期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 15, 期 3, 页码 710-725出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200800927
关键词
click chemistry; ferrocene; glycoconjugates; molecular sensors; voltammetry
资金
- Spanish Ministry of Education and Science [CTQ2005-02219, CTQ2007-61207]
We report two methods that have allowed the attachment of glucose. mannose and lactose to one or both of the cyclopentadienyl rings of ferrocene. The resulting ferrocene-carbohydrate conjugates were synthesised by the reaction of thioglycosides with ferrocenemethanol and 1,1'-ferrocene-dimethanol in acidic media. A second method based on the regiospecific copper(I)-catalysed cycloaddition of propargyl glycoside, azidomethyl and bis(azidomethyl)ferrocene as well as azidoethyl glycoside and ethynylferrocene was also used and led to the synthesis of 1,2,3-triazole-containing glycoconjugates. The electrochemical behaviour of the synthesised glycoconjugates Was investigated. In addition. their binding interactions with beta-cyclodextrin were Studied by means of NMR spectroscopy, isothermal titration calorimetry and cyclic and differential pulse voltammetric experiments. These techniques allowed the determination of the thermodynamic parameters of the complexes. the stability constants for the complexes formed with both the neutral and the oxidised states of the ferrocenyl glycoconjugates, the mode of inclusion and the diffusion coefficients for both the glycoconjugates and the complexes.
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