerging as a potential solution. However, challenges such as tailing effect and high materials cost are hindering the widespread application of CRF in agriculture. This review discusses issues related to conventional fertilizers and CRFs, comparing different raw materials and preparation methods while also examining factors affecting release rate and modeling approaches.
Article
Polymer Science
Xinzhi Cai, Yuqiao Liu, Tiantian Yang, Xuanzuo Dong, Xinru Zhang, Zeyi Jiang, Aihui Chou, Ting Gao, Xinxin Zhang
Summary: Incorporating hybrid fillers into polymer has been proven to be an effective way to obtain composites with high thermal conductivities. By studying the optimal ratios of different types of boron nitride nanosheets, researchers were able to achieve composites with significantly higher thermal conductivities compared to pure PTFE.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Correction
Chemistry, Analytical
Beatriz Lozano-Torres, Alba Garcia-Fernandez, Marcia Dominguez, Felix Sancenon, Juan F. Blandez, Ramon Martinez-Manez
ANALYTICAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Alejandra Estepa-Fernandez, Alba Garcia-Fernandez, Araceli Lerida-Viso, Juan F. Blandez, Irene Galiana, Felix Sancenon-Galarza, Mar Orzaez, Ramon Martinez-Manez
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited treatment options. Inducing senescence and removing senescent cells (senolysis) has been explored as a method to limit tumor progression. In this study, a combination treatment using palbociclib and navitoclax was found to delay tumor growth and reduce metastasis in a mouse model of aggressive TNBC.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Chemistry, Analytical
Eva Garrido, Guillermo Hernandez-Siguenza, Estela Climent, M. Dolores Marcos, Knut Rurack, Pablo Gavina, Margarita Parra, Felix Sancenon, Vicente Marti-Centelles, Ramon Martinez-Manez
Summary: The use of gamma-hydroxybutyric acid (GHB) in drug-facilitated sexual assault has increased, leading to the need for rapid GHB detection methods. A portable strip-based lateral flow assay (LFA) using a smartphone for fluorescence readout was developed for GHB analysis. This method is based on a Cu2+ complex with a tetradentate ligand and the fluorescent dye coumarin 343, and can detect GHB at concentrations as low as 0.03 μM in MES buffer solution and 0.1 μM in soft drinks and alcoholic beverages in just 1 min.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Physical
Migle Ziemyte, Andrea Escudero, Paula Diez, Maria D. Ferrer, Jose R. Murguia, Vicente Marti-Centelles, Alex Mira, Ramon Martinez-Manez
Summary: Development of bioinspired nanomotors with effective propulsion and cargo delivery capabilities has gained significant attention for potential biomedical applications. This study presents the design and application of a multifunctional gated Janus platinum-mesoporous silica nanomotor for disrupting bacterial biofilms. The nanomotor achieves high efficacy in EPS biomass disruption and reduction in cell viability, showcasing its potential as a promising strategy for biofilm elimination.
CHEMISTRY OF MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Goncalo A. Marcelo, David Montpeyo, Joana Galhano, Ramon Martinez-Manez, Jose Luis Capelo-Martinez, Julia Lorenzo, Carlos Lodeiro, Elisabete Oliveira
Summary: In this study, a combinatory antitumoral nanotherapy was developed using magneto-fluorescent nanoparticles as carriers for a combination of two drugs (doxorubicin and ofloxacin) and surface modification with two targeting agents (AZM-SH and Cetuximab). The results showed that the nanoparticles modified with AZM-SH had higher cellular uptake than those modified with Cetuximab, making them more effective for colorectal cancer cells. Furthermore, the oral administration of the nanoparticles with an enteric coating was successfully achieved under extreme conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Cristina Rodriguez-Carrillo, Miriam Benitez, Jamal El Haskouri, Pedro Amoros, Jose V. Ros-Lis
Summary: Covalent organic frameworks (COFs) have attracted great interest as a new type of crystalline porous polymers, but their preparation requires long reaction times. Microwave-assisted synthesis (MAS) offers a promising strategy for accelerating the reaction rate of COFs. In this review, we compile recent studies and experiments on the synthesis of COFs using MAS as an energy source, including imine, triazine, and other 2D COFs. We also summarize the research progress on 3D COFs, providing an overview of the chemical structures, synthesis parameters, and applications of the monomers and COFs in each article.
