BINOL-3,3 '-triflone N,N-dimethyl phosphoramidites: Through-space F-19, P-31 spin-spin coupling with a remarkable dependency on temperature and solvent internal pressure

A combined computational and experimental study of the effects of solvent, temperature and stereochemistry on the magnitude of the through-space spin-spin coupling between P-31 and F-19 nuclei which are six-bonds apart is described. The reaction of 3-trifluoromethylsulfonyl-2,'2-dihydroxy-1,1' F-binaphthalene (3-SO2CF3- BINOL) with hexamethylphosphorous triamide (P(NMe2)(3)) generates a pair of N,N-dimethylphosphoramidites which are diastereomeric due to their differing relative configurations at the stereogenic phosphorous centre and the axially chiral (atropisomeric) BINOL unit. Through-space NMR coupling of the P-31 and F-19 nuclei of the phosphoramidite and sulfone is detected in one diastereomer only. In the analogous N,N-dimethylphosphoramidite generated from 3,3'-(SO2CF3)(2)- BINOL only one of the diastereotopic trifluoromethylsulfone moieties couples with the P-31 of the phosphoramidite. In both cases, the magnitude of the coupling is strongly modulated (up to 400%) by solvent and temperature. A detailed DFT analysis of the response of the coupling to the orientation of the CF3 moiety with respect to the P-lone pair facilitates a confident assignment of the stereochemical identity of the pair of diastereomers. The analysis shows that the intriguing, effects of environment on the magnitude of the coupling can be rationalised by a complex interplay of solvent internal pressure, molecular volume and thermal access to a wider conformational space. These phenomena suggest the possibility for the design of sensitive molecular probes for local environment that can be addressed via through-space NMR coupling.