期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 14, 期 3, 页码 786-793出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200701501
关键词
base flipping; DNA base dynamics; DNA damage; DNA glycosylase
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM056834] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM056834-12, R01 GM056834, R01-GM56834] Funding Source: Medline
The efficient enzymatic detection of damaged bases concealed in the DNA double helix is an essential step during DNA repair in all cells. Emergent structural and mechanistic approaches have provided glimpses into this enigmatic molecular recognition event in several systems. A ubiquitous feature of these essential reactions is the binding of the damaged base in an extrahelical binding mode. The reaction pathway by which this remarkable extrahelical state is achieved is of great interest and even more debate.
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