Article
Engineering, Biomedical
Andy Hernandez-Montoto, M. Nieves Aranda, Isabel Caballos, Alba Lopez-Palacios, Maria Angeles Tormo-Mas, Javier Peman, Mireya Prieto Rodriguez, Carlos Picornell, Elena Aznar, Ramon Martinez-Manez
Summary: Fluorogenic probes based on oligonucleotide capped nanoporous anodic alumina films were developed for specific and sensitive detection of human papilloma virus (HPV) DNA. The probes showed high sensitivity and selectivity in detecting 14 different high-risk (hr) HPV types in clinical samples. The optimized synthesis protocol allowed for the production of sensors with high reproducibility and reliable fluorescence signal reading.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Jose Manuel Terres-Haro, Javier Monreal-Trigo, Andy Hernandez-Montoto, Francisco Javier Ibanez-Civera, Rafael Masot-Peris, Ramon Martinez-Manez
Summary: In this study, a Finite Element Model is used to calculate the absorption and electric field enhancement of metal nanoparticles in an optical, electromagnetic field. The temperature rise caused by irradiating a suspension of nanoparticles was also measured and compared with experimental results.
BIOENGINEERING-BASEL
(2023)
Article
Nanoscience & Nanotechnology
Iris Garrido-Cano, Anna Adam-Artigues, Ana Lameirinhas, Juan F. F. Blandez, Vicente Candela-Noguera, Ana Lluch, Begona Bermejo, Felix Sancenon, Juan Miguel Cejalvo, Ramoin Martinez-Manez, Pilar Eroles
Summary: Despite advances in breast cancer treatment, it remains the leading cause of cancer-related death in women worldwide. In this study, a nanodevice using mesoporous silica nanoparticles for miR-200c-3p delivery was designed and validated. The nanodevice demonstrated biocompatibility, escape ability from endosomes/lysosomes, and inhibition of tumor progression, invasion, migration, and proliferation in vitro. In vivo experiments confirmed tumor targeting, effective miR-200c-3p delivery, therapeutic efficacy with reduced tumor size and lung metastasis, and no signs of toxicity. Overall, miR-200c-3p-loaded nanoparticles present a potential strategy for breast cancer therapy and safe tumor-targeted delivery of microRNAs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Veacheslav Vieru, Silvia Gomez-Coca, Eliseo Ruiz, Liviu F. Chibotaru
Summary: This review discusses the synthesis methods of single-molecule magnets (SMMs) and the basic factors affecting their performance, as well as the strategies for further enhancing SMM performance. Practical approaches for designing SMMs for memory devices are also presented.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Analytical
Oscar Nieves, David Ortiz de Zarate, Elena Aznar, Isabel Caballos, Eva Garrido, Ramon Martinez-Manez, Fabian Dortu, Damien Bernier, Beatriz Mengual-Chulia, F. Xavier Lopez-Labrador, Jens J. Sloth, Katrin Loeschner, Lene Duedahl-Olesen, Natalia Prado, Martin Hervello, Armando Menendez, Rainer Gransee, Thomas Klotzbuecher, M. Clara Goncalves, Fahimeh Zare, Ana Fuentes Lopez, Isabel Fernandez Segovia, Jose M. Barat Baviera, Jaime Salcedo, Sara Recuero, Santiago Simon, Ana Fernandez Blanco, Sergio Peransi, Maribel Gomez-Gomez, Amadeu Griol
Summary: This paper presents a concept for a novel adaptable sensing solution developed under the PHOTONGATE project. The solution allows for quantification of multiple analytes, with high sensitivity and selectivity. It relies on biochemical and photonic technologies and has potential applications in health diagnosis and food safety sectors.
Article
Chemistry, Multidisciplinary
Miriam Benitez, Cristina Rodriguez-Carrillo, Sheila Sanchez-Artero, Jamal El Haskouri, Pedro Amoros, Jose Vicente Ros-Lis
Summary: This study presents an innovative method for the synthesis and functionalization of mesoporous silica material UVM-7. The scaled-up procedures enable rapid synthesis of substantial quantities of materials with reduced environmental impacts.
Article
Chemistry, Applied
Vicente Candela-Noguera, Maria Alfonso, Pedro Amoros, Elena Aznar, Maria Dolores Marcos, Ramon Martinez-Manez
Summary: This study comprehensively investigates the factors affecting the formation of MCM-41 type mesoporous silica nanoparticles (MSN). The hydrolysis and condensation rates are found to play a central role in nanoparticle formation, and disregarded parameters such as stirring strength and surfactant addition rate are shown to modulate nucleation and growth. Furthermore, the aging and evolution of MSN are studied through the analysis of silica framework consolidation over time, providing insights into obtaining reproducible, homogeneous, and tailored-made MCM-41 type MSN.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)