期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 14, 期 25, 页码 7570-7578出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200800247
关键词
carbohydrates; molecular modeling; molecular recognition; NMR spectroscopy; protein-carbohydrate interactions
资金
- Ministry of Education and Science of Madrid [CIQ2006-10874-C02-01]
- Communaute francaise de Belgique [ARC2002-7]
- Belgian FNRS
- European Commission [MRTN-CT2005-019561]
The interactions of simple carbohydrates with aromatic moieties have been investigated experimentally by NMR spectroscopy. The analysis of the changes in the chemical shifts of the sugar proton signals induced upon addition of aromatic entities has been interpreted in terms of interaction geometries. Phenol and aromatic amino acids (phenylalanine, tyrosine, tryptophan) have been used. The observed sugar-aromatic interactions depend on the chemical nature of the sugar, and thus on the stereochemistries of the different carbon atoms, and also on the solvent. A preliminary study of the solvation state of a model monosaccharide (methyl P-galactopyranoside) in aqueous solution, both alone and in the presence of benzene and phenol, has also been carried out by monitoring of intermolecular homonuclear solvent-sugar and aromatic-sugar NOEs. These experimental results have been compared with those obtained by density functional theory methods and molecular mechanics calculations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据