期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 14, 期 17, 页码 5267-5274出版社
WILEY-BLACKWELL
DOI: 10.1002/chem.200800230
关键词
asymmetric catalysis; basicity; lithium; Michael addition; phosphazene base
Chiral bisphosphazides complexed with lithium salts efficiently catalyze the direct enantioselective 1,4-addition of dialkyl malonates to acyclic enones. Spectroscopic studies on the stoichiometry of the bisphosphazide and lithium salt have indicated the formation of a 1:1 species as the active enantioselective catalyst. It is suggested that the catalyst generates a complex of the protonated phosphazide and the chiral nucleophile as the key intermediate. The phosphazide moiety appears to be a promising dual basic functionality for stereo- and chemoselective catalytic transformations.
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